检索结果-南通市图书馆

An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng Gu Haiyuan Li Baoming Li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling experimental validation PFN

Prediction of preferential fluid flow in porous structures based on topological network models: Algorithm and experimental validation

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2018年第8期61卷 1217-1227页

作者： JU Yang LIU Peng ZHANG DongShuang DONG JiaBin RANJITH P.G. CHANG Chun State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology School of Mechanics and Civil Engineering China University of Mining & Technology School of Resources and Safety Engineering China University of Mining & Technology Institute of Mechanics Chinese Academy of Science Department of Civil Engineering Monash University

The understanding and prediction of preferential fluid flow in porous media have attracted considerable attention in various engineering fields because of the implications of such flows in leading to a non-equilibrium fluid flow in the subsurface. In this study, a novel algorithm is proposed to predict preferential flow paths based on the topologically equivalent network of a porous structure and the flow resistance of flow paths. The equivalent flow network was constructed using Poiseuille's law and the maximal inscribed sphere algorithm. The flow resistance of each path was then determined based on Darcy's law. It was determined that fluid tends to follow paths with lower flow resistance. A computer program was developed and applied to an actual porous structure. To validate the algorithm and program, we tested and recorded two-dimensional(2 D) water flow using an ablated Perspex sheet featuring the same porous structure investigated using the analytical calculations. The results show that the measured preferential flow paths are consistent with the predictions.

关键词： preferential flow porous structure topological networks flow resistance Darcy's law experimental validation

Development and experimental validation of a novel hybrid powertrain with dual planetary gear sets for transit bus applications

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2015年第12期58卷 2085-2096页

作者： QIN KongJian WANG EnHua ZHAO Hang SHI GuangKui WANG RenGuang KONG ZhiGuo WANG Wei State Key Laboratory of Automotive Safety and Energy Tsinghua University China Automotive Technology and Research Center

Given that energy conservation and environmental protection are two important goals for the automotive industry, the application of a hybrid electric powertrain can improve vehicle energy efficiency while decreasing fuel consumption and engine emissions. Planetary gear-based power-split hybrid powertrains have become widely used in passenger vehicles, but remain rarely employed on transit buses. This study proposes a novel hybrid powertrain based on two planetary gear sets(CHS) and presents its operating principles along with development of a control strategy for the powertrain. The CHS hybrid powertrain operates in electric mode when the driving power demand is low, and changes to a hybrid electric mode according to the power-split principle of the planetary gear set. To validate the feasibility of the designed CHS hybrid powertrain, a prototype transit bus equipped with the designed hybrid powertrain system was built, and the operating characteristics of the system were analyzed through a performance test conducted on a chassis dynamometer. Compared with a conventional powertrain, the CHS hybrid powertrain can reduce fuel consumption by 39%. Thus, the CHS hybrid powertrain is a good solution for heavy-duty applications such as hybrid transit buses because of its simple structure and excellent fuel efficiency.

关键词： dual planetary gear set hybrid powertrain experimental validation transit bus performance analysis

Prediction of ground-borne vibration induced by impact pile driving:numerical approach and experimental validation

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2023年第4期22卷 921-935页

作者： A.Colaço P.Alves Costa C.Ferreira C.Parente J.Fernandez-Ruiz CONSTRUCT-FEUP University of PortoRua Dr.Roberto Frias4200-465 PortoPortugal University of La Coruña Department of Civil EngineeringCampus de Elviña 15071La CoruñaSpain

Deep foundations are currently used in engineering practice to solve problems caused by weak geotechnical characteristics of the *** pile driving is an interesting and viable solution from economic and technical points of ***,it is necessary to ensure that the environmental drawbacks,namely ground-borne vibration,are adequately *** this purpose,the authors propose an axisymmetric finite element method-perfectly matched layer(FEM-PML)approach,where the nonlinear behavior of the soil is addressed through an equivalent linear *** the complexity of the problem,an experimental test site was developed and fully *** experimental work comprised in-situ and laboratory soil characterization,as well as the measurement of vibrations induced during pile *** comparison between experimental and numerical results demonstrated a very good agreement,from which it can be concluded that the proposed numerical approach is suitable for the prediction of vibrations induced by impact pile *** experimental database is available as supplemental data and may be used by other researchers in the validation of their prediction models.

