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Commercial wound dressings for the treatment of exuding wounds:an in-depth physico-chemical comparative study

Burns & Trauma 2022年第1期10卷 465-478页

作者： Manon Minsart Sandra Van Vlierberghe Peter Dubruel Arn Mignon Polymer Chemistry&Biomaterials Research Group Centre of Macromolecular ChemistryDepartment of Organic and Macromolecular ChemistryGhent UniversityKrijgslaan 281Building S4-bis9000 GhentBelgium Smart Polymeric Biomaterials Research Group Biomaterials and Tissue Engineering(SIEM)@Campus Group T LeuvenAndreas Vesaliusstraat 133000 LeuvenBelgium

Background:Nowadays,a wide range of wound dressings is already commercially *** selection of the dressing is of paramount importance as inappropriate wound management and dressing selection can delay the wound healing *** only can this be distressing for the patient,but it can also contribute to complications such as maceration and subsequent *** researchers are targeting the design of dressings with superior properties over existing commercial ***,reported results in the state-of-the-art are rarely benchmarked against commercial *** aim of this study was to determine several characteristics of a large variety of the most frequently used commercial wound dressings,providing an overview for both practitioners and ***:For this comparative study,11 frequently used commercial wound dressings were selected,representing the different *** morphology was studied using scanning electron *** dressings were characterized in terms of swelling capacity(water,phosphate buffered saline and simulated wound fluid),moisture vapour transmission rate(MVTR)and moisture uptake capacity(via dynamic vapour sorption)as well as mechanical properties using tensile testing and ***:The selected dressings showed distinctive morphological differences(fibrous,porous and/or gel)which was reflected in the different ***,the swelling capacities ranged between 1.5 and 23.2 g/g(water),2.1 and 17.6 g/g(phosphate buffered saline)or 2.9 and 20.8 g/g(simulated wound fluid).The swelling capacity of the dressings in water increased even further upon freeze-drying,due to the formation of *** MVTR values varied between 40 and 930 g/m^(2)/24 *** maximal moisture uptake capacity varied between 5.8%and 105.7%at 95%relative *** commercial dressings exhibited a superior mechanical strength,due to either being hydrophobic or ***:The present work not only offers i

关键词： Wound dressings Burns exuding wounds Wound healing Exudate management Physico-chemical

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