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RNA‑Sequencing Reveals Gene Expression and pathway Signatures in Umbilical Cord Blood Affected by Birth Delivery Mode

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Phenomics 2023年第3期3卷 228-242页

作者： Yongjie Liu Kun Sun Yuexin Gan Han Liu Juehua Yu Wei Xu Lin Zhang Dan Chen Ministry of Education and Shanghai Key Laboratory of Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Shenzhen Bay Laboratory Shenzhen 518107China Department of Obstetrics and Gynaecology The International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Centre for Experimental Studies and Research The First Affiliated Hospital of Kunming Medical UniversityKunming 650032China Department of Immunology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Gynecology Third Xiangya Hospital of Central South UniversityChangsha 410013China Shanghai Fosun Pharmaceutical Industrial Development Co.LtdShanghai 200233China

Cesarean section(CS)confers increased risk of type I diabetes,asthma,inflammatory bowel disease,celiac disease,over-weight and obesity,etc.,in the ***,the underlying mechanism remains *** investigate the influence of CS on gene expression in cord blood,we have performed RNA-sequencing followed by single-gene analysis,gene set enrichment analysis,gene co-expression network analysis,and interacting genes/proteins analysis in eight full-term infants born by elective CS and eight matched vaginally delivered(VD)*** genes identified above were further vali-dated in another 20 CS and 20 VD *** found for the first time that mRNA expression of genes involved in immune response(IL12A,INFG,IL1B,TNF,MIF,IL4,CA1,IFI27,HLA-DOB and EPHB1)and metabolism(DLK1,CYP2A6 and GATM)were significantly influenced by ***,serum TNF-αand IFN-γwere remarkably up-regulated in the CS infants(p=5.0×10^(–4)and 3.0×10^(–3),respectively)compared to the VD *** is biologically plausible that CS may exert adverse impacts on offspring health through influencing expression of genes in the above *** findings will help understand the potential underlying mechanisms of the adverse health impacts of CS and identify biomarkers for future health of offspring born with different delivery modes.

关键词： Cesarean section Immune response Metabolism Ribosome ephrin receptor signaling pathway

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