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Iloprost inhibits fracture repair in rats

Chinese Medical Journal 2014年第16期127卷 2960-2965页

作者： Ali Dogan Fatih Duygun A. Murat Kalender Irfan Bayram Ibrahim Sungur Department of Orthopedics and Traumatology Education andResearch HospitalAntalya Turkey Department of Orthopedics and Traumatology Sutcu ImamUniversity School of Medicine Kahramanmaras Turkey Department of Pathology Yuzuncu Yil University School ofMedicine Van Turkey Department of Orthopedics and Traumatology Haseki Education and Research Hospital Istanbul Turkey

Background Previous studies have shown that prostaglandins （PGs） dramatically stimulate healing processes in bone.However,the effect of prostaglandin l2 （PGI2） on fracture healing remains unclear.To investigate the effect of PGI2,a study on fracture healing process in closed tibia fractures was designed.Methods Thirty-six Sprague-Dawley male rats were randomized into two groups.On the first day,their right tibias were fractured by three-point bending technique.The study group （n=18） received a single injection of 10 μg/kg iloprost for 5 days,while the control group （n=18） received saline solution in the same way.On the 7th,14th and 28th days following the fracture,six rats were sacrificed and their right legs were harvested in each group.The progression of fracture healing was assessed for each specimen by the scores of radiography （by Lane-Sandhu） and histology （by Huo et al）.Results On the 7th day,the radiographic and histologic scores were equal.On the 14th day radiographic total score was 6 and histologic total score was 23 in the iloprost group,whereas radiographic total score was 11 and histologic total score was 33 in the control group.On the 14th day radiographic and histologic scores were significantly decreased in the iloprost group compared to the control group （P 〈0.05）.On the 28th day radiographic total score was 12 and histologic total score was 37 in the iloprost group,whereas radiographic total score was 15 and histologic total score was 40 in the control group.On the 28th day although there was a decrease in radiographic and histologic scores of the iloprost group acording to control group,it was not statistically significant （P 〉0.05）.Conclusion Iloprost delays fracture healing in early stage in rats.

关键词： Epoprostenol iloprost fracture healing bone rats prostaglandin I2

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Epoprostenol:临床试验及研究

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国外医学情报 1982年第6期 103-104页

作者：孙健

《美国医学会杂志》第245卷第24期（1981年）第2481页报道:Epoprostenol是前列腺素类中最新的一种,自从1976年发现以来,有关其治疗效果的资料正日益增多。英国贝克纳姆的巴勒斯·韦尔康姆基金会的研究组主任理学博士文氏（John Vane）... 详细信息

《美国医学会杂志》第245卷第24期（1981年）第2481页报道:Epoprostenol是前列腺素类中最新的一种,自从1976年发现以来,有关其治疗效果的资料正日益增多。英国贝克纳姆的巴勒斯·韦尔康姆基金会的研究组主任理学博士文氏（John Vane）最近在美国的一次讲演中介绍了Epoprostenol。他说,复合物Epoprostenol即前列腺素Ⅱ2（PGI2）,或常称为前列腺环素,经临床试验证明有抑制血小板聚集的作用。另一些有关Epoprostenol的情报是在一次论述前列腺素在脑血管与凝血病症的会议上

关键词：血小板数前列腺素女用避孕药临床试验 Epoprostenol 心脏外科手术体外循环促凝血素透析疗法血液透析抑制血小板聚集德格拉毫微克心脏直视手术医学院校医学院凝血时间病人血管扩张蛋白多糖肝素过氧化物

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Management of portopulmonary hypertension:New perspectives

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World Journal of Gastroenterology 2013年第45期19卷 8252-8257页

作者： Luigi Mancuso Francesca Scordato Michela Pieri Eliana Valerio Andrea Mancuso Department of Cardiologia Ospedale Cervello90100 Palermo Italy Cardiologia Clinica Candela 90100 Palermo Italy Epatologia e Gastroenterologia Ospedale Niguarda Cà Granda Milano 20162 Milano Italy Medicina Interna 1 ARNAS Civico 90100 Palermo Italy

Portopulmonary hypertension(PPHTN)is a known complication of cirrhosis.Moderate-to-severe PPHTN implies an extremely poor prognosis.It occurs in 5%-10%of patients referred for liver transplantation(LT),and probably with an higher incidence in patients with large portosystemic shunts.Patients with moderate-tosevere pulmonary hypertension have been previously excluded from LT because of the extremely high surgical risk and since the post-transplant outcome reported was poor.Recently,new perspectives in the management of patients with portopulmonary hypertension are emerging.In fact,some pulmonary vasoactive drugs have become routine in the treatment of patients with idiopathic pulmonary hypertension.These drugs,particularly Epoprostenol,have been recently introduced in the treatment of patients with PPHTN,and have been shown to be effective in reducing pulmonary artery pressure as well as pulmonary vascular resistances.Furthermore,recent studies seem to demonstrate that treatment with pulmonary vasoactive drugs could allow liver transplantation with acceptable surgical risks and excellent survival.Although there are not large series nor prospective studies addressing this topic,the clinical scenario of patients with PPHTN seems to be positively changing.

关键词： Portopulmonary hypertension Cirrhosis Liver transplantation Management Epoprostenol

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Plasma endothelin in patients with endotoxemia and dynamic comparison between vasoconstrictor and vasodilator in cirrhotic patients

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World Journal of Gastroenterology 2001年第1期7卷 126-127页

作者： Feng Liu1 Ji Xin Li2, Chun Mei Li2 Xi Sheng Leng2 1Department of General Surgery, the Fifth Affiliated Hospital, Harbin Medical University, Harbin 150036, Heilongjiang Province, China2Department of General Surgery, People’s Hospital, Medical University, Beijing 100044, China Department of General Surgery the Fifth Affiliated Hospital Harbin Medical UniversityHarbin 150036 Heilongjiang Province China. ***

INTRODUCTIONPortal hypertension is a common clinical syndromecharacterized by an abnormal increase in portalblood to the systemic circulation, bypassing theliver. Recent studies have reported that humoralsubstances play an important role in thepathogenesis of portal hypertension, either byincreasing vascular resistance at both theintrahepatic and porto-collateral sites or affectingsplanchnic vasodilation with a concomitant increasein parto-collateral blood flow[1-6]

关键词： hypertension, portal liver cirrhosis portosystemic shunt, surgical endothelins radioimmunoassay Epoprostenol liver cirrhosis

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