关键词： pile driving ground-borne vibrations numerical modeling experimental validation

Configuration design,energy management and experimental validation of a novel series-parallel hybrid electric transit bus

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1269-1276页

作者： Wei-wei XIONG Yong ZHANG Cheng-liang YIN Institute of Automotive Engineering Shanghai Jiao Tong University Shanghai 200240 China

This paper aims to present the configuration design approach and the energy management strategy （EMS） of a series-parallel hybrid electric transit bus （SPHEB） jointly developed by Shanghai Automotive Industry Co. Ltd. （SAIC） and Shanghai Jiao Tong University （SJTU）, China. A major feature of this SPHEB is that a novel manual transmission is designed to switch the powertrain configuration between series and parallel types. To reduce the fuel consumption as well as sustain the battery state of charge, an EMS including seven energy flow modes is designed and applied to this SPHEB. Governed by this EMS, the engine is maintained to operate in high efficiency regions. The experimental test carded on the transit bus city driving cycle is described and analyzed. The experimental results demonstrate the technical feasibility and fuel economy of this approach.

关键词： Series-parallel hybrid bus Powertrain configuration Energy management experimental validation

A Train-Bridge Dynamic Interaction Analysis Method and Its experimental validation

在线全文

学校读者我要写书评

暂无评论

Engineering 2016年第4期2卷 528-536页

作者： Nan Zhang Yuan Tian He Xia School of Civil Engineering BeijingJiaotong University Beijing 100044 China

The train-bridge dynamic interaction problem began with the development of railway technology, and requires an evaluation method for bridge design in order to ensure the safety and stability of the bridge and the running train. This problem is studied using theoretical analysis, numerical simulation, and experimental study. In the train-bridge dynamic interaction system proposed in this paper, the train vehicle model is established by the rigid-body dynamics method, the bridge model is established by the finite element method, and the wheel/rail vertical and lateral interaction are simulated by the corresponding assumption and the Kalker linear creep theory, respectively. Track irregularity, structure deformation, wind load, collision load, structural damage, foundation scouring, and earthquake action are regarded as the excitation for the system. The train-bridge dynamic interaction system is solved by inter-history iteration. A case study of the dynamic response of a CRH380BL high-speed train running through a standard-design bridge in China is discussed. The dynamic responses of the vehicle and of the bridge subsystems are obtained for speeds ranging from 200 km-b-1 to 400 km.h-1, and the vibration mechanism are analyzed.

关键词： Train-bridge dynamic interaction Wheel/rail relationship Inter-history iteration Field measurement experimental validation

A study of miRNAs targets prediction and experimental validation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2010年第11期1卷 979-986页

作者： Yong Huang Quan Zou Haitai Song Fei Song Ligang Wang Guozheng Zhang Xingjia Shen Jiang Su University of Science and Technology Zhenjiang 212018China School of information Science and Technology of Xiamen University Xiamen 361005China The Key Laboratory of Silkworm and Mulberry genetic Improvement Ministry of AgricultureSericultural Research InstituteChinese Academy of Agricultural SciencesZhejiang 212018China

microRNAs(miRNAs)are 20–24 nucleotide(nt)RNAs that regulate eukaryotic gene expression post-transcriptionally by the degradation or translational inhibition of their target messenger RNAs(mRNAs).To identify miRNA target genes will help a lot by understanding their biological *** computational approaches for miRNA target prediction,and effective biological techniques for validating these targets now play a central role in elucidating their *** to the imperfect complementarity of animal miRNAs with their targets,it is difficult to judge the accuracy of the *** of regulation by miRNA-mediated targets at protein and mRNAs levels has made it more challenging to identify the *** date,only a few miRNAs targets are *** this article,we review the methods of miRNA target prediction and the experimental validation for their corresponding mRNA targets in animals.

