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Food Quality and Safety 2024年第3期8卷 577-588页

作者： Zhilong Xu Juxin Pei Jun Mei Huijie Yu Siyuan Chu Jing Xie College of Food Science and Technology Shanghai Ocean UniversityShanghaiChina National Experimental Teaching Demonstration Center for Food Science and Engineering Shanghai Ocean UniversityShanghaiChina Shanghai Engineering Research Center of Aquatic Product Processing and Preservation ShanghaiChina Shanghai Professional Technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation ShanghaiChina

The effect of gum tragacanth(GT)and sodium alginate(SA)active coatings incorporated with epigallocatechin gallate(EGCG;0.16%,0.32%,and 0.64%,respectively)on the quality of large yellow croaker fillets was evaluated during superchilling storage at–3˚C for 42 *** results revealed that the GT-SA-EGCG active coatings delayed microbial spoilage by reducing the total viable counts of Pseudomonas *** psychrophile bacteria and retarded the degradation of the physical properties of water-holding capacity,cooking loss,color,odor and ***-SA-EGCG coatings could also maintain fillet freshness by maintaining lower total volatile basic nitrogen,K value,and histidine content,inhibiting myofibrillar protein degradation during superchilling *** results suggested that the active coatings embedded with GT-SA-EGCG could be used as a preservative to enhance the quality of large yellow croaker and prolong the shelf life by 7–14 d during superchilling storage at–3˚C.

关键词： Large yellow croaker epigallocatechin gallate active coatings superchilling quality

Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury？

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Neural Regeneration Research 2018年第1期13卷 119-127页

作者： Jiri Ruzicka Lucia Machova Urdzikova Barbora Svobodova Anubhav G. Amin Kristyna Karova Jana Dubisova Kristyna Zaviskova Sarka Kubinova Meic Schmidt Meena Jhanwar-Uniyal Pavla Jendelova Institute of Experimental Medicine Academy of Sciences of the Czech Republic Videfiska Prague Czech Republic Department of Neuroscience Charles University Second Faculty of Medicine Prague Czech Republic New York Medical College Valhalla NY USA

Systematic inflammatory response after spinal cord injury （SCI） is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate （EGCG） are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin ＋ EGCG or saline [daily intraperitoneal doses （curcumin, 6 mg/kg; EGCG 17 mg/kg）] and weekly intramuscular doses （curcumin,60 mg/kg; EGCG 17 mg/kg）] for 28 days. Rats were evaluated using behavioral tests （the Basso, Beattie, and Bresnahan （BBB） open-field locomotor test, flat beam test）. Spinal cord tissue was analyzed using histological methods （Luxol Blue-cresyl violet staining） and mmunohistochemistry （anti-glial fibrillary acidic protein, anti-growth associated protein 43）. Cytokine levels （interleukin-1β, interleukin-4, interleukin-2,interleukin-6, macrophage inflammatory protein 1-alpha, and RANTES） were measured using Luminex assay. Quantitative polymerase chain reaction was performed to determine the relative expression of genes （Sort1, Fgf2, Irf5, Mrc1, Olig2, Casp3, Gap43, Gfap, Vegf, NfκB, Cntf） related to regenerative processes in injured spinal cord. We found that all treatments displayed significant behavioral recovery, with no obvious synergistic effect after combined therapy of curcumin and ECGC. Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1β, interleukin-4 and interleukin-6 cytokines. These results imply that although the expected synergistic response of this combined therapy was less obvious, aspects of tissue regeneration and immune responses in severe SCI were evident.

