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The anti-tumor effect of erzhi pills on breast cancer cell MCF-7 and the intervention in endocrine therapy adverse reactions

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TMR Theory and Hypothesis 2019年第1期2卷 156-163页

作者： Qi Liu Long-Long Li Chun-Hong Xu Guang-Qiang Zhang Zheng Sun Ming-Ming Shi Shi-Min Ji Guo-Lou Li Depatment of Breast and Thyroid Surgry The Traditional Chinese Medicine Hospital of WeifangShandongChina Clinical College of Weifang Medical University ShandongChina Depatment of General Surgry The Traditional Chinese Medicine Hospital of ShouguangShandongChina

Objective:The aim of this study was to investigate the potential ability of medicated serum of erzhi pills on growth,proliferation and inflammation of the human breast cancer cell line MCF-7 ***:3-month-old female Sprague–Dawley rats were used to prepared medicated serum,and randomly assigned into four groups:control group(distillated water),low doses(2.25g/kg/d),middle doses(4.5g/kg/d),high does(9.0g/kg/d).The growth curve was meas-ured by MTT method,the proliferation was examined by colony formation ***-matory cytokines IL-1β,IL-18 and IL-6 was detected by Quantitative real time polymerase chain reaction(RT-qPCR).Western blot was used to examine the expression of NF-kB signal ***:The medicated serum of erzhi pills could inhibit the growth and proliferation of breast cancer cell MCF-7,especially,in the group of middle doses and high does(Perzhi pills played an anti-tumor role in breast cancer via inhibiting the growth and proliferation of ***,erzhi pills could suppress in-flammatory responses from the NFκB signaling pathways,and reduced skeletal muscle pain caused by breast cancer endocrine therapy,and erzhi pills may be a new target for the treatment of breast cancer.

关键词： Breast cancer erzhi pills Growth Proliferation Inflammation

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Clinical Analysis of erzhi Mingmu Decoction in the Treatment of Non-exudative Age-related Macular Degeneration

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World Journal of Integrated Traditional and Western Medicine 2018年第4期4卷 32-36页

作者： Jiang Yanhua Li Ruoxi Qi Fei Ophthalmology Department Shenyang Forth People's Hospital

OBJECTIVE: To study the effect of erzhi Mingmu Decoction in the treatment of non-exudative age-related macular degeneration. METHODS: A total of 100 patients with non-exudative age-related macular degeneration admitted to our hospital from May 2017 to May 2018 were selected. They were randomly divided into the study group and the control group. The control group was treated with oral vitamin C and vitamin E while study group was treated with erzhi Mingmu Decoction based on the same treatment of the control group. Both groups were continuously treated for 1 month, the visual improvement, fundus changes, and changes of serum VEGF and CRP levels were compared before and after treatment. RESULTS: The number of patients with visual improvement was higher in the study group than that in the control group(P erzhimingmu Decoction can significantly improve the vision of patients, improve the condition of the fundus, and reduce the levels of serum VEGF and CRP, which is worthy of clinical promotion and application.

关键词： Non-exudative age-associated macular degeneration erzhi Mingmu Decoction Vision Vascular endothelial growth factor C-reactive protein

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