检索结果-南通市图书馆

An open air research study of blast-induced traumatic brain injury to goats

Chinese Journal of Traumatology 2015年第5期18卷 267-274页

作者： Hui-Jun Chen Chuan Xu Yue Li Zhi-Qiang Chen Guan-Hua Li Zhao-Xia Duan Xiao-Xia Li Jie-Yuan Zhang Zhe Wang Hua Feng Bing-Cang Li Research Institute of Surgery Daping Hospital. Third Military Medical University Chongqing 400042 China State Key Laboratory of Trauma Burns and Combined Injury Chongqing 400042 China 451 Hospital Chinese People's Liberation Army Xi'an 710054 China Nearosurgery Department Southwest Hospital Third Military Medical University Chongqing 400042 China

Purpose： we once reported blast-induced traumatic brain injury （bTBI） in confined space. Here, bTBI was studied again on goats in the open air using 3.0 kg trinitrotoluene. Methods： The goats were placed at 2, 4, 6 and 8 m far from explosion center. Trinitrotoluene （TNT） was used as the source of the blast wave and the pressure at each distance was recorded. The systemic physiology, electroencephalogram, serum level of S-100beta, and neuron specific enolase （NSE） were determined pre and post the exposure. Neuroanatomy and neuropathology were observed 4 h after the exposure. Results： Simple blast waveforms were recorded with parameters of 702.8 kPa-0.442 ms, 148.4 kPa- 2.503 ms, 73.9 kPa-3.233 ms, and 41.9 kPa-5.898 ms at 2, 4, 6 and 8 m respectively. Encephalic blast overpressure was on the first time recorded in the literature by us at 104.2 kPa-0.60 ms at 2 m, where mortality and burn rate were 44% and 44%. Gross examination showed that bTBI was mainly manifested as congestive expansion of blood vessels and subarachnoid hemorrhage, which had a total incidence of 25% and 19% in 36 goats. Microscopical observation found that the main pathohistological changes were enlarged perivascular space （21/36, 58%）, small hemorrhages （9/36, 25%）, vascular dilatation and congestion （8/36, 22%）, and less subarachnoid hemorrhage （2[36, 6%）. After explosion, serum levels of S- 10013 and NSE were elevated, and EEG changed into slow frequency with declined amplitude. The results indicated that severity and incidence of bTBI is related to the intensity of blast overpressure. Conclusion： blast wave can pass through the skull to directly injure brain tissue.

关键词： Brain injuries explosive blast Open-air field S-100 Neuron specific enolase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：