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Changes of estrogen in Serum and estrogen receptor β in the Relevant Brain Regions Following Mating Behavior of the Male Mandarin Vole Microtus mandarinus

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Zoological Research 2008年第5期29卷 529-536页

作者：何凤琴张巨武石靖王波西安文理学院生命科学系西安710065

In order to investigate the estrogen and estrogen receptor β changes after mating behavior of male mandarin vole （Microtus mandarinus）, the radioimmunoassay （RIA） and immunohistochemistry methods were used to investigate changes of the serum estrogen （E） concentrations, estrogen immunoreactive neurons （E-IRs） and estrogen receptor β immunoreactive neurons （ERβ-IRs） in the relevant brain regions following mating behavior. Fifteen sexually matured male voles were randomly divided into three groups and treated differently：（1） control group： voles were exposed to clean hard-wood shavings （n=5）, （2） exposure group： voles were exposed to the soiled bedding for more than 24h on which estrous females had been placed （n=5）, and （3） mating group： voles were placed with an estrous female for more than 24h （n=5）. The results showed circulating serum E concentrations were significantly higher in the mating group than in the exposure group and the control group, and there were no significant difference between the exposure group and the control group. E-IRs and ERβ-IRs were detected in the following brain regions related to mating behavior： the arcuate nucleus （ARC）, bed nucleus of the stria terminalis （BST）, lateral septal nucleus （LS）, medial amygdaloid nucleus （ME）, medial preoptic area （MPO） and ventromedial hypothalamic nucleus （VMH）. The results showed that there were significantly more E-IRs in the six brain regions in the mating group than in the control group and the exposure group, and there were no significant difference between the exposure group and the control group except for LS. There was no significant difference in ERβ-IRs in the six brain regions among the three groups, and there were some lighter -stained ERβ-IRs in these brain regions. The results suggested that estrogen affect mating activity of male mandarin voles, but ERβ might not play an important role in mating behavior of male mandarin voles. Instead, it might be through other receptors.

关键词： Mandarin voles (Microtus mandarinus): estrogen estrogen receptor β Radioimmunoassay Mating behavior

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Placental expressions of estrogen receptor α,estrogen receptor β in intrahepatic cholestasis of pregnancy

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Journal of Medical Colleges of PLA(China) 2011年第5期26卷 271-278页

作者： Zon Lu Yang Ting Department of Gynecology and Obstetrics First Affiliated Hospital Medical School of Xi ＂an Jiaotong University Xi＇an 710061 China

To investigate the association of the expression of estrogen receptor ct, estrogen receptor 13 in placenta with intrahepatic cholestasis of pregnancy （ICP） susceptibility. Methods： In 14 cases of mild ICP, 14 cases of severe ICP and 14 cases of normal cases （control group） with corresponding age and gestation weeks, the expressions of ERa and ERD were detected by means of immunohistochemical method S-P. Results： The mean grey numbers of ERa in each group mentioned above were 151.684±3.76, 149.854±3.69, 153.184±3.18, without significant difference （P〉0.05） The mean grey numbers of ERβ in each group mentioned above were 146.51±3.81, 139.434±9.97, 149.87±4.17, with significant difference （P〉0.05）; the expression of ERI3 of severe ICP group was significantly higher than that of the mild ICP group and the control group （P〈0.05）. The expression of ERβ in every group was higher than that of ERa （P〈0.05）. Conclusion： ERβ maybe play an important part in the etiology and development of ICP

关键词： estrogen receptor a estrogen receptor β Intrahepatic cholestasis of pregnancy Placenta

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Association of a cytosine-adenine repeat polymorphism in the estrogen receptor β gene with occurrence and severity of rheumatoid arthritis

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Open Journal of Internal Medicine 2013年第1期3卷 3-7页