关键词： spinal cord injury epigallocatechin gallate curcumin inflammatory response neural regeneration

Study on the epigallocatechin gallate and Konjac Glucomannan Mosaic Topological Structure

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Chinese Journal of Structural Chemistry 2017年第9期36卷 1447-1455页

作者：洪馨倪永升林婉媚穆若郡王林庞杰吴春华温成荣 College of Food Science Fujian Agriculture and Forestry University School of Food Science and Technology National Engineering Research Center of SeafoodDalian Polytechnic University

In order to effectively protect the activity of epigallocatechin gallate（EGCG）, we explored the protection mechanism of Konjac glucomannan（KGM） for EGCG by experiments and theory analyses. We synthesized KGM/EGCG nanofibers by using electrostatic spinning method. The microstructure of nanofibers was characterized by SEM, FTIR, TGA, XRD and Raman spectroscopic. The formation mechanism and the protection effects of KGM/EGCG nanofibers were also discussed. The results showed that the EGCG activity was protected due to the hydrogen bonds between-OH of EGCG and KGM, and EGCG was embedded in KGM nanofiber with bead style. The reducing force and DPPH scavenging ability data indicated that KGM/EGCG nanofibers have stronger antioxidant activity than the EGCG solution under the same condition. Hence, the mosaic topological structure of KGM can effectively extend the EGCG activity.

关键词： KGM epigallocatechin gallate nanofiber mosaic topology activity protection

epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication-inducible cell line

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World Journal of Gastroenterology 2011年第11期17卷 1507-1514页

作者： Wei He Li-Xia Li Qing-Jiao Liao Chun-Lan Liu Xu-Lin Chen State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academic of Sciences Wuhan 430071 Hubei Province China

AIM:To analyze the antiviral mechanism of epigallocatechin gallate(EGCG)against hepatitis B virus(HBV) ***:In this research,the HBV-replicating cell line HepG2.117 was used to investigate the antiviral mechanism of *** of EGCG was analyzed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** B virus e antigen(HBeAg)and hepatitis B virus surface antigen(HBsAg)in the supernatant were detected by enzyme-linked immunosorbent *** mRNA and pregenomic RNA(pgRNA) levels were determined by semi-quantitative reverse transcription polymerase chain reaction(PCR)*** effect of EGCG on HBV core promoter activity was measured by dual luciferase reporter *** covalently closed circular DNA and replicative intermediates of DNA were quantified by real-time PCR ***:When HepG2.117 cells were grown in the presence of EGCG,the expression of HBeAg was suppressed,however,the expression of HBsAg was not *** precore mRNA level was also downregulated by EGCG,while the transcription of precore mRNA was not *** synthesis of both HBV covalently closed circular DNA and replicative intermediates of DNA were reduced by EGCG treatment to a similar extent,however,HBV pgRNA transcripted from chromosome-integrated HBV genome was not affected by EGCG treatment,indicating that EGCG targets only replicative intermediates of DNA ***:In HepG2.117 cells,EGCG inhibits HBV replication by impairing HBV replicative intermediates of DNA synthesis and such inhibition results in reduced production of HBV covalently closed circular DNA.

关键词： Covalently closed circular DNA epigallocatechin gallate Hepatitis B virus e antigen Hepatitis B virus Precore mRNA Replicative intermediates of DNA

Structural shift of gut microbiota during chemopreventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice

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World Journal of Gastroenterology 2017年第46期23卷 8128-8139页

作者： Xin Wang Tao Ye Wen-Jie Chen You Lv Zong Hao Jun Chen Jia-Ying Zhao Hui-Peng Wang Yuan-Kun Cai Department of General Surgery The 5 People’s Hospital of ShanghaiFudan University

AIM To investigate the effect of epigallocatechin gallate(EGCG) on structural changes of gut microbiota in colorectal *** An azoxymethane(AOM)/dextran sodium sulfate(DSS)-induced colitis mouse model was established. Fortytwo female FVB/N mice were randomly divided into the following three groups: group 1(10 mice, negative control) was treated with vehicle, group 2(16 mice, positive control) was treated with AOM plus vehicle, and group 3(16 mice, EG) was treated with AOM plus EGCG. For aberrant crypt foci(ACF) evaluation, the colons were rapidly took out after sacrifice, rinsed with saline, opened longitudinally, laid flat on a polystyrene board, and fixed with 10% buffered formaldehyde solution before being stained with 0.2% methylene blue in saline. For tumor evaluation, the colon was macroscopically inspected and photographed, then the total number of tumors was enumerated and tumor size measured. For histological examination, the fixed tissues were paraffin-embedded and sectioned at 5 mm thickness. Microbial genomic DNA was extracted from fecal and intestinal content samples using a commercial kit. The V4 hypervariable regions of 16 S r RNA were PCR-amplified with the barcoded fusion primers. Using the best hit classification option, the sequences from each sample were aligned to the RDP 16 S r RNA training set to classify the taxonomic abundance in QIIME. Statistical analyses were then *** Treatment of mice with 1% EGCG caused a significant decrease in the mean number of ACF per mouse, when compared with the model mice treated with AOM/DSS(5.38 ± 4.24 vs 13.13 ± 3.02, P < 0.01). Compared with the positive control group, 1% EGCG treatment dependently decreased tumor load per mouse by 85%(33.96 ± 6.10 vs 2.96 ± 2.86, respectively, P < 0.01). All revealed that EGCG could inhibit colon carcinogenesis by decreasing the number of precancerous lesions as well as solid tumors, with reduced tumor load and delayed histological progression

