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Effects of extract from ginkgo biloba on carbon tetrachloride-induced liver injury in rats

World Journal of Gastroenterology 2006年第24期12卷 3924-3928页

作者： Shui-Xiang He Jin-Yan Luo Yue-PengWang Yan-Li Wang Han Fu Jun-Li Xu Gang Zhao En-Qi Liu Department of Gastroenterolgy Second Affiliated Hospital Xi'an Jiaotong University School of Medical Xi'an 710001 Shaanxi Province China Department of Gastroenterolgy First Affiliated Hospital Xi an Jiaotong University School of Medical Xi'an 710061 Shaanxi Province China Experimental Animal Center Xi'an Jiaotong University School of Medical Xi'an 710061 Shaanxi Province China

AIM： To study the effects of extract from ginkgo biloba （EGb） containing 22% flavonoid and 5% terpenoid on chronic liver injury and liver fibrosis of rats induced by carbon tetrachloride （CCh）. METHODS： All rats were randomly divided into control group, CCl4-treated group, colchicine-treated group and EGb-protected group. Chronic liver injury was induced in experimental groups by subcutaneous injection of CCh and fed with chows premixed with 79.5% corn powder, 20% lard and 0.5% cholesterol （v/v）. EGb-protected group was treated with EGb （0.5 g/kg body weight per day） for 7 wk. At the end of wk 8, all the rats were killed. Liver function, liver fibrosis, oxidative stress and expression of transforming growth factor β1 （TGF-β1） a-smooth muscle actin （α-SMA） and type I collagens in liver were determined. In addition, pathology changes of liver tissue were observed under light microscope. RESULTS： The levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and albumin （AIb） in EGb-protected group were notably improved as compared with the CCL4-treated group （P 〈 0.01）. The contents of serum hyaluronic acid （HA）, type III procollagen （PCⅢ）, type IV collagen （CIV） and the expression of hepatic tissue TGF-β1, α-SMA and type I collagen in EGb-protected group were significantly lower than those in CCL4-treated groups （P 〈 0.05, P 〈 0.01）. The degrees of liver fibrosis in EGb-protected groups were lower than those in CCL4-treated groups （6.58 ±1.25 vs 9.52 ± 2.06, P 〈 0.05）. Compared to the CCL4-treated group, the levels of plasma glutathoine peroxidase （Se-GSH-Px）, superoxide dismutase （SOD） and malondialdehyde （MDA） were strikingly improved also in EGb-protected group （P 〈 0.05, P 〈 0.01）. CONCLUSION： EGb resists oxidative stress and thereby reduces chronic liver injury and liver fibrosis in rats with liver injury induced by CCl4.

关键词： Rats Hepatic fibrosis Chronic liver damage extract from ginkgo biloba Lipid peroxidation

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