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Optimization of different intensities of exercise preconditioning in protecting exhausted exercise induced heart injury in rats

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Sports Medicine and Health Science 2021年第4期3卷 218-227页

作者： Zheng Ping Weijia Qiu Mei Yang Xiaoli Zhang Dongying Wang Peng Xu Ziwen Wang Xuebin Cao Department of Cardiology and Nephrology Hospital of the 82nd Group Army of PLABaoding071000China

This study was to optimize the exercise preconditioning(EP)intensity in protecting from exhaustive exercise-induced cardiac injury(EECI).A total of 98 male Sprague-Dawley rats were divided into 7 groups(n=14):the control group(C),the exhaustive exercise group(EE)and the EP+EE groups,which include the V10(53.0%VO_(2max)),V15(58.4%VO_(2max)),V20(67.0%VO_(2max)),V26(74.0%VO_(2max))and V30(80.0%VO_(2max))*** the C group,the other groups were subjected to treadmill *** serum contents of N terminal pro B type natriuretic peptide(NT-proBNP)and cardiac troponin I(cTn-I)were detected by the enzyme-linked immunosorbent assay method,ECG was recorded,heart function was detected by pressure volume catheter and the activities of mitochondrial electron transfer pathway(ET pathway)complexesⅠ,ⅡandⅣwere measured by high-resolution respiration *** to the EE group,the EP groups have shown decrease of NT-proBNP and cTn-I,improvement of mitochondrial respiratory function and car-diac *** to other EP groups,the V26 group has shown significant decrease of myocardial enzymes and improvement of mitochondrial *** correlation analysis showed the EP effect was proportional to EP intensity in the range of 53.0%VO_(2max)-74.0%VO_(2max).High intensity and long duration of exhaustive exercise caused cardiac injury and EP could decrease serum level of NT-proBNP and cTn-I,improve electrical derangement and the left ventricular function,and raise the activities of ET pathway complexesⅠ,ⅡandⅣ.The protection of EP on EECI was improved as the EP intensity was increased from 53.0%VO_(2max)to 74.0%VO_(2max)and when EP intensity was 74.0%VO_(2max),the effect was the most obvious among all the setting EP groups.

关键词： exercise preconditioning exhaustive exercise-induced cardiac injury Mitochondrial respiratory function

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