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Efficacy and outcome of extensive intraoperative peritoneal lavage plus surgery vs surgery alone with advanced gastric cancer patients

引用

World Journal of Gastrointestinal Surgery 2023年第3期15卷 430-439页

作者： En-Dong Song Heng-Bo Xia Li-Xiang Zhang Jun Ma Pan-Quan Luo Lai-Zhi Yang Ben-Hong Xiang Bai-Chuan Zhou Lei Chen Hui Sheng Yin Fang Wen-Xiu Han Zhi-Jian Wei A-Man Xu Department of General Surgery The First People’s Hospital of Wuhu CityWuhu 241000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Surgical Oncology Anqing Municipal HospitalAnqing 246000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Obstetrics and Gynecology East Hospital Area of Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most common malignant *** resection,one of the major problems is its peritoneal dissemination and *** free cancer cells may still exist after *** addition,the surgery itself may lead to the dissemination of tumor ***,it is necessary to remove residual tumor ***,some researchers found that extensive intraoperative peritoneal lavage(EIPL)plus intraperitoneal chemotherapy can improve the prognosis of patients and eradicate peritoneal free cancer for GC ***,few studies explored the safety and long-term outcome of EIPL after curative *** To evaluate the efficacy and long-term outcome of advanced GC patients treated with *** According to the inclusion and exclusion criteria,a total of 150 patients with advanced GC were enrolled in this *** patients were randomly allocated to two *** patients received *** the non-EIPL group,peritoneal lavage was washed using no more than 3 L of warm *** the EIPL group,patients received 10 L or more of saline(1 L at a time)before the closure of the *** surviving rate analysis was compared by the Kaplan-Meier *** prognostic factors were carried out using the Cox appropriate hazard *** The basic information in the EIPL group and the non-EIPL group had no significant *** median follow-up time was 30 mo(range:0-45 mo).The 1-and 3-year overall survival(OS)rates were 71.0%and 26.5%,*** symptoms of ileus and abdominal abscess appeared more frequently in the non-EIPL group(P<0.05).For the OS of patients,the EIPL,Borrmann classification,tumor size,N stage,T stage and vascular invasion were significant *** multivariate analysis revealed that EIPL,tumor size,vascular invasion,N stage and T stage were independent prognostic *** prognosis of the EIPL group was better than the non-EIPL group(P<0.001).The 3-year survival rate of

关键词： extensive intraoperative peritoneal lavage Advanced gastric cancer Prognosis Recurrence Overall survival

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