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基于类器官模型探究乳腺癌突变位点er、PR、Her2与药物敏感性的相关性

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罕少疾病杂志 2024年第3期31卷 60-63页

作者：吴松龄刘佳慧詹巧惠黄佳雯厦门医学院附属第二医院乳腺外科福建厦门361021

目的探索乳腺癌相关受体er、和PR、和Her2的表达量水平与20种FDA批准的肿瘤化疗药物敏感性的关系。方法收集厦门医学院附属第二医院收治的乳腺癌患者术中肿瘤组织,同时培养肿瘤组织对应的类器官,通过RT-qPCR和western blot观察类器官受... 详细信息

目的探索乳腺癌相关受体er、和PR、和Her2的表达量水平与20种FDA批准的肿瘤化疗药物敏感性的关系。方法收集厦门医学院附属第二医院收治的乳腺癌患者术中肿瘤组织,同时培养肿瘤组织对应的类器官,通过RT-qPCR和western blot观察类器官受体(er和PR、Her2)的表达情况。根据表达水平分为高表达组和低表达组,并分别观察各组类器官对包括顺铂、紫杉醇在内的20种FDA批准的化疗药物的IC50值,并通过GR50浓度对类器官的敏感性进行评分。结果培养的乳腺癌类器官具有与肿瘤组织相同的肿瘤上皮细胞和er和PR、Her2的表达情况,药敏的结果显示,乳腺癌患者类器官对奥拉帕尼和舒尼替尼、曲贝丁的评分较高,对顺铂、卡铂的敏感率较低。其中er和PR表达水平上调会增加类器官对依托泊苷、阿霉素和它莫西芬等药物的的敏感性,而会降低对紫杉醇、长春瑞滨和SN-38等的敏感性。另外,Her2表达水平上调会增加类器官对顺铂、卡铂和长春瑞滨等的敏感性,会降低对依托泊苷和吉西他滨的敏感性。结论er、PR或Her2的表达量与乳腺癌对大多数药物敏感性有显著的影响。因此,在制定治疗方案是需要考虑这些受体的表达量。

关键词：乳腺癌类器官药物敏感性 er PR Her2

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激光粉末床融合含铒铝合金研究进展

材料开发与应用 2024年第1期39卷 94-104页

作者：毕舰镭魏午翟玉妍裴瑜文胜平荣莉黄晖聂祚仁北京工业大学新型功能材料教育部重点实验室北京100124

近年来增材制造铝合金技术得到迅速发展,尤其是激光粉末床融合技术(LPBF)在部分构件上实现了应用验证。在LPBF技术中,常通过添加微量元素,如稀土铒(er)元素等,来改善合金的成形性和力学性能。本研究从er在铝合金中的作用机理出发,系统... 详细信息

近年来增材制造铝合金技术得到迅速发展,尤其是激光粉末床融合技术(LPBF)在部分构件上实现了应用验证。在LPBF技术中,常通过添加微量元素,如稀土铒(er)元素等,来改善合金的成形性和力学性能。本研究从er在铝合金中的作用机理出发,系统性概述er元素在LPBF特殊热环境中的演变机制以及时效响应。总结在LPBF工艺下,er元素在Al-Si、Al-Mg和Al-Zn-Mg-Cu合金中的存在形式和应用,对比不同含铒铝合金的力学性能,并对LPBF含铒铝合金的发展进行了展望。

关键词：激光粉末床融合技术铝合金微合金化 er Zr

铒含量对6061铝合金铸轧板材组织性能的影响

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有色金属加工 2024年第3期53卷 22-25,31页

作者：王为民孙玉崇田双永栾粟徐振辽宁科技大学材料与冶金学院辽宁鞍山114051

文章研究了微量er元素对双辊铸轧6061铝合金板材微观组织演变的影响。采用NF6-300立式双辊铸轧机制备不同er含量的6061铸轧板材,采用金相组织观察、扫描电镜和透射电镜等组织分析技术,分析了合金中er的主要存在形式和作用机制。结果表明... 详细信息

文章研究了微量er元素对双辊铸轧6061铝合金板材微观组织演变的影响。采用NF6-300立式双辊铸轧机制备不同er含量的6061铸轧板材,采用金相组织观察、扫描电镜和透射电镜等组织分析技术,分析了合金中er的主要存在形式和作用机制。结果表明,添加微量的er可以在铸轧板中形成初生Al_(3)er相,该相组织中可以成为α-Al优良的异质形核核心,可大幅细化6061铝合金铸轧板材晶粒。而且,er与Fe之间产生交互作用,组织中针条状和骨骼状的富Fe相转变为较小的短棒状和块状。但铸轧板中的er含量过多时,er元素聚集,含er稀土化合物和杂质相尺寸明显增大。

