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The Therapeutic Effects of Rehmannia Oral Liquid for the Syndrome of Heat Accumulation with Yin Consumption in esophagus cancer Patients Undergoing Radiotherapy——A Report of 60 Cases

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Journal of Traditional Chinese Medicine 2007年第4期27卷 248-254页

作者：郑玉玲王新中 Zhengzhou University

Objective: To observe the clinical therapeutic effects of Rehmannia Oral Liquid on the syndrome of heat accumulation with Yin consumption in intermediate or late esophagus cancer patients undergoing radiotherapy. Methods: The IFN-α, TNF-α, IL-1β and TGF-β1 levels in sera were determined by the method of ABC-WLISA before and after the treatment with Rehmannia Oral Liquid. At the same time, the observation was carried out on the patient's general condition, symptoms and signs, barium meal or CT examinations, and biopsy. Another 30 cases of esophagus cancer were treated singly with radiotherapy as the control group. Results: Rehmannia Oral Liquid could obviously improve the patient's general condition, and the symptoms and signs after radiotherapy. Based on the X-ray examination and biopsy, the short-term local control rate of the treatment group and the control group was 70.0% and 40.0% respectively, showing a significant difference (Pcancer groups was lower and the levels of TNF-α, IL-1β and TGF-β1 were higher than that of normal group. After treatment, the level of IFN-α in both treatment group and control group increased significantly (P0.05) after treatment. The difference between groups was significant (P<0.05). Conclusion: Rehmannia Oral Liquid can obviously reduce the radiotherapy reaction, improve the quality of life, and raise the therapeutic effects. The action mechanism of the Liquid may lie in balancing the cytokine network and regulating the disordered signal t

关键词： esophagus cancer Rehmannia Oral Liquid Cytokine

Prognostic Role of Tumor-Infiltrating Lymphocytes in esophagus cancer:a Meta-Analysis

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Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophag...

第十二届全国免疫学学术大会

作者： Zheng Xiao Song Xing Shao Yingjie Xu Bin Hu Wenwei Zhou Qi Chen Lujun Zhang Dachuan Wu Changping Jiang Jingting Department of Tumor Biological Treatment The Third Affiliated Hospital of Soochow University Jiangsu Engineering Research Center for Tumor Immunotherapy Institute of Cell Therapy Soochow University Department of Radiation Oncology The Third Affiliated Hospital of Soochow University Department of Oncology The Third Affiliated Hospital of Soochow University Department of Pathology The Third Affiliated Hospital of Soochow University

Background:The prognostic value of tumor-infiltrating lymphocytes(TILs) in patients with esophagus cancer is still *** performed a meta-analysis to evaluate the prognostic value of TILs in esophagus *** and Methods:We searched PubMed,Embase and the Cochrane Library(last update by March 20,2017) to identify studies assessing the effect of TILs on survival of patients with esophagus *** hazard ratios(HRs) for overall survival(OS) and disease-free survival(DFS) were estimated using fixed-effects models or random-effects models,which depends on the ***:Data from 21 observational studies and 2121 patients were *** analysis indicated that generalized TILs in intratumor were favorable prognostic markers for OS(pooled HR = 0.48;95%CI = 0.38-0.61;P 0.05).Conclusions:This meta-analysis suggests that some TIL subsets could serve as prognostic biomarker for patients with esophagus ***-quality randomized controlled trials are needed to determine whether these TILs could serve as targets for immunotherapy in esophagus cancer.

关键词： TILs Prognosis esophagus cancer Biomarker Meta-analysis

Correlation between the proportion of Tscm and prognosis in esophagus cancer

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Correlation between the proportion of Tscm and prognosis in ...

第十一届全国免疫学学术大会

作者： Zhang Chaoqi Zhang Zhen Huang Lan Zhang Yi Biotherapy Center the First Affiliated Hospital of Zhengzhou University Department of Oncology the First Affiliated Hospital of Zhengzhou University School of Life Sciences Zhengzhou University

