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The Relationships between erythrocyte membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults:An Observational Study

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Biomedical and Environmental Sciences 2011年第3期24卷 234-242页

作者： ZHANG Bo WANG Ping ZHOU Quan CHEN ChaoGang ZHUO ShuYu YE YanBin HE QiQiang CHEN YuMing SU YiXiang Faculty of Nutrition School of Public Health Sun Yat-Sen University Guangzhou 510080 Guangdong China Department of Clinical Nutrition Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 Guangdong China Department of Clinical Nutrition the First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080 Guangdong China Faculty of Statistics and Epidemiology School of Public Health Sun Yat-Sen University Guangzhou 510080 Guangdong China

Objective To investigate the relationships between erythrocyte membrane n-6：n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein （hs-CRP）. Methods The Chinese and a observational study consisted of a population-based cross-sectiona subsequent 1-year follow-up study of 171 subjects with the fasting cholesterol of 5.13-8.00 mmol/L. study of 456 plasma total Results In the cross-sectional analysis, plasma low-density lipoprotein cholesterol （LDL-c） had a significant and negative association with the erythrocyte membrane n-6：n-3 PUFAs ratio （P for trend=0.019） after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6：n-3 ratio in erythrocyte membrane （△=month 12-month 0）. In the top quartile whose ratios of n-6：n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6：n-3 decreased by an average of 1.13 （-1.07 mmol/L v.s. -0.32 mmol/L）. The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile （P for difference=0.052）. Conclusion Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.

关键词： erythrocyte membrane n-6:n-3 fatty acids ratio Blood lipids High sensitivity C-reactiveprotein Observational study

erythrocyte membrane encapsulated gambogic acid nanoparticles as a therapeutic for hepatocellular carcinoma

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Chinese Chemical Letters 2023年第1期34卷 251-254页

作者： Ruijie Liu Li He Maoyu Liu Lu Chen Jun Hou Jianyou Shi Lan Bai Affiliated Hospital of Southwest Jiaotong University/Department of Cardiology Chengdu Third People’s HospitalChengdu 610031China Department of Pharmacy Jianyang Chinese Medicine HospitalChengdu 641499China Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Gambogic acid(GA)is a potential clinical anticancer drug that can exert antitumor effects via various molecular ***,GA’s low water solubility,poor stability,short half-life,and unavoidable toxic side effects have significantly hampered its clinical *** membranecoated nanoparticles(RBCM-NPs)improve drug’s physicochemical properties,biocompatibility,and pharmacokinetic behaviors,allowing for long-term drug circulation and passive *** this study,a novel biomimetic drug delivery system(DDS)against hepatocellular carcinoma was prepared by covering RBCM on GPP-NPs(GA-loaded m PEG-PLA NPs)to develop the RBC@*** comparison to RBCM-free nanoparticles and free GA,RBC@GPP-NPs improved the drug’s water solubility,stability,safety,and antitumor activity in *** expect that this bionic nanoparticle composite can expand the clinical applicability of GA and provide a feasible solution for the research and development of GA’s nano-formulation.

关键词： Gambogic acid erythrocyte membrane Drug delivery systems Biomimetic nanoparticles Hepatocellular carcinoma

Effect of Huoxuequyu Recipe on erythrocyte membrane Ca^(2+)-ATPase Activity in Pregnant Rats with Asymmetrical Intrauterine Growth Retardation Induced by Passive Smoking

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1995年第1期15卷 35-37页

作者：陈琢舒沪英 Department of Traditional Chinese Medicine Tongji Hospital Tongji Medical University Wuhan

The effect of Huoxuequyu recipe on erythrocyte membrane Ca2+-ATPase activity in pregnant rats with passive smoking induced asymmetrical intrauterine growth retardation(IUGR)was *** rats were divided into three groups:control group,model group and treated *** fetal mean birth weight and erythrocyte membrane Ca2+-ATPase activity were found to be decreased in the model group as compared with the control and treated *** was a significant difference between the model group and the control group(P0.05).Furthermore,the findings indicated that the erythrocyte membrane Ca2+-ATPase activity seem to be positively correlated with the birth weight(Perythrocyte membrane Ca2+-ATPase activity and promote blood circulation, thereby exerting a beneficial effect on fetal development.

