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Clinical Studies of Postoperative Arterial Infusion Chemotherapy in Patients with Pathologic T_3 esophageal squamous carcinoma

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Chinese Journal of Clinical Oncology 2006年第3期3卷 176-180页

作者： Baodong Liu Zongjun Dong Xiuyi Zhi Qingsheng Xu Department of Thoracic Surgery Xuanwu Hospital of Capital University of Medical Sciences Beijing 100053China.

OBJECTIVE To evaluate how arterial infusion chemotherapy after radical surgery influences long-term surviva if patients with pathologic T3 （pT3） esophageal squamous carcinoma. METHODS We divided 190 patients with pathologic PT3 esophageal squamous carcinoma, confirmed by consecutive radical surgery, into an experimental group （surgery ＋ intra-arterial infusion, 56 T3N0M0 and 52 T3N1M0 cases）, and the remaining patients into a control group （surgery alone, 48 T3N0M0 and 34 T3N1M0 cases）. The experimental group was sub-grouped into 56 cases （26 T3N0M0 and 30 T3N1M0 cases） receiving 1 or 2 periods of chemotherapy, while 52 cases （30 T3N0M0 and 22 T3N0M0 cases） underwent 3 or more than 3 periods of chemotherapy. We used one to seven courses of selected arterial infusion chemotherapy of cisplatin （80 mg/m2 of body-surface area） and fluorouracil （800 mg/m2） with or without epirubicin at 3-4 weeks post operation. The interval between each period was 3-4 weeks. All cases were followed-up for more than 5 years. Survival rates were calculated by the Kaplan-Meier methods and survival differences between patients with and without selected arterial infusion chemotherapy were compared with the Log-rank test. Prognostic variables were entered into a Cox regression analysis model controlling for age, site, lymph node status, and treatment received. RESULTS The overall survival rates were not significantly different between the experimental group and the control group, but there was better survival for patients who received 3 or more than 3 courses of chemotherapy. Lymph node status （N） was an important factor in the prognosis. CONCLUSION Trans-catheter arterial infusion chemotherapy is a safe and effective method of therapy. Postoperative selective arterial infusion chemotherapy can improve the survival rate in patients with esophageal squamous carcinoma who were previously treated by radical surgery. However, this modality of therapy needs further investigation.

关键词： esophageal squamous carcinoma arterial infusion chemotherapy.

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A retrospective study of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing neutropenia during definitive concurrent chemoradiotherapy in patients with esophageal squamous carcinoma

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Radiation Medicine and Protection 2022年第2期3卷 81-85页

作者： Xin Dong Wei Deng Leilei Jiang Dan Yang Huiming Yu Dongming Li Anhui Shi Rong Yu Weihu Wang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Radiation OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:To compare the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)for preventive or delayed treatment in neutropenia,completion rate of concurrent chemoradiotherapy and hospitalization rate in patients with esophageal squamous carcinoma during definitive concurrent ***:A total of 70 patients with esophageal squamous carcinoma in Peking University Cancer Hospital from January 2019 to December 2020,who received PEG-rhG-CSF during concurrent chemoradiotherapy,were enrolled in this retrospective *** were 32 patients in the preventive group,and 38 patients in the delayed *** incidence of neutropenia,completion rate of concurrent chemoradiotherapy and neutropeniarelated hospitalization rate were compared between PEG-rhG-CSF preventive group and delayed ***:The incidence of severe neutropenia(Grades 3–4)in all patients was 31.4%.Comparison between preventive group and delayed group showed that the incidence of severe neutropenia was 6.3%and 39.4%(χ^(2)=10.428,P=0.001),*** preventive group,the incidence of severe neutropenia was 3.7%and 20.0%,respectively,for primary prevention and secondary prevention of PEG-rhG-CSF(χ^(2)=12.321,P=0.001).The completion rate of concurrent chemoradiotherapy was 93.8%in the preventive group and 63.2%in the delayed group(χ^(2)=9.220,P=0.002).The incidence of treatment interruption was 25.7%in the whole group,12.5%in the preventive group and 36.8%in the delayed group(χ^(2)=5.389,P=0.020).Seven patients(7/70,10.0%)were hospitalized and treated with intravenous antibiotics for neutropenia,including 1 in the preventive group and 6 in the delayed group(P=0.078).Conclusions:Prophylactic use of PEG-rhG-CSF during concurrent chemoradiotherapy for patients with esophageal squamous carcinoma can effectively reduce the incidence of neutropenia,ensure the safety of treatment,and improve the completion rate of concurrent chemoradiothe

关键词： esophageal squamous carcinoma Concurrent chemoradiotherapy Pegylated recombinant human granulocyte colony-stimulating factor

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