关键词：铝合金双辊铸轧 er 组织演变

Large reversible cryogenic magnetocaloric effect in rare earth iron carbides of composition RE_(2)FeC_(4)(RE=Ho,er,and Tm)

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Journal of Rare Earths 2023年第12期41卷 1996-2001,I0006页

作者： Jianjian Gong Qi Fu Hao Sun Lu Tian Xinqiang Gao Zhenxing Li Zhaojun Mo Jun Shen School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China

At cryogenic temperatures,the investigations of magnetic phase transition and magnetocaloric effect in RE_(2)FeC_(4)(RE=Ho,er,and Tm) compounds were performed.Ho_(2)FeC_(4)and er_(2)FeC_(4)compounds undergo two magnetic phase transitions with the temperature decreasing:from paramagnetic(PM) to ferromagnetic(FM) transition at their respective Curie temperature(Tc) and from FM to antiferromagnetic(AFM) or ferrimagnetic(FIM) transition below 2 K.Tm_(2)FeC_(4)compound exhibits only a second-order PM to FM phase transition at TC=K.Large reversible MCE without hysteresis loss is observed in RE_(2)FeC_(4)(RE=Ho,er,and Tm) compounds.Particularly,the maximum value of magnetic entropy change(-ASM)is 21.62 J/(kg K) under the magnetic field change(Δ_(μ0)H) of 0-5 T for er_(2)FeC_(4).The er_(2)FeC_(4)compound presenting excellent magnetocaloric performance makes it a competitive cryogenic magnetic refrigeration material.

关键词： RE_(2)FeC_(4)(RE=Ho er and Tm)compounds Magnetocaloric effect Magnetic phase transition Cryogenic magnetic refrigeration Rare earths

Yb-and er concentration dependence of the upconversion luminescence of highly doped NaYF_(4):Yb,er/NaYF_(4):Lu core/shell nanocrystals prepared by a water-free synthesis

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Nano Research 2022年第10期15卷 9639-9646页

作者： Christian Würth Bettina Grauel Monika Pons Florian Frenzel Philipp Rissiek Kerstin Rücker Markus Haase Ute Resch-Genger Federal Institute for Materials Research and Testing(BAM) Division BiophotonicsRichard-Willstaetter-Str.1112489 BerlinGermany Institut für Chemie Neuer Materialien Fachbereich Biologie/ChemieUniversität OsnabrückBarbarastraße 749076 OsnabrückGermany

High sensitizer and activator concentrations have been increasingly examined to improve the performance of multi-color emissive upconversion(UC)nanocrystals(UCNC)like NaYF_(4):Yb,er and first strategies were reported to reduce concentration quenching in highly doped UCNC.UC luminescence(UCL)is,however,controlled not only by dopant concentration,yet by an interplay of different parameters including size,crystal and shell quality,and excitation power density(P).Thus,identifying optimum dopant concentrations requires systematic studies of UCNC designed to minimize additional quenching pathways and quantitative spectroscopy.Here,we quantify the dopant concentration dependence of the UCL quantum yield(ΦUC)of solid NaYF_(4):Yb,er/NaYF_(4):Lu upconversion core/shell nanocrystals of varying Yb3+and er3+concentrations(Yb3+series:20%‒98%Yb3+;2%er3+;er3+series:60%Yb3+;2%‒40%er3+).To circumvent other luminescence quenching processes,an elaborate synthesis yielding OH-free UCNC with recordΦUC of~9%and~25 nm core particles with a thick surface shell were used.High Yb3+concentrations barely reduceΦUC from~9%(20%Yb3+)to~7%(98%Yb3+)for an er3+concentration of 2%,thereby allowing to strongly increase the particle absorption cross section and UCNC brightness.Although an increased er3+concentration reducesΦUC from~7%(2%er3+)to 1%(40%)for 60%Yb3+.Nevertheless,at very high P(>1 MW/cm^(2))used for microscopic studies,highly er3+-doped UCNC display a high brightness because of reduced saturation.These findings underline the importance of synthesis control and will pave the road to many fundamental studies of UC materials.

