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Significance of regenerating islet-derived type Ⅳ gene expression in gastroenterological cancers

World Journal of Gastroenterology 2012年第27期18卷 3502-3510页

作者： Masakatsu Numata Takashi Oshima Department of Gastroenterological Surgery Kanagawa Cancer Center1-1-2 NakaoAsahi-kuYokohamaKanagawa 241-0815Japan Gastroenterological Center Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan

The regenerating islet-derived members （Reg）, a group of small secretory proteins, which are involved in cell proliferation or differentiation in digestive organs, are upregulated in several gastrointestinal cancers, functioning as trophic or antiapoptotic factors. Regenerat- ing islet-derived type Ⅳ （RegⅣ）, a member of the Reg gene family, has been reported to be overexpressed in gastroenterological cancers. RegIV overexpression in tumor cells has been associated with carcinogen- esis, cell growth, survival and resistance to apoptosis. Cancer tissue expressing RegIV is generally associated with more malignant characteristics than that with- out such expression, and RegⅣ is considered a novel prognostic factor as well as diagnostic marker in some gastroenterological cancers. We previously investigated the expression levels of RegⅣ mRNA of 202 surgical colorectal cancer specimens with quantitative real-time reverse-transcriptase polymerase chain reaction and reported that a higher level of RegⅣ gene expression was a significant independent predictor of colorec- tal cancer. The biologic functions of RegⅣ protein in cancer tissue, associated with carcinogenesis, anti- apoptosis and invasiveness, are being elucidated by molecular investigations using transfection techniques or neutralizing antibodies of RegIV, and the feasibility of antibody therapy targeting RegIV is being assessed. These studies may lead to novel therapeutic strate- gies for gastroenterological cancers expressing RegⅣ. This review article summarizes the current information related to biological functions as well as clinical impor- tance of RegⅣ gene to clarify the significance of Reg~ expression in gastroenterological cancers.

关键词： Regenerating islet-derived type Ⅳ protein Gastrointestinal neoplasms Prognosis epidermal growthfactor receptor/protein kinase b

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