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Clinical features of multiple gastrointestinal stromal tumors:A pooling analysis combined with evidence and gap map

World Journal of Gastroenterology 2020年第47期26卷 7550-7567页

作者： Chen Li Ke-Lu Yang Quan Wang Jin-Hui Tian Yang Li Zhi-Dong Gao Xiao-Dong Yang Ying-Jiang Ye Ke-Wei Jiang Department of Gastroenterological Surgery Peking University People's HospitalBeijing 100044China evidence-Based Nursing Center School of NursingLanzhou UniversityLanzhou 730000Gansu ProvinceChina evidence Based Medicine Center School of Basic Medical Science of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are a very rare type of gastrointestinal stromal tumor(GIST)and are usually observed in *** The paper aimed to describe the clinical and oncological features of MGISTs and to offer evidence for the diagnosis and *** Data of consecutive patients with MGISTs who were diagnosed at Peking University People’s Hospital(PKUPH)from 2008 to 2019 were retrospectively ***,a literature search was conducted by retrieving data from PubMed,EMBASE,and the Cochrane library databases from inception up to November 30,*** In all,12 patients were diagnosed with MGISTs at PKUPH,and 43 published records were ultimately included following the literature *** analysis of the whole individual patient data showed that female(59.30%),young(14.45%),and syndromic GIST(63.95%)patients comprised a large proportion of the total patient *** were mainly located in the small intestine(58.92%),and both CD117 and CD34 were generally *** a mean 78.32-mo follow-up,the estimated median overall survival duration(11.5 years)was similar to single GISTs,but recurrence-free survival was relatively *** The clinical and oncological features are potentially different between MGISTs and single *** studies are needed to explore appropriate surgical approach and adjuvant therapy.

关键词： Gastrointestinal stromal tumor Multiple Pooling analysis Cross sectional study evidence and gap map

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