关键词： smoking erythrocyte membrane Ca2+-ATPase Huoxuequyu recipe IUGR

Effect of "Jia Wei Fo Shou San" on erythrocyte membrane Calcium,Zinc Concentration in Pregnant Rats with Asymmetrical Intrauterine Growth Retardation Induced by Passive Smoking

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1997年第4期17卷 218-220页

作者：陈琢吴汉卿张裕曾舒沪英 Department of Traditional Chinese Medicine Tongji Hospital Tongji Medical University Wuhan

Using experimental model of pregnant rats with asymmetrical intrauterine fetal growth retardation induced by passive smoking, the effects of natural herb 'Jia Wei Fo Shou San' on erythrocyte membrane calcium, zinc concentration were observed by atomic absorption spectrophotometry. The results showed that the mean fetal birth weight, zinc concentration of erythrocyte membrane were found to be decreased in the model group as compared with the control group (P＜0. 01, P＜0. 01). On the other hand, the element of calcium onto erythrocyte membrane were higher in model group than that in control group(P＜0. 05). These changes were significantly mild in the treated group and were similar to those of the control group (P＜0.05). Furthermore,our findings indicated that the zinc concentration of erythrocyte membrane seems to be positively correlated with the birth weight(P＜0. 01). Calcium composition of red cell membrane showed a significant negative relation to the birth weight (P＜0.05). Our results provided an experimental evidence that normal concentrations of calcium and zinc onto erythrocyte play an important part in fetal growth. One of the mechanisms of 'Jia Wei Fo Shou San' in improving fetal growth may have something to do with modulation of erythrocyte calcium,zinc element,thereby protecting bio-functions of erythrocyte and promoting blood circulation.

关键词： erythrocyte membrane calcium zinc IUGR passive smoking Huoxuequyu

Study on Phospholipid Composition of erythrocyte membrane in Hypophosphatemic Cows

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Agricultural Sciences in China 2002年第3期1卷 328-332页

作者： SHI Fa-qing, XUAN Da-wei, XU Shi-Wen and WANG Zhen-yong(The College of Animal Medicine , Northeast Agricultural University, Harbin 150030) The College of Animal Medicine Northeast Agricultural University Harbin 150030

The phospholipid constituents of the erythrocyte membrane of cows in hypophosophorus were detected with the field cases and the group comparison. The cows were divided into three groups: the hemoglobinuria group (HN), the hypophosphatemia group (HP) and the control group (CK). The content of the phospholipid constituent in HN and HP obviously changed: phosphatidylethaanolamine (PE) content in HN was significantly lower than that in HP and CK; but sphingomyline (SM) and phosphatidycholine (PC) + phosphatidylserine (PS) content in HN were significantly higher than that in the two other groups; in comparison between HP and CK, PC + PS content was lower and SM content was higher in HP; significant positive correlation and negative correlation were observed between serum phosphorus and PE content, serum phosphorus and SM content respectively.

关键词： Cows Phosphorus Phospholipid composition erythrocyte membrane

The Molecular Mechanism in the Damage of erythrocyte membrane of the Cows with Hemoglobinuria

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Journal of Northeast Agricultural University(English Edition) 2002年第2期9卷 117-127页

作者： SHIFa－qing LILing NortheastAgriculturalUniversity HarbinHeilongjiang150030PRC ChinaAgriculturalUniversity Beijing100094PRC

The molecular mechanism in the damage of erythrocyte membrane of the cows with hemoglobinuria was studied with the field cases and the group *** field cases were devided into three groups:the hemoglobinuria group(HG),the low phosphorous group(LPG)and the control group(CG).The content of phospholipid constituents in the erythrocyte membrane and the protein constituents in membrane skeleton were determined molecularly and the shape of erythrocyte was examined with the scanning electron *** result showed that:(1)the concentration of phosphatidylethanolamine(PE)in HG was lower significantly than that in LPG and CG;the concentration of sphingomyeline(SM) and phosphatidylcholine(PC)+phosphatidylserine(PS) in HG was significantly lower than that in the other groups;the content of PC+PS was lower and the concentration of SM was higher in LPG with comparing that in CG,the significant positive correlation was observed between the concentration of phosphorus in serum and the concentration of PE,*** significant negative correlation was observed between the content of phosphorus in serum and the content of SM,respectively.(2)the difference of protein constituent in membrane skeleton between LPG and CG was not found,however,the concentration of spectin in band Ⅰ,Ⅱ and the content of protein in band Ⅳ 2 was lower and the concentration of protein in band Ⅲ significantly higher in HG than that in LPG and CG(Perythrocyte observed with scanning electron microscope changed from discal to the spinal,to spheric form,to hemolysis ultimately following the reduction of the concentration of phosphorus in *** was concluded that the change of the constituent of phospholipid in erythrocyte membrane and protein in membrane skeleton and the form of erythrocyte is the most important factors in hemolysis for hypophosphatemia.