关键词： epigallocatechin gallate Gut microbiota Colorectal cancer High throughput sequencing Chemoprevention Animal experiment

Effect of epigallocatechin gallate in green tea on preventing lens opacity and αB-crystallin aggregation in rat model of diabetes

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 342-347页

作者： Andita Gustria Caesary Nina Handayani Hidayat Sujuti Department of Ophthalmology Faculty of MedicineUniversitas BrawijayaDr.Saiful Anwar General HospitalMalang 65111Indonesia

AIM:To evaluate the effect of epigallocatechin gallate(EGCG) in preventing lens opacity and the aggregation of lens αB-crystallin in model rats of diabetes mellitus(DM).METHODS:This experimental study included Wistar rats for DM as in vivo models and divided into 5 *** treatment groups were administered EGCG by orally for 20d and were then assessed for their degree of lens opacity with binocular microscope and lens αB-crystallin expression from Western blot ***:Pearson correlation test and regression analysis on EGCG exposure and final random blood sugar(RBS) obtained a significance level of P<*** exposure can significantly lower RBS with an R~2 of 0.5634(56.34%).The same analysis on EGCG exposure and the degree of lens opacity obtained a significance level of P<0.05 and increased exposure to EGCG can significantly lower the degree of lens opacity with an R~2 of 0.8577(85.77%).Correlation analysis between EGCG and the expression of lens αB-crystallin can be concluded that the higher the EGCG exposure administered,the higher the native lens αB-crystallin expression and the lower the aggregate lens αB-crystallin *** was also significant effect in which every 1 mg/kg body weight dose of EGCG can increase the native lens αB-crystallin expression by 0.0063 and decrease the aggregate lens αB-crystallin expression by ***:The administration of EGCG at a dose of 300,600,and 1200 mg shows a significant effect on preventing lens opacity and aggregation of αB-crystallin in diabetic rat models and this research could be a biomolecular prevention of cataract.

关键词： diabetes mellitus epigallocatechin gallate cataract lensαB-crystallin

Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence

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Food Science and Human Wellness 2022年第4期11卷 765-770页

作者： Klaus W.Lange Katharina M.Lange Yukiko Nakamura Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge *** symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the *** potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of *** mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical ***,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are *** epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these *** clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory.A role of green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of green tea.

关键词： Green tea epigallocatechin gallate Alzheimer’s disease Neurodegeneration Prevention

Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 499-506页

作者： Irfan Ergen Burak Turgut Nevin Ilhan Diskapi YildirimBeyazit Training and Research Hospital Eye Diseases Clinic Ankara 06330 Turkey Department of Ophthalmology Faculty of Medicine Firat University Elazig 23119 Turkey Department of Biochemistry Faculty of Medicine Firat University Elazig 23119 Turkey

