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Rumen microbiota-host transcriptome interaction mediates the protective effects of trans-10,cis-12 CLA on facilitating weaning transition of lambs

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Animal Nutrition 2023年第1期12卷 345-359页

作者： Chunlei Yang Xiangfei Deng Peter Lund Haixia Liu Xingwang Ding Zhengwei Fu Naifeng Zhang Jinjun Li Lifeng Dong College of Biotechnology and Bioengineering Zhejiang University of TechnologyHangzhou310014China Department of Animal Science Aarhus UniversityAU FoulumDK-8830TjeleDenmark Jiangsu Agri-animal Husbandry Vocational College Taizhou225300China Institute of Feed Research Chinese Academy of Agricultural Sciences/Sino-US Joint Lab on Nutrition and Metabolism of RuminantBeijing100081China Institute of Food Sciences Zhejiang Academy of Agricultural SciencesHangzhou310021China

Developing alternatives to antibiotics for prevention of gastrointestinal dysbiosis in early-weaning farmed animals is urgently *** study was to explore the potential effects of trans-10,cis-12 conjugated linoleic acid(CLA)on maintaining ruminal homeostasis of young ruminants during the weaning transition *** neonatal lambs were selected(6 lambs per group)and euthanized for rumen microbial and epithelial *** lambs were weaned at 28 d and experienced the following 5 treatments:euthanized on d 28 as the pre-weaning control(CON0),fed starter feed for 5(CON5)or 21(CON21)d,fed starter feed with 1%of CLA supplemented for 5(CLA5)or 21(CLA21)*** showed that the average daily weight gain and dry matter intake were significantly higher in CLA5 than CON5 *** compared with the CON5 and CON21 group,the relative abundances of volatile fatty acid(VFA)producing bacteria including Bacteroides,Treponema,Parabacteroides and Anaerovibrio,as well as the concentrations of acetate,butyrate and total VFA were significantly increased in CLA5 and CLA21 group,*** microbial profiling and epithelial transcriptome results showed that 7 downregulated inflammatory signaling-related host genes IL2RA,CXCL9,CD4,CCR4,LTB,SPP1,and BCL2A1 with CLA supplementation were significantly negatively correlated with both VFA concentration and VFA producing bacteria,while 3(GPX2,SLC27A2 and ALDH3A1)and 2(GSTM3 and GSTA1)upregulated metabolism-related genes,significantly positively correlated with either VFA concentration or VFA producing bacteria,*** confirm the effects of CLA on epithelial signal transduction,in vitro experiment was further conducted by treating rumen epithelial cells without or with IL-17A+TNF-αfor 12 h after pretreatment of 100μM CLA or not(6 replicates per treatment).The results demonstrated the anti-inflammatory effect of CLA via suppressing the protein expression of NF-кB p-p65/p65 with the activation of peroxisome prol

关键词： Trans-10,cis-12 conjugated linoleic acid Rumen microbiota epithelial transcriptome Peroxisome proliferator-activated receptor gamma Weaning stress

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