关键词： cows low phosphorus hemoglobinuria erythrocyte membrane

Experimental study of alternations in erythrocyte membrane lipid peroxidation and fluidity induced by high-cholesterol diet in rabbits

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South China Journal of Cardiology 2013年第4期14卷 262-265,285页

作者：马建林马立宁张家明张银环刘时武李斌陈关良苏哲坦万妮娜 Department of Cardiology Hainan People s Provincial Hospital Institute of Cardiovascular Disease Tongji Medical CollegeHuazhong University of Science and Technology

Background Animal models of hyperlipidemia were established by feeding rabbits with high-cholesterol diet, and the changes in structure and function of cell membrane in rabbits were also reduced by hyperlipidemia. Thus, the alternations in erythrocyte membrane lipid peroxidation （EMLP） and fluidity in rabbits induced by high-cholesterol diet were researched by us. Methods Fourteen rabbits were subjected to high-cholesterol diet （cholesterol 2 g/d） and the other 14 rabbits to common diet everyday for consecutive two months, plasma total cholesterol （TC）, and blood lipids as well as EMLP and fluidity were measured before and after the feeding. Results Compared with the feeding before, levels of TC and low density lipoprotein- cholesterol （LDL-C） were significantly raised, those of erythrocyte membrane low density lipoprotein- cholesterol （MLDL-C）, membrane conjugated diene （MCD）, erythrocyte malonaldehyde （RMDA） were significantly increased, while those of erythrocyte superoxide dismutase （R-SOD）, membrane fluidity （M-Flu） and membrane high density lipoprotein-cholesterol （MHDL-C） were significantly decreased in experimental group, and there were no changes in control group. Conclusions High-cholesterol diet induces lipid peroxidation and lower fluidity of erythrocyte membrane.

关键词： high-cholesterol diet erythrocyte membrane lipid peroxidation fluidity.

Effect　of　Huoxuequyu　Recipe　on　erythrocyte　Ultrastructure　and　membrane　ATPase　Activity　in　Rats　with　Passive　Smoking

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1996年第4期16卷 220-222页

作者：陈琢焦新福杨芙蓉吴汉清舒沪英 Department of Traditional Chinese Medicine Tongji Hospital Tongji Medical University Wuhan

The effect of 'Huoxuequyu' recipe on erythrocyte membrane Ca2+ATPase activity, Na+-K+-ATPase activity and erythrocyte ultrastructure in rats exposed to passive smoking were observed. The erythrocyte membrane Ca2+-ATPase activity and Na+-K+-ATPase activity were found to be decreased in the model group as compared with the control group (P0.05). Our results also showed that there were more deformed red blood cells in model group than in control group under TCM and SEM (P0.05). Furthermore,these findings indicated that 'Huoxuequyu' recipe , a prepared natural herbal medicine, may be involved in modulation of the activity of erythrocyte membrane enzymes,thereby protecting erythrocyte membrane, so as to improve the erythrocyte function.

关键词： smoking erythrocyte membrane ultrastructure Na+-K+-ATPase Ca￣(2+)-ATPase Huoxuequyu natural herbs

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锌缺乏对红细胞膜离子通道活性的影响

营养健康新观察 2002年第1期 10-14页

作者：韩军花杨月欣门建华王竹中国疾病预防控制中心营养与食品安全所中国疾病预防控制中心营养与食品安全所北京 100050

锌作为人体重要的必需微量元素,对维持细胞膜的结构和功能必不可少。离子转运是细胞膜的重要功能,研究认为,对维持红细胞膜两侧的离子平衡起重要作用的K~+、Na~+离子转运系统主要有Na~+/K~+泵、Na~+/K~+/Cl~-联合转运系统(COTS-1)、Gar... 详细信息

锌作为人体重要的必需微量元素,对维持细胞膜的结构和功能必不可少。离子转运是细胞膜的重要功能,研究认为,对维持红细胞膜两侧的离子平衡起重要作用的K~+、Na~+离子转运系统主要有Na~+/K~+泵、Na~+/K~+/Cl~-联合转运系统(COTS-1)、Gardos通道(Gardos channel)、K~+/Cl~-联合转运系统(COTS-2)以及残余渗漏(residual channel RF)等。目前国内外关于锌与细胞膜转运关系的研究,多限于锌

关键词： zinc erythrocyte membrane transport function