作者： Kanako Watanabe Hiromi Sato Ayano Ito Tomomi Sato Aránzazu González-Canga Hana Sugai Masahiko Suzuki Takao Namiki Koichi Ueno Department of Geriatric Pharmacology and Therapeutics Graduate School of Pharmaceutical SciencesChiba UniversityChibaJapan Assessment Area Medicines for Veterinary Use DepartmentAgencia Espanola de Medicamentosy Productos Sanitarios(AEMPS)MadridSpain Research Center for Frontier Medical Engineering Chiba UniversityChibaJapan Department of Frontier Japanese-Oriental(Kampo)Medicine Graduate School of MedicineChiba UniversityChibaJapan

We investigated the influence of the cytosine-adenine (CA) dinucleotide repeat polymorphism in intron 6 of estrogen receptor β (ERβ) gene on rheumatoid arthritis (RA) risk. One hundred and ninety-three RA patients and 77 control subjects with osteoarthritis (OA) were recruited. The CA repeat polymorphism was assayed by a dye-terminator cycle sequencing analysis. No statistically significant difference in the mean number of CA repeats between the RA and OA patients was observed (RA: 21.47, OA: 21.23, P = 0.324). The alleles were categorized according to the number of repeats: short (S, ≦21) and long (L, ≧22), in which the genotypes SS, SL, and LL were observed. No significant differences were observed for the allele and genotype distributions of this polymorphism in both patient groups. The RA patients were classified according to RA severity: mild (least erosive disease) and severe (more erosive and mutilating disease). Again, no significant difference in genotype frequency between these groups was observed, even after stratifying by sex. The present study indicates that additional studies are needed to clarify the roles of this polymorphism, estrogen, and ER in the development of autoimmune diseases.

关键词： Polymorphism Rheumatoid Arthritis Sex estrogen receptor β CA Repeat

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Overexpression of estrogen receptor beta alleviates the toxic effects of beta-amyloid protein on PC12 cells via non-hormonal ligands

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Neural Regeneration Research 2012年第14期7卷 1095-1100页

作者： Hui Wang Lihui Si Xiaoxi Li Weiguo Deng Haimiao Yang Yuyan Yang Yan Fu Department of Gynaecology and Obstetrics First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Gynaecology and Obstetrics Second Hospital of Jilin University Changchun 130044 Jilin Province China Department of Gynaecology Affiliated Hospital of Changchun University of Traditional Chinese Medicine Changchun 130021 Jilin Province China Department of Children＇s Heatlh School of Public Health Jilin Univeristy Changchun 130021 China Department of Scientific Research Affiliated Hospital of Changchun University of Traditional Chinese Medicine Changchun 130021 China Department of Gynaecology and Obstetrics Minzu Hospital of Yitong County Yitong 130700 Jilin Province China

After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer＇s disease patients. estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical treatment of Alzheimer＇s disease. There is recent evidence that the estrogen receptor can exert its neuroprotective effects without estrogen dependence. Real-time quantitative PCR and flow cytometry results showed that, compared with non-transfected PC12 cells, adenovirus-mediated estrogen receptor β gene-transfected PC12 cells exhibited lower expression of tumor necrosis factor a and interleukin 1β under stimulation with beta-amyloid protein and stronger protection from apoptosis. The Akt-specific inhibitor Abi-2 decreased the anti-inflammatory and anti-apoptotic effects of estrogen receptor β gene-transfection. These findings suggest that overexpression of estrogen receptor β can alleviate the toxic effect of beta-amyloid protein on PC12 cells, without estrogen dependence. The Akt pathway is one of the potential means for the anti-inflammatory and anti-apoptotic effects of the estrogen receptor.

