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Role of Neutrophil extracellular traps in Asthma and Chronic Obstructive Pulmonary Disease

Chinese Medical Journal 2017年第6期130卷 730-736页

作者： Ting Liu Fa-Ping Wang Geng Wang Hui Mao Department of Respiratory Medicine West China Hospital Sichuan University Chengdu Sichuang 610041 China

Objective： Asthma and chronic obstructive pulmonary disease （COPD） are representative chronic inflammatory airway diseases responsible for a considerable burden of disease. In this article, we reviewed the relationship between neutrophil extracellular traps （NETs） and chronic inflammatory airway diseases. Data Sources： Articles published up to January 1, 2017, were selected from the PubMed, Ovid Medline, Embase databases, with the keywords of＂asthma＂ or ＂pulmonary disease, chronic obstructive＂, ＂neutrophils＂ and ＂extracellular traps.＇＂ Study Selection： Articles were obtained and reviewed to analyze the role of NETs in asthma and COPD. Results： NETs are composed of extracellular DNA, histones, and granular proteins, which are released from activated neutrophils. Multiple studies have indicated that there are a large amount of NETs in the airways of asthmatics and COPD patients. NETs can engulf and kill invading pathogens in the host. However, disordered regulation of NET lbrmation has shown to be involved in the development of asthma and COPD. An overabundance of NETs in the airways or lung tissue could cause varying degrees of damage to lung tissues by inducing the death of human epithelial and endothelial cells, and thus resulting in impairing pulmonary function and accelerating the progress of the disease. Conclusions： Excessive NETs accumulate in the airways of asthmatics and COPD patients. Although NETs play an essential role in the innate immune system against infection, excessive components of NETs can cause lung tissue damage and accelerate disease progression in asthmatics and COPD patients. These findings suggest that administration of NETs could be a novel approach to treat asthma and COPD. Mechanism studies, clinical practice, and strategies to regulate neutrophil activation or directly interrupt NET thnction in asthmatics and COPD patients are desperately needed.

关键词： Asthma Pulmonary Disease, Chronic Obstructive extracellular traps Neutrophils

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Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis:Current Knowledge and Future Perspectives

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Current Medical Science 2024年第1期44卷 1-27页

作者： Qi PAN Cheng CHEN Yue-jin YANG State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China

Atherosclerosis(AS)is characterized by impairment and apoptosis of endothelial cells,continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells,which is documented as the traditional cellular ***,the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis,transdifferentiation and novel cell death forms such as ferroptosis,pyroptosis,and extracellular trap were *** of novel pathological cellular landscapes provides a large number of therapeutic *** the other side,the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS *** cell-or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse *** the complexity of pathological changes of AS,attempts to develop an almighty medicine based on single mechanisms could be theoretically *** this review,the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical *** future challenges and improvements were also discussed.

关键词： atherosclerosis transdifferentiation extracellular traps efferocytosis stem cell nanoparticles

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Noncanonical intercellular communication in immune response

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World Journal of Immunology 2016年第1期6卷 67-74页

作者： Malgorzata Kloc Jacek Z Kubiak Xian C Li Rafik M Ghobrial Department of Surgery Methodist Hospital Houston Methodist Research Institute Centre National de la Recherche Scientifique Unités Mixtes de Recherche 6290 Institute of Genetics and Development of RennesCell Cycle GroupFaculty of Medic-ineUniversity of Rennes Faculty of Medicine University of Rennes 1 Sherrie and Alan Conover Center for Liver Disease and Transplantation

The classical view of signaling between cells of immune system includes two major routes of intercellular communication:Through the release of extracellular molecules or a direct interaction between membrane bound receptor and its membrane bound ligand,which initiate a cascade of signaling in target ***,recent studies indicate that besides these canonical modes of signaling there are also noncanonical routs of intercellular communications through membrane stripping/membrane exchange/trogocytosis,extracellular traps,exosomes and ectososmes/*** this review we discuss what are the components of noncanonical pathways of signaling and what role they play in immune cells interactions.

关键词： Trogocytosis Membrane stripping extracellular traps Exosomes Ectososmes Microparticles

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