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Comprehensive analysis of advanced glycation end-products in commonly consumed foods:presenting a database for dietary AGEs and associated exposure assessment

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Food Science and Human Wellness 2024年第4期13卷 1917-1928页

作者： Qiaozhi Zhang Huatao Li Ruixing Zheng Lili Cao Shufen Zhang Shuifeng Zhang Huadong Sheng Yuhao Jiang Yanbo Wang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Ningbo Academy of Product and Food Quality Inspection(Ningbo Fibre Inspection Institute) Ningbo 315048China National Pre-packaged Food Quality Supervision and Inspection Center(Zhejiang) Zhejiang Fangyuan Test Group Co.Ltd.Hangzhou 310018China

Advanced glycation end-products(AGEs)are a group of heterogeneous compounds formed in heatprocessed foods and are proven to be detrimental to human ***,there is no comprehensive database for AGEs in foods that covers the entire range of food categories,which limits the accurate risk assessment of dietary AGEs in human *** this study,we first established an isotope dilution UHPLCQq Q-MS/MS-based method for simultaneous quantification of 10 major AGEs in *** contents of these AGEs were detected in 334 foods covering all main groups consumed in Western and Chinese populations.Nε-Carboxymethyllysine,methylglyoxal-derived hydroimidazolone isomers,and glyoxal-derived hydroimidazolone-1 are predominant AGEs found in most *** amounts of AGEs were high in processed nuts,bakery products,and certain types of cereals and meats(>150 mg/kg),while low in dairy products,vegetables,fruits,and beverages(assessment of estimated daily intake implied that the contribution of food groups to daily AGE intake varied a lot under different eating patterns,and selection of high-AGE foods leads to up to a 2.7-fold higher intake of AGEs through daily *** presented AGE database allows accurate assessment of dietary exposure to these glycotoxins to explore their physiological impacts on human health.

关键词： Advanced glycation end-products Maillard reaction Processed foods Dietary database exposure assessment

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Benzene and lead exposure assessment among occupational bus drivers in Bangkok traffic

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Journal of Environmental Sciences 2004年第1期16卷 61-66页

作者： SHING TET LEONG PREECHA LAORTANAKUL Research Lab Supervisor Urban Environmental Engineering and Management ProgramSchool of EnvironmentResource and DevelopmentAsian Institute of TechnologyAffiliated Research Associate G.P.O. Box 4 Klong Luang Pathumthani 12120 Thailand216 Soi Satsana 5 Phya Thai Bangkok 10400 Thailand

Four environmental and biological monitoring sites were strategically established to evaluate benzene and lead exposure assessment at various traffic zones of Bangkok Metropolitan Region(BMR). Biological measurement of 48 non air-conditioned, male bus drivers was carried to study the relationship between individual exposure levels and exposure biomarkers. The study group was further sub-divided into four age groups(16—25, 26—35, 36—45 and 46—55 years old) to monitor the age—related exposure effects. A total of 12 unexposed persons were deliberately chosen as the control group. Measurement of unmetobolized benzene in blood and analysis of urinary tt-Muconic acid urine and urinary creatinine are recommended as biomarkers of benzene exposure. Measurement of lead in blood and urine is also recommended for the biological monitoring of lead exposure. During the monitoring period, benzene and lead levels at Yaowarat Road was C_6H_6: 42.46±3.88 μg/m 3, Pb: 0.29±0.03 μg/m 3 and decreased to C_6H_6: 33.5±1.35 μg/m 3, Pb: 0.13±0.01 μg/m 3 at Phahonyothin Road. Significant difference was established between the nonsmoking exposed group and nonsmoking control group for blood benzene concentrations ( P exposures derived from automobile emission.

