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Clinical features and prognosis of multiple myeloma and orbital extramedullary disease:Seven cases report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12365-12374页

作者： Wan-Li Hu Jia-Yin Song Xin Li Xiao-Jiao Pei Jia-Jia Zhang Man Shen Ran Tang Zhen-Yu Pan Zhong-Xia Huang Department of Hematology Multiple Myeloma Medical Center of BeijingBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100043China Department of Radiology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100043China

BACKGROUND Multiple myeloma(MM)complicated with extramedullary disease(EMD)has a poor prognosis and is a limiting factor in the treatment of MM,and no standard treatment is recommended in international *** studies have reported MM with periorbital *** SUMMARY In this paper,the clinical characteristics and survival of seven patients with multiple myeloma and orbital are described and *** common ocular symptoms were blurred vision,proptosis and/or eye movement disorders,IgG type MM may be a risk factor for orbital *** them,six patients were treated with bortezomib-based *** median overall survival(OS)and progression free survival for the entire cohort were 48 and 33 mo,respectively,which was much worse than the OS reported for MM patients without orbital *** Orbital MM may have significantly shortened survival for the entire cohort,so multidisciplinary collaboration is emphasized and recommended in the diagnosis and treatment of these difficult cases.

关键词： Multiple myeloma extramedullary disease Periorbital Treatment Survival Case report

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Novel agents for multiple myeloma with extramedullary disease

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Clinical Cancer Bulletin 2022年第2期1卷 107-115页

作者： Feifei CHEN Aziguli MAIHEMAITI Wenjing WANG Peng LIU Department of Hematology Zhongshan HospitalFudan UniversityShanghaiChina Department of Lymphoma Medicine Affiliated Tumor Hospital of Xinjiang Medical University

Multiple myeloma(MM)is the second most common hematological *** introduction of proteasome inhibitors(PIs)and immunomodulatory drugs(IMiDs)greatly improved the outcomes for these *** disease(EMD),an aggressive manifestation of MM,remains a significant treatment ***,active clinical development of remarkable novel agents for MM with new mechanisms of action has *** agents show promising anti-MM effects and provide the opportunity to extend the survival of *** include next-generation PIs and IMiDs;monoclonal antibodies;chimeric antigen receptor T cells;antibody-drug conjugates;bispecific T cell engager antibodies;and small molecular ***,few clinical trials have focused on patients with EMD,and the effectiveness of these agents has not been well evaluated and compared in these *** this review,we summarize the efficacy of these novel agents in MM patients with EMD.

关键词： multiple myeloma extramedullary disease monoclonal antibody immune therapies

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Myeloid sarcoma of the colon as initial presentation in acute promyelocytic leukemia:A case report and review of the literature

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World Journal of Clinical Cases 2021年第21期9卷 6017-6025页

作者： Lei Wang Da-Li Cai Na Lin Department of Hematology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Myeloid sarcoma(MS)rarely occurs in acute promyelocytic leukemia(APL)at onset,but it can develop in relapse cases,especially after APL treated with alltrans retinoic acid(ATRA).Therefore little is known about the clinical features and suitable treatment for APL related MS due to the rarity of the disease,although this may be different from the treatment and prognosis of MS in the relapse *** our best knowledge,this is the second case report of APL initial presentation as colon *** SUMMARY A 77-year-old woman complained of intermittent right lower abdominal pain,black stool,and difficult defecation for 2 *** examination showed diffuse tenderness during deep palpation and an anemic *** findings showed positivity for fecal occult blood testing;white blood cell count:3.84×109/L;hemoglobin:105 g/L;platelet count:174×109/L;and negativity for tumor *** enhanced computed tomography showed a space occupying lesion in the colon(1.9 cm).Fibrocolonoscopy revealed a polypoid and ulcerated mass measuring 2.5 *** tumor was *** our surprise,MS was confirmed by ***/RARαfusion gene was detected in colon specimens by fluorescent in situ hybridization and real-time reverse transcription polymerase chain reaction,which was consistent with the bone *** was diagnosed as having APL related MS.A smooth and unobstructed intestinal wall was found by fibrocolonoscopy,and continuous molecular remission was confirmed in both the bone marrow and colon after four courses of ATRA+arsenic trioxide(ATO).ATRA+ATO showed a favorable therapeutic response for both APL and *** Early use of ATRA can benefit APL patients,regardless of whether MS is the first or recurrent manifestation.

关键词： Acute promyelocytic leukemia Myeloid sarcoma All-trans retinoic acid extramedullary disease Colon Fluorescent in situ hybridization Case report

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