关键词： estrogen estrogen receptor β Alzheimer's disease beta-amyloid protein adenovirus neural regeneration

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estrogen receptor beta treats Alzheimer's disease

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Neural Regeneration Research 2013年第5期8卷 420-426页

作者： Zhu Tian Jia Fan Yang Zhao Sheng Bi Lihui Si Qun Liu Department of Neurology the First Hospital of Jilin University Department of Neurology the Second Hospital of Jilin University Department of Obstetrics and Gynecology the Second Hospital of Jilin University

In vitro studies have shown that estrogen receptor β can attenuate the cytotoxic effect of amyloid protein on PC12 cells through the Akt pathway without estrogen stimulation. In this study, we aimed to observe the effect of estrogen receptor β in Alzheimer＇s disease rat models established by intraventricular injection of amyloid β protein. estrogen receptor β lentiviral particles delivered via intraventricular injection increased Akt content in the hippocampus, decreased interleukin-1β mRNA tumor necrosis factor a mRNA and amyloid β protein levels in the hippocampus, and improved the learning and memory capacities in AIzheimer＇s disease rats. estrogen receptor β short hairpin RNA lentiviral particles delivered via intraventricular injection had none of the above impacts on AIzheimer＇s disease rats. These experimental findings indicate that estrogen receptor β, independent from estrogen, can reduce inflammatory reactions and amyloid β deposition in the hJppocampus of AIzheimer＇s disease rats, and improve learning and memory capacities. This effect may be mediated through activation of the Akt pathway.

关键词： neural regeneration neurodegenerative diseases estrogen estrogen receptor β Alzheimer's disease amyloid β protein inflammatory cytokines Akt signaling pathway cognition neural protection photographs-containing paper neuroregeneration

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estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis

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World Journal of Gastroenterology 2017年第37期23卷 6802-6816页

作者： Janaki K Iyer Mamta Kalra Anil Kaul Mark E Payton Rashmi Kaul Department of Biochemistry and Microbiology Oklahoma State University-Center for Health Sciences Department of Natural Sciences Northeastern State University Immatics US Inc Health Care Administration Oklahoma State University-Center for Health Sciences Department of Statistics Oklahoma State University

AIM To investigate gender-specific liver estrogen receptor(ER) expression in normal subjects and patients with hepatitis C virus(HCV)-related cirrhosis and hepatocellular carcinoma(HCC).METHODS Liver tissues from normal donors and patients diagnosed with HCV-related cirrhosis and HCV-related HCC were obtained from the NIH Liver Tissue and Cell Distribution System. The expression of ER subtypes, ERα and ERβ, were evaluated by Western blotting and real-time RT-PCR. The subcellular distribution of ERα and ERβ was further determined in nuclear and cytoplasmic tissue lysates along with the expression ofinflammatory [activated NF-κB and IκB-kinase(IKK)] and oncogenic(cyclin D1) markers by Western blotting and immunohistochemistry. The expression of ERα and ERβ was correlated with the expression of activated NF-κB, activated IKK and cyclin D1 by Spearman's correlation. RESULTS Both ER subtypes were expressed in normal livers but male livers showed significantly higher expression of ERα than females(P < 0.05). We observed significantly higher m RNA expression of ERα in HCV-related HCC liver tissues as compared to normals(P < 0.05) and ERβ in livers of HCV-related cirrhosis and HCV-related HCC subjects(P < 0.05). At the protein level, there was a significantly higher expression of nuclear ERα in livers of HCV-related HCC patients and nuclear ERβ in HCV-related cirrhosis patients as compared to normals(P < 0.05). Furthermore, we observed a significantly higher expression of phosphorylated NF-κB and cyclin D1 in diseased livers(P < 0.05). There was a positive correlation between the expression of nuclear ER subtypes and nuclear cyclin D1 and a negative correlation between cytoplasmic ER subtypes and cytoplasmic phosphorylated IKK in HCV-related HCC livers. These findings suggest that dysregulated expression of ER subtypes following chronic HCVinfection may contribute to the progression of HCVrelated cirrhosis to HCV-related *** Gender differences were observed in ER

关键词： estrogen receptor α estrogen receptor β Hepatitis C virus-related cirrhosis Hepatitis C virusrelated hepatocellular carcinoma Sex and gender Normal liver

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Expressions of estrogen receptor subtypes and c-met proto-oncogene in endometrial carcinoma and their correlation

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Journal of Pharmaceutical Analysis 2010年第1期22卷 54-58页