关键词： benzene and lead measurement biomarkers exposure assessment human biomonitoring unleaded gasoline

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Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population

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Science China Chemistry 2015年第12期58卷 1898-1905页

作者： Xiaowei Li Ke Xie Bing Yue Yunyun Gong Yi Shao Xiaohong Shang Yongning Wu Key Laboratory of Food Safety Risk assessment Ministry of Health China National Center for Food Safety Risk assessment 3. Food Science and Engineering Department Wuhan Polytechnic University 4. Institute for Global Food Security School of Biological Sciences Queen's University of Belfast

This study examined the total arsenic(Ast) and inorganic arsenic(Asi) content in the main rice growing area of China. The results were compared with other countries and then used for dietary exposure assessment. A total of 446 rice samples from 15 main rice-growing provinces and autonomous regions of China were collected and then divided into unpolished and polished rice. Total arsenic and arsenic species were analyzed in a total of 892 subsamples using inductively coupled plasma-mass spectrometry(ICP-MS) and high performance liquid chromatography(HPLC) coupled ICP-MS, respectively. National Ast means were 255 μg/kg of unpolished rice and 143 μg/kg of polished rice. Asi was found to be the predominant species and mean levels were 209 μg/kg of unpolished rice and 108 μg/kg of polished rice, respectively. exposure assessment to Asi in polished rice has been calculated for the margin of exposure(MOE), which highlights the fact that Asi levels in the Chinese rice should arouse public health concern.

关键词： arsenic speciation exposure assessment inorganic arsenic rice

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Occupational exposure assessment of phthalate esters in indoor and outdoor microenvironments

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Journal of Environmental Sciences 2018年第10期30卷 75-88页

作者： Meng Xia Xingzi Ouyang Xueqing Wang Xueyou Shen Yu Zhan College of Environmental & Resource Sciences Zhejiang UniversityHangzhou Zhejiang 310058 China Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Hangzhou Zhejiang 310058 China

Phthalate esters（PAEs） are widely used as plasticizers in consumer products. PAEs are a group of environmental hormone which disrupts human and animals＇ endocrine systems. Different occupational groups are exposed to various levels of PAEs. In the present study, four typical occupational groups were chosen, including doctors, college teachers, college students, and drivers who worked in public traffic system. In order to understand the exposure levels to PAEs via inhalation, air samples were collected from multiple microenvironments including indoor and outdoor in Hangzhou to measure the gas and particle concentrations of six PAEs, together with time spent in different microenvironments of these four groups. A comprehensive PAEs exposure model was built to estimate the daily PAEs exposure through inhalation, oral and dermal pathways. The Monte Carlo simulation results show that doctors were exposed to the highest level of PAEs, and consequently had the highest health risk among these four occupational groups. In contrast, college students had the lowest health risk. By setting the exposure level of staying in residences as the baseline, doctors and drivers were two occupations exposed to high PAEs health risk. Di-（2-ethylhexyl） phthalate（DEHP） was the largest contributor among the six phthalates, posing moderate health risk（10-5–10-6） to every occupation. For traffic microenvironments alone, the total exposure levels for different transportation modes were in the descending order of busses, cars, cabs, tubes, motor bikes, and walking.

关键词： Phthalate esters Microenvironment Occupation exposure assessment Uncertainty analysis

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Noise exposure assessment with task-based measurement in complex noise environment

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Chinese Medical Journal 2011年第9期124卷 1346-1351页

作者： LI Nan YANG Qiu-ling ZENG Lin ZHU Liang-liang TAO Li-yuan ZHANG Hua ZHAO Yi-ming Research Center of Clinical Epidemiology Peking University Third Hospital Beijing 100191 China Dongfeng Occupational Disease Prevention and Treatment Institute of Shiyan Shiyan Hubei 442001 China Dongfeng Occupationai Disease Prevention and Treatment Institute of Shiyan Shiyan Hubei 442001 China

Background Task-based measurement （TBM） is a method to assess the eight-hour A-weighted equivalent noise exposure level （LAeq. 8h） besides dosimeter. TBM can be better used in factories by non-professional workers and ***, it is still not clear if TBM is equal or similar with dosimeter for LAeq.8h measurement in general. This study considered the measurement with dosimeter as real personal noise exposure level （PNEL） and assessed the accuracy of TBM by comparing the consistencies of TBM and dosimeter in LAeq.8h *** The study was conducted in one automobile firm among 387 workers who are exposed to unstable *** and TBM were used to compare the two strategies and assess the degree of agreement and causes of disagreement. Worker＇s PNEL was measured via TBM for noise; the real PNEL was also recorded. The TBM for noise was computed with task/position noise levels measured via sound level meter and workers＇ exposure information collected via working diary forms （WDF） filled by participants themselves. Full-shift noise exposure measurement via personal noise dosimeters were taken as the real PNEL. General linear model （GLM） was built to analyze the accuracy of TBM for noise and the source of difference between TBM for noise and real *** The LAeq.8h with TBM were slightly higher than the real PNELs, except the electricians. Differences of the two values had statistical significance in stamping workers （P ＜0.001）, assembly workers （P=0.015） and welding workers （P=0.001）. The correlation coefficient of LAeq.8h with TBM and real PNELs was 0.841. Differences of the two results were mainly affected by real PNEL （F=11.27, P=0.001）; and work groups （F=3.11, P ＜0.001） divided by jobs and workshops were also independent factors. PNEL of workers with fixed task/position （（86.53±8.82） dB（A）） was higher than those without （（75.76±9.92） dB（A））（t=8.84, P ＜0.01）. Whether workers had fixed task/position was another factor on the accuracy of

