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ethanol Increases Mechanical pain Sensitivity in Rats via Activation of GABA_A receptors in Medial Prefrontal Cortex

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Neuroscience Bulletin 2016年第5期32卷 433-444页

作者： Kai-Wen Geng Ting He Rui-Rui Wang Chun-Li Li Wen-Jun Luo Fang-Fang Wu Yan Wang Zhen Li Yun-Fei Lu Su-Min Guan Jun Chen Institute for Biomedical Sciences of pain and Institute for Functional Brain Disorders Tangdu Hospital The Fourth Military Medical University Xi'an 710038 China Key Laboratory of Brain Stress and Behavior People's Liberation Army Xi'an 710038 China Beijing Institute for Brain Disorders Beijing 100069 China School of Stomatology The Fourth Military Medical University Xi'an 710032 China

ethanol is widely known for its ability to cause dramatic changes in emotion, social cognition, and behavior following systemic administration in *** neuroimaging studies suggest that alcohol dependence and chronic pain may share common mechanisms through amygdala-medial prefrontal cortex（m PFC） interactions. However, whether acute administration of ethanol in the m PFC can modulate pain perception is *** we showed that bilateral microinjections of ethanol into the prelimbic and infralimbic areas of the m PFC lowered the bilateral mechanical pain threshold for 48 h without influencing thermal pain sensitivity in adult ***, bilateral microinjections of artificial cerebrospinal fluid into the m PFC or bilateral microinjections of ethanol into the dorsolateral PFC（also termed as motor cortex area 1 in Paxinos and Watson＇s atlas of The Rat Brain. Elsevier Academic Press, Amsterdam, 2005） failed to do so, suggesting regional selectivity of the effects of ethanol. Moreover, bilateral microinjections of ethanol didnot change the expression of either pro-apoptotic（caspase-3 and Bax） or anti-apoptotic（Bcl-2） proteins, suggesting that the dose was safe and validating the method used in the current study. To determine whether c-aminobutyric acid A（GABA_A） receptors are involved in mediating the ethanol effects, muscimol, a selective GABA_Areceptor agonist, or bicuculline, a selective GABA_A receptor antagonist, was administered alone or co-administered with ethanol through the same route into the bilateral m PFC. The results showed that muscimol mimicked the effects of ethanol while bicuculline completely reversed the effects of ethanol and muscimol. In conclusion, ethanol increases mechanical pain sensitivity through activation of GABA_A receptors in the m PFC of rats.

关键词： ethanol mpfc pain perception gabaa receptor empathy

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