Background: Memory T cell plays a critical role in the inhibition of tumor growth and development. The memory T cell can be divided into 3 subsets: T memory stem cell(Tscm), central memory T cell(Tcm) and effector memory T cell(Tem). The anti-tumor ability of scm is superior to the Tcm and Tem. However, there is few reports about the correlationbetween the percentage of Tscm and the prognosis of patients with esophagus cancer. Aims: To detect the proportion of Tscm in the peripheral blood mononuclear cell(PBMC) and the paired tumor infiltrating lymphocytes(TIL) of patients. The relationship between Tscm and the prognosis of patients will be analyzed. Methods: The paired peripheral blood and tumor tissues of 65 esophagus cancer patients were collected from March to August 2013. PBMC from patients with cancer were isolated by Ficoll-Hypaque density gradient centrifugation. The tumor tissues were cut into small pieces and dipped into collagenase IV. Then the TIL were obtained. The percentage of CD3CD8 CD45RA CCR7 CD95(Tscm), CD3 CD8CD45RA- CCR7(Tcm) and CD3 CD8CD45RA- CCR7-(Tem) in the PBMC and TIL were detected by flow cytometry. Meanwhile, the relationship between the proportion of Tscm and the prognosis of patients were ***: The proportions of Tscm were form 7.4% to 31.1% in the PBMC and 10.2% to 48.8% in the TIL. Progression Free Survival(PFS) analysis indicate that the 21 patients in the high percentage of Tscm group(PBMC>15%,TIL>20%), compared with the 15 patients in the low percentage of Tscm group(PBMCesophagus cancer, which may act as an indicator for the prognosis of patients with esophagus cancer.

关键词： esophagus cancer prognosis T memory stem cell peripheral blood tumor infiltrating lymphocytes

Gene function analysis and underlying mechanism of esophagus cancer based on microarray gene expression profiling

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Gene function analysis and underlying mechanism of esophagus...

第十二届全国免疫学学术大会

作者： Song Mengjia Qiao Yamin Li Feng Zhang Yi Biotherapy Center the First Affiliated Hospital of Zhengzhou University cancer Center the First Affiliated Hospital of Zhengzhou University School of Life Sciences Zhengzhou University

Purpose:Esophageal cancer(EC) is one of the most common digestive malignant tumors *** the past decades,there have been minimal improvements in outcomes for patients with *** targets and novel therapies are needed to improve outcomes for these *** study aimed to explore the molecular mechanisms of EC by integrated bioinformatic analyses of the feature genes associated with EC and correlative gene functions which can distinguish cancerous tissues from non-cancerous ***:Gene expression profile GSE20347 was downloaded from Gene Expression Omnibus(GEO) database,including 17 EC samples and their paired adjacent non-cancerous *** differentially expressed genes(DEGs) between EC and normal specimens were identified and then applied to analyze the GO enrichment on gene functions and KEGG *** Pathway Relation Network(Pathway-net) and Gene Signal Network(signal-net) of DEGs were established based on the data collected from GCBI *** database and our clinical samples of EC were used to analyze the expression of DEGs and their correlation to the prognosis for patients with ***:The results showed that DEGs mainly participated in the process of cell adhesion,cell proliferation,survival,invasion,metastasis and *** expression of PTK2,MAPK signaling pathway,PI3 K-Akt signaling pathway,p53 signaling pathway and MET were closely associated with EC ***,Interleukin 8(IL8) and C-X-C chemokine receptor type 7(CXCR-7) were predicted to be significantly related to *** findings were further validated by analyzing both TCGA database and our clinical samples of ***:Our discovery provides a registry of genes and pathways that are disrupted in EC,which has the potential to be used in clinic for diagnosis and target therapy of EC in future.

关键词： esophagus cancer gene function analysis microarray gene expression

Prognostic Role of Tumor-Infiltrating Lymphocytes in esophagus cancer: a Meta-Analysis

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Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophag...

第十三届全国免疫学学术大会

作者： Xiao Zheng Xing Song Yingjie Shao Jingting Jiang Department of Tumor Biological Treatment The Third Affiliated Hospital of Soochow University Jiangsu Engineering Research Center for Tumor Immunotherapy Institute of Cell Therapy Soochow University

Background: The prognostic value of tumor-infiltrating lymphocytes(TILs) in patients with esophagus cancer is still *** performed a meta-analysis to evaluate the prognostic value of TILs in esophagus *** and Methods: We searched PubMed, Embase and the Cochrane Library(last update by March 20, 2017) to identify studies assessing the effect of TILs on survival of patients with esophagus *** hazard ratios(HRs) for overall survival(OS) and disease-free survival(DFS) were estimated using fixed-effects models or random-effects models, which depends on the ***: Data from 21 observational studies and 2121 patients were *** analysis indicated that generalized TILs in intratumor were favorable prognostic markers for OS(pooled HR = 0.48;95% CI = 0.38-0.61;P0.05).Conclusions: This meta-analysis suggests that some TIL subsets could serve as prognostic biomarker for patients with esophagus ***-quality randomized controlled trials areneeded to determine whetherthese TILs could serve as targets for immunotherapy in esophagus cancer.