作者： Yue-Ling Wang,Wei-Dong Dai,Jiang-Fen Wang,Lin Liu Department of Obstetrics and Gynecology,the First Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710061,China Department of Obstetrics and Gynecology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China

Objective To investigate the expressions of estrogen receptor(ER)subtypes and c-met proto-oncogene in human endometrial carcinomas and to assess the clinical significance of ER and c-met in this *** Reverse transcription PCR(RT-PCR)was used to detect the expressions of ERα,ERβ and c-met proto-oncogene mRNA in 30 samples of endometrial carcinoma and 11 samples of normal *** The expression of ERα in endometrial carcinoma(0.70±0.40)was significantly reduced in comparison to that in normal endometrium(1.14±0.56,P<0.05).A similar finding was made for the expression of ERβ in carcinoma(0.24±0.18)versus normal tissues(0.48±0.20,P<0.05).In contrast,c-met mRNA expression was increased in endometrial carcinoma(1.45±0.72)compared to that in normal endometrium(0.42±0.31,P<0.01).A decrease tendency of the expression of ERα was also found from Stage Ⅰ(0.82±0.41)to a more severe Stag Ⅱ-Ⅲ of endometrial carcinoma(0.42±0.17,P<0.05).The analysis of ERα and ERβ mRNA revealed a decrease tendency from shallow to deep invasion of the uterine muscles(P<0.05).We found that the expressions of ERα and ERβ were negatively correlated with c-met proto-oncogene with a coefficient correlation of-0.63(P<0.01)and-0.32(P<0.05),*** ERα and ERβ are both involved in mutagenic action of carcinogen.C-met proto-oncogene plays an important role in the carcinogenesis and development of endometrial carcinoma.C-met and ER expressions show a negative correlation in the development of endometrial carcinoma.

关键词： estrogen receptor α estrogen receptor β c-met proto-oncogene endometrial carcinoma

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Inhibitory effect of estrogen receptor beta on P2X7 receptors in inflammatory bowel disease(IBD) in rats

Inhibitory effect of estrogen receptor beta on P2X7 receptor...

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中国生理学会消化与营养专业委员会成立大会暨第一届学术会议

作者： Wen-xin Li Qian Jiang 马蓓 Department of Physiology Second Military Medical University Experimental training center for Basic Medical Sciences 中国人民解放军第二军医大学中国人民解放军第二军医大学基础医学实验教学中心

Objective estrogen receptor beta(ERβ)and P2X7 receptors(P2X7R)have been shown to play therapeutic roles in inflammatory bowel disease(IBD).However the mechanisms underlying how ERβexerts therapeutic effects and its relationship with P2X7R in rats with inflammation are not *** present study is to investigate the role and the underlying mechanisms of ERβactivation in the treatment of chronic inflammation including IBD and its relationship with ***:In our study animal behavior tests immunofluorescence technique western blotting ELISA and lentiviral transfection were used to determine the therapeutic effect of ERβin rats and the underlying mechanisms of its relation with ***:(1)ERβ receptors and P2X7 receptors were co-expressed in both RAW264.7 macrophages and the isolated macrophages of colorectum in rats.(2)Activation of P2X7 receptors significantly promoted the initiation and development of the colonic inflammation including the more weight loss increased DAI scores and the release of IL-1β.(3)ERβ but not ERαagonists significantly inhibited the initiation and development of colonic inflammation.(4)Activation of ERβ significantly inhibited the expression and function of P2X7 receptors in colorectum in IBD rats.(5)The JAK2-STAT3 signaling pathway was involved in both the therapeutic role of ERβ activation in the colonic inflammation and the inhibitory role of P2X7R expression and ***:These results suggest that ERβ activation plays an important therapeutic role in colonic inflammation through down-regulation of P2X7R in colorectum probably via JAk2-STAT3 signaling pathway which might provide a novel therapeutic strategy for clinical treatment of IBD.

关键词： estrogen receptor β P2X7 receptors Inflammatory bowel disease Microphage IL-1β

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Inhibitory effect of estrogen receptor beta on P2X3 receptors during inflammation in rats

Inhibitory effect of estrogen receptor beta on P2X3 receptor...

