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Study of negatives symptoms in first episode schizophrenia

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Open Journal of Psychiatry 2013年第3期3卷 323-328页

作者： Vivek Bambole Nilesh Shah Shushma Sonavane Megan Johnston Amresh Shrivastava Department of Psychiatry Elgin Early Intervention Program for Psychosis Lawson Health Research Institute The University of Western Ontario London Canada Department of Psychiatry LTMG Medical College University of Mumbai Mumbai India Department of Psychology University of Toronto Toronto Canada LTM Medical College University of Mumbai Mumbai India

Background: Prevalence of negative symptoms in the early phase of schizophrenia remains uncertain. Negative symptoms are the primary cause of long term disability and poor functional outcome. The purpose of this study is to examine the presence of negative symptoms in patients with fist episode psychosis in schizophrenia who were hospitalized. Methods: Negative symptoms were measured in 72 patients presenting with FEP using the scale for assessment of negative symptoms (SANS) and ascertained diagnosis using DSM-IV. Prevalence of SANS items and subscales were examined for both schizophrenia and bipolar disorder. Results: This study shows that a significant number of patients with first episode schizophrenia had negative symptoms 66 (87.5%). All five subtypes of negative symptoms were present in 47% of patients suggesting primary negative symptoms, and about 40% have secondary negative symptoms. Independently, each subtype of negative symptoms was seen in 48% - 76% of patients. The most prevalent negative symptom in first-episode schizophrenia was found to be blunting (72%). 46% of patients had significant level of depression, overall psychopathology was severe and level of functioning was poor. We found that 45.8% patients were prescribed anticholinergic medications which indicated that at least 45% subjects had extra-pyramidal symptoms (EPS). Conclusion: Primary negative symptoms are prevalent in about half of First episode Psychosis (FEP) schizophrenia patients. These findings have implications for identification, early treatment, and reduced treatment resistance for negative symptoms in order to increase social and clinical outcome of schizophrenia. Further research is required in this area.

关键词： Negative Symptoms First episode Psychosis Schizophrenia Symptomatology

Amphetamine Versus Non Amphetamine-Related First episode Psychosis in Saudi Arabian Patients

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Pharmacology & Pharmacy 2011年第3期2卷 101-108页

作者： Ehab Said EL Desoky Ashraf M A El-Tantawy Yasser M. Raya Abdulhameed Al-Yahya 不详

Background: Amphetamines are illicit psychostimulant drugs that can induce psychotic symptoms. Very few studies have been conducted in Kingdom of Saudi Arabia (SA) on amphetamine abuse and related psychosis. Recently, the pattern of amphetamine abuse in SA showed a significant trend of increased frequency. Objectives: To investigate the extent of amphetamine abuse in a sample of Saudi patients hospitalized for first episode of acute psychosis. Also, to compare in that sample between amphetamine psychosis and other psychoses regarding demographic data, premorbid personality and symptoms profile. Method: 106 patients with acute psychosis were hospitalized and screening of urine for amphetamine was conducted for all. Patients’ psychiatric evaluation included interviewing, and ICD-10 criteria for personality disorders. 30 healthy subjects were also included for comparison with patients. Results: 34/106 of psychotic patients (32%) were positive for amphetamine in urine (≥ 1000 ng/ml). The frequency of personality disorders was significantly higher (P episode of acute psychosis can help and support the clinical distinction of

关键词： Amphetamine First episode Psychosis

A preliminary study on the alterations of grey matter volume in patients with early adulthood episode schizophrenia

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China Medical Abstracts(Internal Medicine) 2012年第4期29卷 238-239页

作者：刘萍萍 Dept Psychiat 1st Affil Hosp Kunming Med Univ

Objective To investigate the grey matter volume in patients with early adulthood episode (18-25 ages)schizophrenia and the correlations between regional volume and symptoms severity. Methods Twenty-one schizophrenia p... 详细信息

关键词： schizophrenia alterations episode severity preliminary gyrus matched twenty inferior bilateral

Brain activation before and after cognitivebehavior therapy in first-episode patients with mildto-moderate major depressive disorder

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China Medical Abstracts(Internal Medicine) 2014年第3期31卷 193-194页

作者：谭雅容 Dept Med Psychol Nanjing Brain HospNanjing Med Univ

Objective To explore the neurobiological mechanisms underlying cognitive-behavior therapy(CBT)for major depressive disorder(MDD)by detecting the neural changes of patients following *** Thirteen first-episode treatment-naive patients with MDD and 13 matched healthy volunteers underwent fM RI *** the patients were treated with 6-week CBT only and scanned again after treatment.A gender recognition

关键词： moderate episode detecting scanned naive matched gender gyrus inferior again

episode:互动小说移动应用市场的先驱

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出版参考 2020年第4期 16-19页

作者：徐丽芳陆文婕武汉大学数字出版研究所武汉大学信息管理学院

艾匹·德互动公司(episode Interactive)开发的移动应用程序episode是全球最早开发的互动小说应用之一,也是目前世界上最大的移动叙事网络和平台之一。凭借对移动娱乐市场的敏锐嗅觉,它在欧美移动互动小说市场取得了先发优势,构建了以... 详细信息

艾匹·德互动公司(episode Interactive)开发的移动应用程序episode是全球最早开发的互动小说应用之一,也是目前世界上最大的移动叙事网络和平台之一。凭借对移动娱乐市场的敏锐嗅觉,它在欧美移动互动小说市场取得了先发优势,构建了以用户生成内容(UGC)、自主研发、IP改编三端驱动内容生产,以年轻女性群体为主要受众,以付费道具模式和广告为主要收入来源的成熟出版生态和商业模式,并拥有世界上最大的互动叙事创作者社区之一。虽然由于受受众群体、内容主题和资本博弈等因素的影响,移动互动小说市场的竞争异常激烈,但episode凭借着良好的用户基础和在UGC领域的多年耕耘,有应对挑战的资本和信心。

关键词：互动叙事互动小说移动应用 episode