关键词： task-based measurement noise occupation exposure assessment accuracy feasibility

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exposure assessment of Ambient Sulfur Dioxide Downwind of an Oil Refinery in Curacao

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Journal of Environmental Protection 2018年第3期9卷 194-210页

作者： Erin L.Pulster Giffe Johnson Dave Hollander James McCluskey Raymond Harbison Mote Marine Laboratory SarasotaFLUSA University of South Florida College of Public HealthTampaFLUSA University of South Florida College of Marine ScienceSt.PetersburgFLUSA

Primary sources of atmospheric sulfur dioxide are anthropogenic activities associated with the burning of fossil fuels and industrial processes that may have associations with various morbidities and mortalities. As such, several regional and global regulatory agencies have recommended ambient air limits to reduce environmental exposures. The objectives of this study were to evaluate ambient levels of sulfur dioxide surrounding an oil refinery on the island of Cura?ao. Levels which were then compared to literature values and recommended public health guidelines to determine potential public health risks. Concentrations of sulfur dioxide in Curacao were found to be among the highest globally with an increasing trend over time. While the epidemiological evidence does not conclusively suggest there is a health risk from these levels of exposure, SO2 concentrations greatly exceed regulatory and guidance levels and suggest that further emissions control is warranted. Future recommendations include a more rigorous epidemiological study in Cura?ao and expand the air monitoring efforts to include areas upwind of the refinery as well as additional petrochemical emissions.

关键词： Sulfur Dioxide Oil Refineries Public Health exposure assessment Curacao

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exposure assessment to Indoor Air Pollution in Guiyang

Exposure Assessment to Indoor Air Pollution in Guiyang

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2007中国科协年会

作者： Zhong Ling Yan Min Liu Zhaorong~1 Bai Yuhua College of Environmental Science and Engineering,Peking University,Beijing 100871,China

Research results from epidemiology show that indoor air pollution has tremendous influence on human *** environment is the most important exposure environment to air pollutants as people spend most of their time *** it will contribute a lot to the total air pollutants *** paper introduced and analyzed the basic conception and primary coverage of indoor environmental exposure assessment and made use of data from Indoor Air Quality Investigation in Guiyang to evaluate and discuss the exposure level of indoor air pollutants in Guiyang.

关键词： indoor air pollution exposure assessment Guiyang

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Risk assessment of Veterinary Drug Residues： The Dietary exposure assessment of Benzylpenicillin and Tetracycline Residues in Pork Consumed on Filipino Market

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Journal of Life Sciences 2014年第11期8卷 872-879页

作者： Vutey Venn Vouchsim Kong Borarin Buntong Sopheareth Mao Thong Kong Loinda R. Baldrias Faculty of Veterinary Medicine Royal University of.4griculture Phnom Penh 12401 Cambodia Department of Agro-Industry Ministry of Agriculture Forestry and Fisheries Phnom Penh 12401 Cambodia Faculty of Agro-lndustry Royal University of Agriculture Phnom Penh 12401 Cambodia College of Veterinary Medicine University of the Philippine Los Bahos Laguna 4031 Phillipines

Biological, physical and chemical agents, recognized as food safety hazards, cause potential risks in modem food productions. Although the use of antibiotics in intensive animal productions is impossible to avoid the presence and remaining amount of their residues in food, it is possible to reduce them by using the principles of good veterinary, good manufacturing practices, and continuous control of food and risk assessment approach. This study was conducted to determine exposure risk to antibiotic drug residues in pork consumed in the Philippines and aimed to estimate dietary exposure of benzylpenicillin and tetracycline residues by age and gender groups. Dietary modeling, validated method used, combines food consumption data with food chemical concentration data to estimate dietary exposure to food chemicals. The results had shown that the dietary exposure of benzylpenicillin and tetracycline residues for children from 1 to 〈 3 years old had the highest exposure followed by adolescents, adults and infants while males were significantly lower than females （P 〈 0.05）. This is the initial study to determine risk assessment of dietary exposure to antibiotic residue of different population of Filipino groups.