关键词： microRNA computational prediction target experimental validation

Network pharmacology and experimental validation of Maxing Shigan decoction in the treatment of influenza virus-inducedferroptosis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2023年第10期21卷 775-788页

作者： HUANG Jiawang MA Xinyue LIAO Zexuan LIU Zhuolin WANG Kangyu FENG Zhiying NING Yi LU Fangguo LI Ling College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China The Medicine School of Hunan University of Chinese Medicine Changsha 410208China Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China

Influenza is an acute viral respiratory infection that has caused high morbidity and mortality *** A virus(IAV)has been found to activate multiple programmed cell death pathways,including *** is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation,leading to cell ***,little is known about how influenza viruses induce ferroptosis in the host *** this study,based on network pharmacology,we predicted the mechanism of action of Maxing Shigan decoction(MXSGD)in IAV-induced ferroptosis,and found that this process was related to biological processes,cellular components,molecular function and multiple signaling pathways,where the hypoxia inducible factor-1(HIF-1)signaling pathway plays a significant ***,we constructed the mouse lung epithelial(MLE-12)cell model by IAV-infected in vitro cell experiments,and revealed that IAV infection induced cellular ferroptosis that was characterized by mitochondrial damage,increased reactive oxygen species(ROS)release,increased total iron and iron ion contents,decreased expression of ferroptosis marker gene recombinant glutathione peroxidase 4(GPX4),increased expression of acyl-CoA synthetase long chain family member 4(ACSL4),and enhanced activation of hypoxia inducible factor-1α(HIF-1α),induced nitric oxide synthase(iNOS)and vascular endothelial growth factor(VEGF)in the HIF-1 signaling *** with MXSGD effectively reduced intracellular viral load,while reducing ROS,total iron and ferrous ion contents,repairing mitochondrial results and inhibiting the expression of cellular ferroptosis and the HIF-1 signaling ***,based on animal experiments,it was found that MXSGD effectively alleviated pulmonary congestion,edema and inflammation in IAV-infected mice,and inhibited the expression of ferroptosis-related protein and the HIF-1 signaling pathway in lung tissues.

关键词： Network pharmacology experimental validation Maxing Shigan decoction Influenza Ferroptosis HIF-1 signaling pathway

Therapeutic Mechanism of Kai Xin San on Alzheimer's Disease Based on Network Pharmacology and experimental validation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2023年第5期29卷 413-423页

作者： WANG Kan YANG Rong CHEN Tuan-tuan QIN Mei-rong WANG Ping KONG Ming-wang The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhenGuangdong Province(518033)China Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao SARChina Key Laboratory of Cosmetics Monitoring and Evaluation State Drug AdministrationShenzhen Institute for Drug ControlShenzhenGuangdong Province(518057)China The School of Basic Medical Sciences Hubei University of Chinese MedicineWuhan(430065)China

Objective: To explore the specific pharmacological molecular mechanisms of Kai Xin San(KXS)on treating Alzheimer’s disease(AD) based on network pharmacology and experimental validation. Methods:The chemical compounds of KXS and their corresponding targets were screened using the Encyclopedia of Traditional Chinese Medicine(ETCM) database. AD-related target proteins were obtained from MalaCards database and DisGeNET databases. Key compounds and targets were identified from the compound-targetdisease network and protein-protein interaction(PPI) network analysis. Functional enrichment analysis predicted the potential key signaling pathways involved in the treatment of AD with KXS. The binding affinities between key ingredients and targets were further verified using molecular docking. Finally, the predicted key signaling pathway was validated experimentally. Positioning navigation and space search experiments were conducted to evaluate the cognitive improvement effect of KXS on AD rats. Western blot was used to further examine and investigate the expression of the key target proteins related to the predicted pathway. Results: In total, 38active compounds and 469 corresponding targets of KXS were screened, and 264 target proteins associated with AD were identified. The compound-target-disease and PPI networks identified key active ingredients and protein targets. Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis suggested a potential effect of KXS in the treatment of AD via the amyloid beta(Aβ)-glycogen synthase kinase-3 beta(GSK3β)-Tau pathway. Molecular docking revealed a high binding affinity between the key ingredients and targets. In vivo,KXS treatment significantly improved cognitive deficits in AD rats induced by Aβ1-42, decreased the levels of Aβ, p-GSK3β, p-Tau and cyclin-dependent kinase 5, and increased the expressions of protein phosphatase 1alpha(PP1A) and PP2A(P<0.05 or P<0.01). Conclusion: KXS exerted neuroprotective effects by regulating the

关键词： Kai Xin San Alzheimer's disease Tau protein network pharmacology molecular docking experimental validation Chinese medicine