关键词： TILs Prognosis esophagus cancer Biomarker Meta-analysis

Induction chemotherapy with albumin-bound paclitaxel plus lobaplatin followed by concurrent radiochemotherapy for locally advanced esophageal cancer

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1781-1790页

作者： Mao-Hui Yan Fang Liu Bao-Lin Qu Bo-Ning Cai Wei Yu Xiang-Kun Dai Department of Radiotherapy The First Medical Center of the Chinese People's Liberation Army(PLA)General HospitalBeijing 100853China

BACKGROUND Albumin-bound paclitaxel(ABP)has been used as second-and higher-line treatments for advanced esophageal cancer,and its efficacy and safety have been well ***(LBP)is a third-generation platinum antitumor agent;compared with the first two generations of platinum agents,it has lower toxicity and has been approved for the treatment of breast cancer,small cell lung cancer,and chronic granulocytic ***,its role in the treatment of esophageal cancer warrants further *** To investigate the efficacy and safety of induction chemotherapy with ABP plus LBP followed by concurrent radiochemotherapy(RCT)for locally advanced esophageal *** Patients with pathologically confirmed advanced esophageal squamous cell carcinoma(ESCC)at our hospital were enrolled in this *** patients were treated with two cycles of induction chemotherapy with ABP plus LBP followed by concurrent RCT:ABP 250 mg/m^(2),ivgtt,30 min,d1,every 3 wk;and LBP,30 mg/m^(2),ivgtt,2 h,d1,every 3 wk.A total of four cycles were *** dose of the concurrent radiotherapy was 56-60 Gy/28-30 fractions,1.8-2.0 Gy/fraction,and 5 fractions/*** A total of 29 patients were included,and 26 of them completed the treatment *** the induction chemotherapy,the objective response rate(ORR)was 61.54%,the disease control rate(DCR)was 88.46%,and the progressive disease(PD)rate was 11.54%;after the concurrent RCT,the ORR was 76.92%,the DCR was 88.46%,and the PD rate was 11.54%.The median progression-free survival was 11.1 mo and the median overall survival was 15.83 *** multivariate analysis revealed that two cycles of induction chemotherapy followed by concurrent RCT significantly reduced the risk of PD compared with two cycles of chemotherapy alone(P=0.0024).Non-hematologic toxicities were tolerable,and the only grade 3 non-hematologic toxicity was radiation-induced esophagitis(13.79%).The main hematologic toxicity was neutropenia,and no

关键词： Esophageal squamous cell carcinoma esophagus cancer Induction chemotherapy Concurrent radiochemotherapy Radiotherapy Chemotherapy Albuminbound paclitaxel Lobaplatin

Is endoscopic ultrasound examination necessary in the management of esophageal cancer?

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World Journal of Gastroenterology 2017年第5期23卷 751-762页

作者： Tomas DaVee Jaffer A Ajani Jeffrey H Lee Department of Gastroenterology Hepatology and NutritionDivision of Internal MedicineThe University of Texas MD Anderson Cancer Center Department of Gastrointestinal Medical Oncology Division of Cancer MedicineThe University of Texas MD Anderson Cancer Center

Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer(EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970 s, the result of advances in diagnostic staging and treatment. As the most sensitive test for locoregional staging of EC, endoscopic ultrasound(EUS) influences the development of an optimal oncologic treatment plan for a significant minority of patients with early cancers, which appropriately balances the risks and benefits of surgery, chemotherapy and radiation. EUS is costly, and may not be available at all centers. Thus, the yield of EUS needs to be thoughtfully considered for each patient. Localized intramucosal cancers occasionally require endoscopic resection(ER) for histologic staging or treatment; EUS evaluation may detect suspicious lymph nodes prior to exposing the patient to the risks of ER. Although positron emission tomography(PET) has been increasingly utilized in staging EC, it may be unnecessary for clinical staging of early, localized EC and carries the risk of false-positive metastasis(over staging). In EC patients with evidence of advanced disease, EUS or PET may be used to define the radiotherapy field. Multimodality staging with EUS, crosssectional imaging and histopathologic analysis of ER, remains the standard-of-care in the evaluation of early esophageal cancers. Herein, published data regarding use of EUS for intramucosal, local, regional and metastatic esophageal cancers are reviewed. An algorithm to illustrate the current use of EUS at The University of Texas MD Anderson cancer Center is presented.