关键词： exposure assessment pork antibiotic residues age-gender group Philippines.

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Genetic damage and early health effects by chromate based on exposure assessment

Genetic damage and early health effects by chromate based on...

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中国毒理学会第九次全国毒理学大会

作者： HU Gui-ping JIA Guang WANG Tian-cheng FENG Hui-min LI Ping CHEN Zhang-jian LONG Chang-mao ZHENG Pai ZHOU Di Department of Occupational and Environmental Health Sciences School of Public Health Peking University Department of Clinical Laboratory Third Hospital of Peking University

Hexavalent chromium and its compounds are commonly used as industrial material,which are also typical occupational and environmental pollutant. Accumulating epidemiological and experimental studies have shown an increased incidence of cancers associated with chronic exposure to Cr（VI）, such as lung cancer. Exploring the early biomarkers and potential mechanism of genetic damage will promote our understanding of the underlying mechanisms at an early stage of Cr（VI） induced carcinogenesis. In this study, the molecular epidemiological investigation, in vivo and in vitro research are applied on the basis of chromate environmental exposure and biological exposure assessment. It was suggested that the content of chromium in blood and urine could be used as exposure biomarker of chromate biological exposure level. Cr（VI） exposure could result in the changes of multiple elements with respect of their content and relationship among Cr, Cd, Fe, Mg, Mo, Se and Zn in peripheral *** finding was confirmed by the rat experiment treated by repeated intratracheal instillation of Cr（VI）.Meanwhile, chromate-induced genetic damage including 8-OHd G and micronucleus frequency detected by HPLC-MS and cytokinesis block micronucleus cells was observed in chromate exposed ***’s more, miRNA and methylation modification play an important role in chromate caused genetic damage. Hypomethylation of the whole genome and hypermethylation of many different CpG sites in DNA repair genes was observed in chromate exposed workers. Meanwhile there were significant positive correlations between methylation levels of some CpG sites（CpG15, 16, 17, 19 of RAD51, and CpG1 of P16） and the concentration of Cr content in peripheral blood and indexes of genetic damage（8-OHd G or/and micronucleus frequency）, and significant negative correlation between methylation levels of these CpG sites and their gene expression levels. The miR-3940-5 p inhibition by Cr could up-regulate the expression of XRCC2,

关键词： Chromate Biological monitoring exposure assessment Genetic Damage Epigenetic

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Degradation and exposure Risk assessment of Six Sulfonylurea Herbicides in Soil

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Plant Diseases and Pests 2018年第1期9卷 33-37页

作者： Sun Huiqing Qiu Jun Cao Jianmin Kong Fanyu Tobacco Research Institute Chinese Academy of Agricultural Sciences

[Objective] The paper was to understand the degradation tendency and carcinogenic risks of six sulfonylurea herbicides in soil, and guide the safe use. [Method] The herbicide residues were determined by UPLC-MS/MS and the degradation rates were calculated. In addition, the changing tendencies of directly exposed carcinogenic risk along with the herbicide residues were analyzed through the risk evaluation model. [Result] Significant differences were found among the degradation tendencies of the six sulfonylurea herbicides in soil, the longest theoretical half-life was 28.9 d and the shortest was 18.7 d. After application, the maximum carcinogenic risk value of the six herbicide residues in soil was 2.5×10^-8, lower than the reference value （×10^-6）. Oral intake and dermal contact were the major exposure routes, with the total contribution rate of 99.78% to the carcinogenic risk by direct exposure. When the P-value was less than 0.01, both original residue level and carcinogenic risk were significantly correlated with the dosage of herbicide, and the correlation coefficient was 0.983 1. [Conclusion] Under the condition of test, it does not have any unacceptable carcinogenic risk to human body. Moreover, selection of readily degradable herbicide with low residue level, and control of application rate are the effective approaches of reducing the carcinogenic risk of direct exposure.

关键词： Herbicide Residue Degradation exposure assessment Carcinogenic risk

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