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Estimating the prevalence of schistosomiasis japonica in China:a serological approach

Infectious Diseases of Poverty 2018年第1期7卷 601-610页

作者： Xin-Yao Wang Jing Xu Song Zhao Wei Li Jian-Feng Zhang Jian He Ashley M.Swing Kun Yang Jiangsu Institute of Parasitic Diseases Yangxiang117#MeiyuanWuxi 214064JiangsuChina Key Laboratory on Technology for Parasitic Disease Prevention and Control Ministry of HealthJiangsu Provincial Key Laboratory on the Molecular Biology of ParasitesYangxiang117#MeiyuanWuxi 214064JiangsuChina Public Health Research Center Jiangnan UniversityJiangsuShengChina National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghaiChina

Background:The prevalence of schistosomiasis japonica has decreased significantly,and the responses changing from control to elimination in Jiangsu Province,*** to estimate the change in prevalence of schistosomiasis using only serological data will be important and ***:We collected serum samples from 2011 to 2015 to build a serum bank from Dantu County of Jiangsu,*** samples were detected by enzyme-linked immunosorbent assay(ELISA),the positive rate and optical density(OD)value were *** Bayesian model including the prior information of sensitivity and specificity of ELISA was established,and the estimated infection rates were obtained for different years,genders and age ***:There was no significant difference in the mean OD between different years and genders,but there was a significant difference between the different age *** were statistically significant differences in the positive rate for different years and age groups,but no significant difference at different *** estimated infection rate for the five years was 1.288,1.456,1.032,1.485 and 1.358%,*** was no significant difference between different years and between genders,but a significant difference between different age ***:The risk of schistosomiasis transmission in this area still exists,and risk monitoring of schistosomiasis should be strengthened.

关键词： Enzyme-linked immunosorbent assay(ELISA) Bayesian statistics Schistosomiasis japonica Sensitivity Specificity estimated infection rate

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