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Study on Pharmacokinetics of eprinomectin in Sheep Following Intravenous and Subcutaneous Administration

Agricultural Sciences in China 2003年第10期2卷 1170-1174页

作者： SHI Yan-bin, HU Zheng-yin, LUO Yong-jiang, LUO Chao-ying, SHANG Ruo-feng, LIANG Ji-lan, ZHANG Xing-guo and ZHENG Ji-fang ( Key Laboratory of New Animal Medicine Project, Ministry of Agricultrue/Lanzhou Institute of Animal Husbandry & Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R.China) Key Laboratory of New Animal Medicine Project Ministry of Agricultrue/Lanzhou Institute of Animal Husbandry & Veterinary Pharmaceutics Science Chinese Academy of Agricultural Sciences Lanzhou 730050 P. R. China

A RP-HPLC method was used for the determination of eprinomectin concentration in sheep plasma following i.v. and s.c. administration at a single dose of 0.2 mg kg 1. eprinomectin in plasma within 2.5200 ng ml 1 ranges had a good linear relationship(R=0.9968).The average recovery of the method was 99.65±3.84%.The RSD% of within-day and between-day assays were less than 10 and 12%, respectively. The extract of plasma samples were loaded onto a C 18 catridge. After solvent exchange, the methanol eluate was derivatized via the addition of 1-methylimidazole and trifluoroacetic anhydride in acetonitrile. The fluorescent derivative was *** main pharmacokinetic parameters were as follows, for i.v. administration: T 1/2β=12.66±2.05 h, AUC 0t= 1.02 ± 0.3 mg h L 1, f c=0.13±0.05; for s.c. administration: T 1/2Ka= 4.42 ±1.04 h, C max=0.02±0.01 μg ml 1, T max= 15.36 ± 2.91 h, t 1/2K=26.22±9.04 h, AUC 0t= 1.19±0.37 mg h L 1. The results showed that eprinomectin was distributed widely and taken long time to eliminate in sheep after i.v. adminstration. When given subcutaneously, eprinomectin had better absorption and longer residue time in *** was eliminated much slowly after s.c. adminstration compared with i.v. administration.

关键词： eprinomectin Pharmacokinetics Sheep

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