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Maternal and Fetal exposure to Four Carcinogenic Environmental Metals

Biomedical and Environmental Sciences 2010年第6期23卷 458-465页

作者： HUAI GUAN FENG-YUAN PIAO XIAO-WEI LI QIU-JUAN LI LEI XU KAZUHITO YOKOYAMA Department of Occupational and Environmental Health Dalian Medical University Dalian 116044 Liaoning China Department of Obstetrics and Gynecology No. 210 Hospital of PLA Dalian 116021 Liaoning China Department of Public School of Medicine Mie University Tsu Mie-Prefecture Japan

Objective To examine maternal and fetal exposure levels to four carcinogenic metals, arsenic （As）, cadmium （Cd）, nickel （Ni）, and beryllium （Be）, and to investigate their environmental influences. Methods Metal concentrations in maternal and umbilical cord blood were measured by inductively coupled plasma-mass spectrometry （ICP-MS）. Environmental factors that might play a role in exposure were analyzed using Mann Whitney nonparametric U-tests and multiple linear regression. Results The concentrations of As, Cd, and Ni in umbilical cord blood （5.41, 0.87, and 139.54 gg/L） were significantly lower than those in maternal blood （6.91, 1.93, and 165.93 p.g/L）. There were significant positive correlations between the maternal and cord concentrations of each carcinogen. Our results showed that：（i） exposures to potentially harmful occupational factors during pregnancy were associated with high levels of maternal As, Cd, and Ni; （ii） living close to major transportation routes （〈500 m） or exposure to second-hand smoke during pregnancy increased the maternal Cd levels and （iii） living close to industrial chimneys induced high maternal Ni levels. Multiple linear regression analysis showed that these environmental factors remained significant in models of the influences of these four carcinogens. Conclusion Both mothers and fetuses had been exposed to As, Cd, Ni, and Be. The increased levels of these carcinogens in pregnant women were associated with some detrimental environmental factors, such as occupational exposure, contact with second-hand smoke and living close to major transportation routes or industrial chimneys.

关键词： Carcinogenic metals exposure in utero Maternal blood Cord blood Environment

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