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中国生理学会消化与营养专业委员会成立大会暨第一届学术会议

作者： Wen-xin Li Qian Jiang Juan Fan 马蓓 Department of Physiology Second Military Medical University Experimental training center for Basic Medical Sciences 中国人民解放军第二军医大学中国人民解放军第二军医大学基础医学实验教学中心

Objective It has been reported that estrogen receptor beta(ERβ)might play a therapeutic role in inflammatory bowel disease(IBD),while the underlying mechanism is not known.P2X3 receptors are widely accepted to be closely related to *** present study is to investigate the role and the underlying mechanisms of ERβactivation in the treatment of chronic inflammation including IBD and its relationship with ***:In our study animal behavior tests visceromotor reflex recording and western blotting were used to determine whether the therapeutic effect of ERβin rats with inflammation was related with ***:In complete Freund adjuvant(CFA)-induced chronic inflammation in rats paw withdrawal threshold was significantly decreased which were then reversed by systemic injection of ERβagonists DPN or *** 246-trinitrobenzene sulfonic acid(TNBS)-induced colitis in rats weight loss higher DAI scores increased visceromotor responses and inflammatory responses were reversed by application of DPN or *** higher expressions of P2X3R in dorsal root ganglia(DRG)of CFA-treated rats and those in colorectum and DRG of TNBS-treated rats were all decreased by injection of DPN or *** hyperalgesia and increased P2X3 expression in ovariectomized(OVX)CFA-treated rats were reversed by estrogen *** the expressions of extracellular signal-regulated kinase(ERK)in DRG and spinal cord dorsal horn(SCDH)and c-fos in SCDH were significantly decreased after estrogen replacement compared with those of OVX *** ERK antagonist U0126 significantly reversed mechanical hyperalgesia in the OVX ***:These results suggest that estrogen may play an important therapeutic role in inflammation through down-regulation of P2X3R in peripheral tissues and the nervous system probably via ERβsuggesting a novel therapeutic strategy for clinical treatment of inflammation.

关键词： estrogen receptor β P2X3 receptor CFA TNBS Inflammation

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Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review

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Cancer Biology & Medicine 2016年第3期13卷 399-403页

作者： Da-Lin Gao Qian-Qian Fu Tian-Tian Zhang Lin Sun Yi Pan Qiong-Li Zhai Department of Pathology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin Key Laboratory of Cancer Prevention and Therapy

Lymphoma rarely occurs during pregnancy, making this condition difficult to define. Lymphomas that occur in reproductive organs during pregnancy exhibit unique clinical characteristics. Among the limited cases, non-Hodgkin's lymphoma(NHL) shows a considerably higher incidence rate than Hodgkin's lymphoma(HL); NHL also displays clinical characteristics, such as high aggressiveness, advanced stage, and poor outcome. This study reports on four cases of lymphomas in non-gonadal organs(HL,n=2; NHL, n=2) during pregnancy. The tumors rapidly progressed in all patients during pregnancy but remitted at the end of pregnancy and/or therapy. The two HL cases were nodular sclerosis classical HL and treated with chemotherapy after terminating the pregnancy. One of the NHL cases was primary cutaneous follicular center lymphoma, a B cell-derived indolent *** patient was followed up without any therapy after terminating her pregnancy. The other case was a follicular lymphoma grade3 B, which was treated with chemotherapy after delivery. We also conducted a literature review of 165 lymphoma cases occurring during pregnancy reported from 1976 to 2013 to reveal the correlation between pregnancy and lymphoma *** studies were performed to determine the expression of estrogen/progesterone receptors(ER/PR), and ER was weakly positive and sporadic. We concluded that lymphomas occurring during pregnancy should be managed with a prompt and reasonable treatment. High estrogen level in maternal body may affect lymphoma progression.

关键词： Lymphoma pregnancy estrogen estrogen receptor β BCL2

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