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Pancreatitis and pancreatic cancer:A case of the chicken or the egg

World Journal of Gastroenterology 2021年第23期27卷 3148-3157页

作者： Devica S Umans Sanne A Hoogenboom Noor J Sissingh Selma J Lekkerkerker Robert C Verdonk Jeanin E van Hooft Department of Gastroenterology and Hepatology Amsterdam Gastroenterology and MetabolismAmsterdam UMCAmsterdam 1105 AZThe Netherlands Department of Research and Development St.Antonius HospitalNieuwegein 3430 EMThe Netherlands Department of Gastroenterology and Hepatology Leiden University Medical CenterLeiden 2333 ZAThe Netherlands Department of Gastroenterology and Hepatology St.Antonius HospitalNieuwegein 3430 EMThe Netherlands

Acute pancreatitis(AP),chronic pancreatitis(CP)and pancreatic cancer are three distinct pancreatic diseases with different prognoses and treatment ***,it may be difficult to differentiate between benign and malignant *** may be a first symptom of pancreatic cancer,particularly in patients between the ages of 56 and 75 with presumed idiopathic AP who had a concomitant diagnosis of new-onset diabetes mellitus or patients who present with CP at diagnosis of *** these patients,additional imaging is warranted,preferably by endoscopic *** may lead to pancreatic cancer through oncogenic mutations,mostly in patients with hereditary CP,and in patients in whom risk factors for pancreatic cancer(e.g.,nicotine and alcohol abuse)are also *** with PRSS1-mediated CP and patients with a history of autosomal dominant hereditary CP without known genetic mutations may be considered for surveillance for pancreatic *** inflammation may mimic pancreatic cancer by appearing as a focal mass-forming lesion on *** between the above mentioned benign and malignant disease may be facilitated by specific features like the duct-penetrating sign and the duct-to-parenchyma *** efforts are aimed towards developing a superior discriminant between pancreatitis and pancreatic cancer in the form of imaging modalities or *** may aid clinicians in timely diagnosing pancreatic cancer in a potentially curable stage.

关键词： pancreatic diseases pancreatic neoplasms Pancreatitis Pancreas Chronic Pancreatitis exocrine pancreatic

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