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Suppression of esophageal cancer cell growth using curcumin,(-)-epigallocatechin-3-gallate and lovastatin

World Journal of Gastroenterology 2012年第2期18卷 126-135页

作者： Fei Ye Gui-Hong Zhang Bao-Xiang Guan Xiao-Chun Xu Department of Clinical cancer Prevention The Universityof Texas MD Anderson Cancer Center Houston TX 77030United States Department of Pathology Anhui Medical University Hefei 230032 Anhui ProvinceChina

AIM:To determine the effects of curcumin,(-)-epigallocatechin-3-gallate (EGCG),lovastatin,and their combinations on inhibition of esophageal ***:esophageal cancer TE-8 and SKGT-4 cell lines were subjected to cell viability methyl thiazolyl tetrazolium and tumor cell invasion assays in vitro and tumor formation and growth in nude mouse xenografts with or without curcumin,EGCG and lovastatin *** expression was detected using immunohistochemistry and Western blotting in tumor cell lines,tumor xenografts and human esophageal cancer tissues,***:These drugs individually or in combinations significantly reduced the viability and invasion capacity of esophageal cancer cells in ***,these three agents reduced the expression of phosphorylated extracellular-signal-regulated kinases (Erk1/2),c-Jun and cyclooxygenase-2 (COX-2),but activated caspase 3 in esophageal cancer *** nude mouse xenograft assay showed that EGCG and the combinations of curcumin,EGCG and lovastatin suppressed esophageal cancer cell growth and reduced the expression of Ki67,phosphorylated Erk1/2 and *** expression of phosphorylated Erk1/2 and COX-2 in esophageal cancer tissue specimens was also analyzed using *** data demonstrated that 77 of 156 (49.4%) tumors expressed phosphorylated Erk1/2 and that 121 of 156 (77.6%) esophageal cancers expressed COX-2 *** particular,phosphorylated Erk1/2 was expressed in 23 of 50 (46%) cases of esophageal squamous cell carcinoma (SCC) and in 54 of 106 (50.9%) cases of adenocarcinoma,while COX-2 was expressed in 39 of 50 (78%) esophageal SCC and in 82 of 106 (77.4%) esophageal ***:The combinations of curcumin,EGCG and lovastatin were able to suppress esophageal cancer cell growth in vitro and in nude mouse xenografts,these drugs also inhibited phosphorylated Erk1/2,c-Jun and COX-2 expression.

关键词： Chemoprevention Curcumin Cyclooxygen-ase-2 (-)-epigallocatechin-3-gallate esophageal can-cer Statin

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