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基于工作模态辨识的高速飞行器运输约束动载荷辨识技术研究

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强度与环境 2024年第2期51卷 1-6页

作者：王亮张妍蔡毅鹏南宫自军中国运载火箭技术研究院北京100076

在运输振动测量数据基础上,本文提出了基于工作模态辨识的高速飞行器运输约束动载荷辨识方法。首先,详细介绍了era(Eigensystem Realization Algorithm)环境激励模态辨识方法的理论和载荷辨识时域方法的理论;其次,给出了飞行器结构动力... 详细信息

在运输振动测量数据基础上,本文提出了基于工作模态辨识的高速飞行器运输约束动载荷辨识方法。首先,详细介绍了era(Eigensystem Realization Algorithm)环境激励模态辨识方法的理论和载荷辨识时域方法的理论;其次,给出了飞行器结构动力学建模方法;再次,提出了基于工作模态辨识的高速飞行器运输约束动载荷辨识计算工作流程,详细分析了各操作步骤;最后,通过算例验证了方法的可行性,其中,基于振动测量数据,采用环境激励模态辨识方法辨识各时刻的模态,包括模态频率和模态振型,再利用振动响应的模态叠加原理和模态正交理论,获取各时刻飞行器低阶模态的响应,再结合模态剪力和模态弯矩进行动载荷识别,采用载荷识别方法获取了高速飞行器约束点的约束载荷时域历程。

关键词：模态辨识 era 工作模态动载荷振动载荷识别

未来与科技的融合广汽era纪元概念车设计解析

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汽车之友 2024年第2期 76-79页

在2023年的广州车展上,广汽集团推出了全新智净旗舰氢电概念车一一era纪元。它是一款集高科技、高性能和环保于一身的智能电动跨界轿跑SUV车型。这款全尺寸跨界轿跑SUV不仅凭借其独特设计吸引了无数眼球,更以其前瞻的智能化特性,引领着... 详细信息

在2023年的广州车展上,广汽集团推出了全新智净旗舰氢电概念车一一era纪元。它是一款集高科技、高性能和环保于一身的智能电动跨界轿跑SUV车型。这款全尺寸跨界轿跑SUV不仅凭借其独特设计吸引了无数眼球,更以其前瞻的智能化特性,引领着未来汽车的发展方向。

关键词：广州车展未来汽车 SUV车型概念车全尺寸 era 高科技智能化

Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting era to inhibit RANKL signaling

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Acta Pharmaceutica Sinica B 2021年第2期11卷 442-455页

作者： Keqi Wang Yongyan Chen Shuo Gao Maosi Wang Mengmeng Ge Qian Yang Mingkai Liao Lin Xu Junjie Chen Zhiping Zeng Haifeng Chen Xiao-kun Zhang Ting Lin Hu Zhou School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchXiamen UniversityXiamen 361102China High Throughput Drug Screening Platform Xiamen UniversityXiamen 361102China

Although different types of drugs are available for postmenopausal osteoporosis,the limitations of the current therapies including drug resistances and adverse effects require identification of novel anti-osteoporosis agents.Here,we defined that norlichexanthone(NOR),a natural product,is a ligand of estrogen receptor-alpha(ERα)and revealed its therapeutic potential for postmenopausal osteoporosis.We used mammalian-one hybrid assay to screen for ERαmodulators from crude extracts of several plant endophytes.As a result,NOR purified from the extract of endophyte ARL-13 was identified as a selective ERαmodulator.NOR directly bound to ERαwith an affinity in nanomolar range,revealing that it is a natural ligand of ERα.NOR induced osteoblast formation in MC3T3-E1 precursor cells.Conversely,NOR inhibited receptor activator of nuclear factor-kappa B ligand(RANKL)-induced osteoclast formation in both RAW264.7 macrophages and mouse primary monocytes.Mechanistically,NOR inhibited RANKL-induced association of ERαand TRAF6 to prevent ERα-mediated TRAF6 activation via Lys63-linked ubiquitination.Importantly,NOR exhibited potent anti-osteoporosis efficacy in an ovariectomized mouse model.Comparing to estrogen,NOR was of much less capability in stimulating endometrial hyperplasia and promoting mammalian cancer cell proliferation.Taken together,our study identified NOR as a natural and high affinity ligand of ERαwith substantial anti-osteoporosis but less estrogenic activity.

关键词： Norlichexanthone Osteoporosis Osteoclast RANKL signaling TRAF6 era

The era of Immune Checkpoint Therapy: From Cancer to Viral Infection——A Mini Comment on the 2018 Medicine Nobel Prize

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Virologica Sinica 2018年第6期33卷 467-471页

作者： Jia Liu Wen Pan Dongliang Yang Department of Infectious Diseases Union Hospital TongjiMedical College Huazhong University of Science and Technology

The 2018 Medicine Nobel Prize was awarded jointly to two immunologists, James P. Allison at the University of Texas MD Anderson Cancer Center in Houston and Tasuku Honjo at Kyoto University in Japan, who pioneered a n... 详细信息

关键词： PD In The era of Immune Checkpoint Therapy A Mini Comment on the 2018 Medicine Nobel Prize

Delineation of Nitrogen Signaling Networks: Computational Approaches in the Big Data era

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Molecular Plant 2019年第2期12卷 150-152页

作者： Yoshiaki Ueda Shuichi Yanagisawa BiotechnologyResearchCenter TheUniversityofTokyoYayoi1-1-1Bunkyo-kuTokyo113-8657Japan

Plants absorb nitrogen, an essential macronutrient, from the rhizosphere, and soil nitrogen status is thus an important determinant of plant growth and productivity. Plants have evolved numerous mechanisms to induce modulations of nitrogen metabolism and a wide range of physiological processes in response to changes in nitrogen source supply and variation in the internal abundance of nitrogen-containing compounds.

