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Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons

Neuroscience Bulletin 2019年第3期35卷 497-506页

作者： Qiang-Qiang Xia Jing Xu Tai-Lin Liao Jie Yu Lei Shi Jun Xia Jian-Hong Luo Junyu Xu Department of Neurobiology Institute of NeuroscienceNHC and CAMS Key Laboratory of Medical NeurobiologyZhejiang University School of MedicineHangzhou 31005& China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research. Jinan University Guangzhou 510632China Division of Life Science Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience. The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Neuroligins(NLs) are postsynaptic cell-adhesion proteins that play important roles in synapse formation and the excitatory-inhibitory balance. They have been associated with autism in both human genetic and animal model studies, and affect synaptic connections and synaptic plasticity in several brain regions. Yet current research mainly focuses on pyramidal neurons, while the function of NLs in interneurons remains to be understood. To explore the functional difference among NLs in the subtypespecific synapse formation of both pyramidal neurons and interneurons, we performed viral-mediated shRNA knockdown of NLs in cultured rat cortical neurons and examined the synapses in the two major types of neurons. Our results showed that in both types of neurons, NL1 and NL3 were involved in excitatory synapse formation, and NL2 in GABAergic synapse formation. Interestingly, NL1 affectedGABAergic synapse formation more specifically than NL3,and NL2 affected excitatory synapse density preferentially in pyramidal neurons. In summary, our results demonstrated that different NLs play distinct roles in regulating the development and balance of excitatory and inhibitory synapses in pyramidal neurons and interneurons.

关键词： Neuroligin Synapse formation excitatory/inhibitory balance Interneuron

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