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Genital and extragenital Canine Transmissible Venereal Tumor in Dogs in Grenada, West Indies

Open Journal of Veterinary Medicine 2013年第2期3卷 111-114页

作者： Alfred Chikweto Sachin Kumthekar Hugh Larkin Claude Deallie Keshaw P. Tiwari Ravindra N. Sharma Muhammad I. Bhaiyat Pathobiology Academic Program School of Veterinary Medicine St. George’s University St. George Grenada

Transmissible venereal tumor (TVT) is a widely reported transplantable tumor in dogs, with no breed or sex predilection and with a low metastatic rate. This retrospective study conducted from 2005 and 2011 sought to evaluate the total number of TVT cases, and to report extragenital TVT lesions in dogs from the small tropical island of Grenada, West Indies. Evaluation of the biopsy and necropsy specimens from dogs with TVT was carried out by cytological and histopathological methods. In the present study, we observed a total of 78 dogs with TVT, comprising 40 male and 38 female dogs. Most cases were from dogs between 3 and 6 years;less frequently from older dogs (over 6 years) or younger dogs (1 - 2 years of age). In the present study, we report 15 cases (19.2%) of dogs with TVT in extragenital sites. Tumors were noted in the nasal cavity, eye orbit, spleen, liver, skin, ribs, subcutaneous, and submandibular, cervical and inguinal lymph nodes. There was also evidence of metastasis to the ovaries in 2 dogs. The most interesting finding was the presence of extragenital lesions without primary genital involvement in 4 cases (5.1%). Our findings emphasize the need to consider TVT on the list of differential diagnosis for masses in extragenital sites in dogs from geographic regions where TVT is prevalent.

关键词： Dog extragenital Transmissible Venereal Tumor Grenada

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Primary extragenital mixed malignant Mullerian tumour presenting as a painful splenic mass: A case report and review of the literature

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World Journal of Obstetrics and Gynecology 2019年第2期8卷 13-24页

作者： Allan Mun Fai Kwok Department of Surgery Wollongong Hospital

BACKGROUND Mixed malignant Mullerian tumours(MMMTs)are highly aggressive cancers that present at a late stage and are associated with a poor long-term *** are characterised by the presence of both epithelial and sarcomatous tissue types on histological examination and hence are known as biphasic tumours or *** almost always arise in the female genital tract(most commonly the uterus)but extragenital sites are also *** options are limited and usually consists of surgery and adjuvant *** SUMMARY A 74-year-old woman presented with a 1-wk history of worsening left upper quadrant abdominal pain and a perisplenic mass on computed tomography(CT)*** on imaging raised the possibility of a malignant process but were not *** was performed and histology confirmed the presence of a mixed malignant Mullerian tumour.A subsequent pelvic ultrasound identified another heterogenous cystic mass in the Pouch of Douglas without evidence of primary pathology in the uterus or adnexa.A second operation was performed for this with curative intent but previously-unknown widespread metastases were encountered at laparotomy.A biopsy of the pelvic mass confirmed it was also a MMMT with identical histological features to the perisplenic *** was no clinical or histological evidence of the MMMT having arisen primarily from the female genital *** patient subsequently suffered multi-organ failure and was palliated,succumbing to death on the 19th post-operative *** Primary extragenital MMMT arising from the spleen or peritoneum represents an atypical form of an already rare gynaecological tumour.

关键词： Mixed malignant Mullerian tumour Carcinosarcoma extragenital Spleen Metastatic Case report

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