AIM：To compare the potential protective effects of epigallocatechin gallate（EGCG） and ellagic acid（EA） in an experimental cataract model.●METHODS：Twenty-eight Spraque-Dawley rat pups were assigned into four *** the rats,except for those in the control group,were injected subcutaneously sodium selenite to induce experimental cataract on the postpartum ninth day,and between 10 th and 14 th *** in the sham,EGCG,and EA groups were intraperitoneally administered 50 mg/（kg·d） saline solution,50 mg/（kg·d） EGCG and 200 mg/（kg·d） EA,*** reduced glutathione（GSH） and malondialdehyde（MDA） levels,total antioxidant status（TAS） and total oxidant status（TOS） in lens supernatants were ***：The mean cataract gradings in EGCG and EA groups were found to be significantly lower than that in sham group（P〈0.001）.The mean GSH levels and TASs in EGCG and EA groups were significantly higher than that in sham group while mean MDA levels and TOSs in EGCG and EA groups were significantly lower than that in the sham group（P〈0.001）.CONCLUSION：EGCG and EA have protective effects on cataract development via the inhibition of oxidative stress.

关键词： sodium selenite experimental cataract epigallocatechin gallate ellagic acid total oxidant status totalanti-oxidant status.

Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction ofα_(s1)-casein sensitized mice

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Food Science and Human Wellness 2023年第3期12卷 882-888页

作者： Qianqian Zhang Xiaofeng Yu Linghan Tian Yanjun Cong Linfeng Li Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food and HealthBeijing Technology and Business UniversityBeijing 100048China Department of Dermatology Beijing Friendship HospitalBeijing 100050China

To investigate the anti-α_(s1)-casein allergy mechanism of two tea-derived polyphenols,epigallocatechin(EGC)and epigallocatechin gallate(EGCG),BALB/c mice were sensitized and challenged withα_(s1)-casein and nutritional intervention was given by EGC and EGCG during the sensitization provocation *** main evaluation indexes used were levels of mast cell proteases,histamine,and specific antibody immunoglobulin E(IgE),as well as cytokine secretion and pathological *** results showed that both EGC and EGCG significantly reduced levels of mast cell protease,histamine,specific IgE antibodies,and Th2 cytokines in allergic *** histopathology results showed that both EGC and EGCG markedly reduced the degree of lesions in the intestine,thymus,spleen,and *** conclusions from this study can provide a theoretical basis for the mechanism by which tea polyphenols regulate food allergens.

关键词： α_(s1)-casein epigallocatechin epigallocatechin gallate Antianaphylaxis

Regulating the oxygen-atom configuration of carbon anode enabling extremely fast-charging potassium-ion hybrid capacitors

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Nano Research 2025年第1期18卷 373-381页

作者： Daping Qiu Yuehui Wang Lulu Zhang Hang Lei Haizhou Ying Jin Niu Min Li Xuelin Yang Feng Wang Ru Yang Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering and New EnergyChina Three Gorges UniversityYichang 443002China State Key Laboratory of Chemical Resource Engineering Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials and Chemical Engineering China Three Gorges UniversityYichang 443002China

Metal-ion hybrid capacitors,such as potassium-ion hybrid capacitors(PIHCs),are regarded as promising fast-charging energy storage ***,the kinetics mismatch between the battery anode and the capacitive cathode restricts their fastcharging *** constructing carbon anodes with enhanced kinetics is an innovative approach to address this ***,using epigallocatechin gallate with high oxygen content as the precursor,oxygen-enriched carbon materials(OEC)with tunable C=O content are successfully ***,the C=O content of OEC is regulated by adjusting the pyrolysis *** as an anode for PIHCs,OEC-600 with the highest C=O content exhibits an attractive fast-charging specific capacity of 135.2 mAh·g^(-1)at 20 A·g^(-1),along with a superior fast-charging cycling *** theoretical calculations,comprehensive kinetics analysis and in-situ Raman,the positive effects of C=O on the potassium storage capability and reversibility of OEC-600 are ***,PIHCs assembled based on an OEC-600 anode deliver impressive energy/power density of 145.1 Wh·kg^(-1)/45.9 kW·kg^(-1)and superior fast-charging cycling stability with 87.5%of capacity retention over 20,000 cycles at 5 A·g^(-1).This work is anticipated to provide an optional design concept toward the carbon anode for fast-charging PIHCs.

关键词： carbon anode oxygen epigallocatechin gallate potassium-ion hybrid capacitor