关键词： Esophageal squamous cell carcinoma Endosonography Echoendoscope esophagus cancer Esophageal adenocarcinoma

Clinical Research Regarding the Ratio of Lymph Node Metastasis and the Reasonable Extent of Lymphadenectomy in Middle Third Thoracic Esophageal Squamous Cell Carcinoma

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Clinical oncology and cancer researeh 2010年第1期7卷 33-38页

作者： Ming-ran XIE Peng LIN Xu ZHANG Jie-xin CHEN Yong-bin LIN Zhe-sheng WEN Tie-hua RONG Xiao-dong LI Jun-ye WANG Hui YU State Key Laboratory of Oncology in SouthChina Department of Thoracic OncologyCancer Center Sun Yat-sen UniversityGuangzhou 510060 Guangdong ProvinceChina.

OBJECTIVE To explore the extent of lymphadenectomy deemed reasonable by analyzing the influence of the regular pattern and ratio of lymph node metastasis on the prognosis of the patients with middle third thoracic esophageal squamous cell carcinoma. METHODS Clinical data from 129 patients with middle third thoracic esophageal squamous cell carcinoma who underwent curative esophagectomy with modem two-field lymphadenectomy were retrospectively analyzed. RESULTS The rate of lymphatic metastasis in EC patients was 56.6% in all groups, and the ratio of lymph node metastasis （RLNM, i.e. positive nodes/total dissected nodes） was 11.3%, with a lymphatic metastasis rate of 43.4% in the superior mediastinum. The most commonly involved regions included the sites around the esophagus, the right recurrent laryngeal nerve and the left- sided blood vessels of stomach, as well as the cardia and the inferior tracheal protuberance. The main factors influencing lymphatic metastasis were the depth of tumor infiltration, differentiation of tumor cells and the size of the tumor. The 5-year survival rate for patients in the groups without lymphatic metastasis, with a RLNM 〈 20%, and a metastasis ratio 〉 20% was 50.4%, 31.0% and 6.8%, respectively. The differences were statistically significant among the groups （P = 0.000）. CONCLUSION The RLNM is one of the key factors affecting the prognosis of EC patients. For conventional therapy for patients with middle third thoracic esophageal carcinoma, modern 2-field lymphadenectomy, including node dissection in the bilateral superior mediastinum, should be performed.

关键词： esophagus cancer lymph nodes metastasis lymphadenectomy.

Burden of six major types of digestive system cancers globally and in China

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Chinese Medical Journal 2024年第16期137卷 1957-1964页

作者： Yueyang Zhou Kai Song Yuqing Chen Yuelun Zhang Min Dai Dong Wu Hongda Chen Center for Prevention and Early Intervention National Infrastructures for Translational MedicineInstitute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology People’s Hospital of Xizang Autonomous RegionLhasaXizang autonomous region 85000China

Background:Digestive system cancers constitute a significant number of cancer cases,but their burden is not *** Global cancer Observatory(GLOBOCAN)2022 has recently updated its estimates of cancer burden,we aimed to investigate the burden of six major digestive system cancers both worldwide and in China,along with geographical and temporal variations in cancer-specific incidence and ***:We extracted data on primary cancers of the esophagus,stomach,colorectum,liver,pancreas,and gallbladder from the GLOBOCAN database for ***-standardized incidence and mortality rates were calculated and stratified by sex,country,region,and human development index(HDI).We used the 2022 revision of the World Population Prospects(United Nations)to obtain demographic data for various age groups in China from 1988 to 2012 and used the joinpoint model and the average annual percentage change(AAPC)to analyze cancer incidence trends in ***:In 2022,the estimated global incidence of digestive system cancers reached 4,905,882,with an estimated 3,324,774 cancer-related *** cancer was most prevalent in terms of incidence and *** was a significant correlation between the burden of gastrointestinal cancers and country *** 1988 to 2012,the incidence of esophageal,gastric,and liver cancers declined in China,whereas colorectal and pancreatic cancer incidences continued to *** 2050,colorectal and liver cancers are projected to remain the leading cancer types in China in terms of incidence and mortality,***:Digestive system cancers remain a significant public health challenge globally and in *** progress has been made in the prevention and control of some cancers,the burden of digestive system cancers *** implementation of tertiary prevention strategies must be intensified to reduce the incidence and mortality of digestive system cancers,mitigating their impact on public health.

关键词： Digestive system cancer Incidence Mortality GLOBOCAN 2022 China Global esophagus cancer Stomach cancer Colorectal cancer