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Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening

Chinese Journal of Natural Medicines 2018年第2期16卷 125-130页

作者： Babar Ali Mohammad Ali Saima Amin Showkat R.Mir College of Pharmacy and Dentistry Buraydah Colleges Phytopharmaceuticals Research Lab Department of Pharmacognosy and Phytochemistry School of Pharmaceutical Education and Research (Formerly Faculty of Pharmacy) Jamia Hamdard

The seeds of Nigella sativa Linn.(Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5-β-D-glucofuranosyl(2→1)-β-D-glucopyranosyl-(2→1)-β-D-glucopyranoside]] and nigelabdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl-β-D-glucopyranosyl(2→1)-β-D-glucopyranosyl(2→1)-β-D-glucopyranoside], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract. The structures of these new glycosides were elucidated by detailed spectroscopic analyses.

关键词： Nigella sativa everted rat sac Homolabdane Amoxicillin Bioavailability

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Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

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Pharmacology & Pharmacy 2019年第3期10卷 146-158页

作者： Mei Ge Xihong Hou Shimeng Li Kunpeng Liu Ziyi Han Siyu Hao Zhongliang Zeng Yingchun Zhang College of Pharmaceutical Sciences and Chinese Medicine Southwest University Chongqing China

Cortex Moutan (Paeonia suffruticosa Andr.) is a common traditional Chinese medicine and has been widely used in clinic for 2000 years in China. As sources for this crude drug are always mixed with other species, many cultivars on herbal market may lead to quality instability. Multi-component quantitative analysis is an efficient method to reflect chemical profiles of herb medicine and is always taken as the main method for quality evaluation. So, the aim of this work is to develop analytical method to quantify paeonol, paeoniflorin, gallic acid, oxypaeoniflorin, benzoylpaeoniflorin and paeonolide in Cortex Moutan (CM) to evaluate the chemical qualities of CM from different species or cultivars. Besides, we also study the intestinal absorption characteristics of paeonol and paeoniflorin for further pharmacological evaluation. In the present study, all of the standard markers were performed on an Ecosil C18 (250 mm × 4.6 mm, 5 μM, Lubex Co., Guangzhou, China) with linear gradient elution of 0.2% formic acid water and acetonitrile. The proposed method was applied to analyze 50 batches of samples with acceptable linearity (R2, 0.9995 - 0.9999), precisions (RSD, 0.47% - 2.08%), repeatability (RSD, 039% - 2.63%), stability (RSD, 0.52% - 2.45%), and recovery (RSD, 0.72% - 3.03%) of the six compounds. Furthermore, the Hierarchical Cluster Analysis was applied to classify the 50 samples based on contents of the six compound markers. The results obtained from multi-component quantification of CM clearly indicated that CM originated from P. suffruticosa and P. ostii presented different chemical properties, and that samples from the two materials could be gathered into one branch, respectively, while CM sourced from cultivars of P. suffruticosa showed great variety on chemical quality. The results from Hierarchical Cluster Analysis implied that the established method could be used as a powerful tool for the quality evaluation of CM. The intestinal absorption study indicated tha

关键词： Cortex Moutan Paeonol Paeoniflorin everted Intestinal Sac HPLC-MS

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