关键词： highly doped upconversion nanocrystals core/shell nanoparticles upconversion luminescence efficiency NaYF_(4):Yb er concentration quenching

Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions

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Journal of Genetics and Genomics 2022年第6期49卷 519-522页

作者： Tiantian Ma Feng Zhang Yaqing Wang Zhiheng Xu Center for Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Coat protein complex Ⅱ(COPⅡ)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum(er) to different destinations. c TAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPⅡ carrier and cargo trafficking through direct or indirect interaction with COPII components. c TAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying c TAGE5/MEA6-mediated cargo transport and biological functions.

关键词： cTAGE5/MEA6 COPII er Cargo secretion

Strong interface contact between NaYF_(4):Yb,er and CdS promoting photocatalytic hydrogen evolution of NaYF_(4):Yb,er/CdS composites

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Journal of Materials Science & Technology 2022年第7期102卷 1-1,2-7页

作者： Huaze Zhu Yongqiang Yang Yuyang Kang Ping Niu Xiangdong Kang Zhiqing Yang Hengqiang Ye Gang Liu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110819China Jihua Laboratory Foshan 528000China

To acquire efficient photocatalysts,it is necessary to make effective use of visible light/Near Infrared(NIR)light,which takes up a large percentage of sunlight.Integrating upconversion materials with visible light active photocatalysts has attracted much attention in this regard.The interface contact between upcon-version material and photocatalyst has potential influence on the properties and thus the performance of the system.In this work,NaYF_(4):Yb,er/CdS composites of the upconversion material NaYF_(4):Yb,er nanorods and CdS nanoparticles were synthesized by ion adsorption/precipitation process and were then annealed in an argon atmosphere at different temperatures to modulate the microstructures.The annealing pro-cess endows the crystal transformation of cubic CdS with low crystallinity to hexagonal CdS with high crystallinity and,importantly,good interface contact between NaYF_(4):Yb,er and CdS.Consequently,the hy-drogen evolution activity greatly increases from 171 to 2539μmol h^(−1) g^(−1) under the light irradiation ofλ>400 nm,and from 0 to 19μmol h^(−1) g^(−1) under the light irradiation ofλ>600 nm.This work might provide a useful reference for the rational design of promising photocatalyst involving upconversion ma-terials.

关键词： NaYF_(4):Yb er CdS Upconversion Photocatalytic Composite

TT3.1:a journey to protect chloroplasts upon heat stress

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Stress Biology 2022年第1期2卷 358-360页

作者： Jin‑Yu Li Jian‑Xiang Liu State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310027China

Rice(Oryza sativa L.)is a staple crop that feeds over half the world’s population.High temperature stress is a great threaten to sustainable agriculture and leads to yield loss and impaired grain quality in major crops.Rice is sensitive to heat stress at almost all the growth stages and the molecular mechanisms underlying responses to heat stress in rice is emerging.Through quantitative trait locus(QTL)mapping,a recent study conducted by Zhang et al.shows that one genetic locus Thermo-tolerance 3(TT3)contains two genes that are required for thermotolerance in rice.The TT3.1–TT3.2 genetic module in rice links the plasma membrane to chloroplasts to protect chloroplasts from heat stress damage and increases grain yield under heat stress conditions.This breakthrough provides a promis-ing strategy for future breeding of high temperature resilient crops.

关键词： Chloroplast er Heat stress NTL3 Plasma membrane TT3.1 TT3.2

Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development

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BIOCELL 2022年第1期46卷 87-95页

作者： YANYAN LI SHAHANAVAJ KHAN ANIS AHMAD CHAUDHARY HASSAN AHMED RUDAYNI ABDUL MALIK ASHWAG SHAMI Department of Oncology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou450007China Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)Muzaffarnagar251001India Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)Riyadh11623Saudi Arabia Department of Biology College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11617Saudi Arabia

Available reports have confirmed a link between bacterial infection and the progression of different types of cancers,including colon,lungs,and prostate cancer.Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum(er)using in-silico approaches and their possible role in lung cancer etiology.We predicted 48 proteins that target human er,which may be associated with protein folding and protein-protein interactions during infection.The results showed C.pneumoniae proteins targeting human er and their implications in lung cancer growth.These targeted proteins may be involved in competitive interactions between host and bacterial proteins,which may change the usual pathway functions and trigger the development of lung cancer.Moreover,C.pneumoniae unfolded protein accumulation in the human er possibly induces er stress,consequently activating the unfolded protein response(UPR),and providing a favorable microenvironment for cancer growth.The current study showed the C.pneumoniae protein targeting in er of host cell and their implication in lung cancer growth.These results may help researchers better manage lung cancer and establish a molecular mechanism for C.pneumoniae lung cancer association.

关键词： Bacterial infection C.pneumoniae Proteomes er Lung cancer