关键词： Nitrogen Signaling Networks Computational Approaches Big Data era

New era of drug innovation in China

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Acta Pharmaceutica Sinica B 2019年第5期9卷 1084-1085页

作者： Xuan Ye Qingli Wang Haixue Wang Office of Pharmacology and Toxicology Center for Drug Evaluation National Medical Products Administration

In 2018, the China National Medical Products Administration(NMPA) approved new drug applications (NDAs) of 48 new drugs, which was the highest annual approval rate by the Chinese regulatory agency in the past 20 years. Nine of the 48 new drugs,including fruquintinib, anlotinib, toripalimab and sintilimab, are global new molecular entities (NME) that were developed by Chinese pharmaceutical companies.

关键词： New era drug innovation China

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区域森林水源涵养功能评价模型的开发与应用

中国水土保持科学 2023年第1期21卷 119-127页

作者：余恩旭张明芳徐亚莉孙鹏森蒙作主电子科技大学资源与环境学院成都611731 中国林业科学研究院森林生态环境与保护研究所北京100091

区域尺度上毁林、虫害、火灾以及造林等多种类型森林变化伴随森林植被恢复生长,使森林及其水源涵养功能恢复具有时空累积性。而传统森林水源涵养功能评价方法难以直接刻画森林时空累积变化及其对水源涵养功能的影响,且存在模型计算量大... 详细信息

区域尺度上毁林、虫害、火灾以及造林等多种类型森林变化伴随森林植被恢复生长,使森林及其水源涵养功能恢复具有时空累积性。而传统森林水源涵养功能评价方法难以直接刻画森林时空累积变化及其对水源涵养功能的影响,且存在模型计算量大、效率低等问题。针对上述难题,集成自主开发的森林恢复评价模型(era模型)与经典的综合蓄水法能力,结合GIS二次开发平台,设计与实现区域森林水源涵养功能评价模型(RFWCFAM)用于不同森林恢复情境下森林景观和森林水源涵养功能的时空动态评价和预测。该模型通过输入降水、植被类型、土壤、森林恢复措施等数据,生成森林变化、水源涵养量变化、恢复措施布局等空间分布图以及相应的统计数据,可以快速、准确定量评估区域尺度森林变化及其恢复过程中水源涵养功能的时空累积变化,辨识影响森林恢复的关键因子。区域森林水源涵养功能评价模型应用于杂谷脑流域,结果表明:1)2010年流域森林总水源涵养量为679.37 t/hm^(2);2)2010—2030年间在自然恢复和人工恢复情景下流域森林土壤层、枯枝落叶层、林冠层及总水源涵养量均呈增加趋势;3)人工恢复效果较自然恢复更明显,预计到2030年人工恢复措施下森林水源涵养总量较自然恢复措施下约高5.19%。本模型的开发及成功应用能够为林业部门和水资源管理部门快速准确评估森林恢复工程对水源涵养功能的提升效果提供高效的评价工具,同时为我国森林资源适应性管理提供科学依据,为水土保持工程的评价和管理提供科学支撑。

关键词：森林恢复 era 水源涵养 GIS二次开发综合蓄水能力法水土保持

DYNAMIC MODELING AND ACTIVE CONTROL OF FLEXIBLE PLATE BASED ON THE INPUT-OUTPUT DATA

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Acta Mechanica Solida Sinica 2013年第3期26卷 255-262页

作者： Yong Xie Tong Zhao Guoping Cai Department of Engineering Mechanics State Key Laboratory of Ocean EngineeringShanghai Jiaotong University

This paper studies the low-order dynamic modeling and active control of a flexible plate and provides experimental verification. First based on the input-output data of the sys- tem, the Markov parameters of the system are identified using the method of observer/Kalman filter identification （OKID）. Then a low-order state-space model is built using the eigensystem realization algorithm （era）. Finally, a linear quadratic Gaussian （LQG） controller is designed based on the low-order state-space model. Experimental results have proved the effectiveness and feasibility of the research.

关键词： flexible plate OKID era active control experiment

Bosentan and antiretroviral therapy in an HIV/HBV/HCV coinfected Chinese patient with HIV-related pulmonary arterial hypertension

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Chinese Medical Journal 2013年第6期126卷 1197-1198页

作者： WANG Mou-yue LIU Huan Kunming Med Univ Yanan Affiliated Hosp Dept Cardiol Yunnan Cardiovasc Hosp Kunming 650051 Yunnan Peoples R China Kunming Med Univ Inst Mol & Clin Med Kunming 650500 Yunnan Peoples R China Monash Univ Monash Inununol & Stem Cell Labs Clayton Vic 3800 Australia

To the editor： Pulmonary arterial hypertension （PAH） is an infrequent but nevertheless, serious life threatening complication of human immunodeficiency virus （HIV） infection. People infected with HIV have a high prevalence of chronic hepatitis B virus （HBV） and/or hepatitis C virus （HCV）. Bosentan is effective in patients with HIV-related PAH （HRPH）;1 but hardly used on Chinese patients so far. In this rare case, we present successful, long-term coadministration of bosentan and antiretroviral therapy in an HIV/HBV/HCV coinfected Chinese patient with HRPH.

关键词： era