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Gastroretentive drug delivery systems for the treatment of Helicobacter pylori

World Journal of Gastroenterology 2014年第28期20卷 9321-9329页

作者： Shan Zhao Yan Lv Jian-Bin Zhang Bing Wang Guo-Jun Lv Xiao-Jun Ma Laboratory of Biomedical Material Engineering Dalian Institute of Chemical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences

Helicobacter pylori (H. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population. It is the primary known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. However, combined drug therapy as the general treatment in the clinic, the rise of antibiotic-resistant bacteria, adverse reactions and poor patient compliance are major obstacles to the eradication of H. pylori. Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects. Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug, thereby increasing the concentration of the drug at the application site, potentially improving its bioavailability and reducing the necessary dosage. Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems, bioadhesive systems and expandable systems. In this review, we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time. We then focus on various aspects useful in the development of gastroretentive drug delivery systems, including current trends and the progress of novel forms, especially with respect to their application for the treatment of H. pylori infections.

关键词： Helicobacter pylori Gastroretentive systems Floating systems Bioadhesive systems expandable systems

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