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Photosensitizer conjugate-functionalized poly(hexamethylene guanidine) for potentiated broad-spectrum bacterial inhibition and enhanced biocompatibility

引用

Chinese Chemical Letters 2020年第9期31卷 2516-2519页

作者： Fengfeng Xiao Bing Cao Liewei Wen yanhong Su Meixiao Zhan Ligong Lu Xianglong Hu MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityJinanUniversityZhuhai 519000China

Pathogen infection is the main cause of human morbidity and *** antibiotics usually sterilize bacteria in chemical ways,which tends to develop serious antibiotic *** polymers exhibit good bacterial inhibition with less resistance,but often face severe cytotoxicity toward normal *** optimization of polymeric antimicrobials for enhanced bactericidal capacity and improved biocompatibility is quite *** addition,photodynamic therapy(PDT) is a therapeutic modality with less susceptibility to develop ***,a typical commercial polymeric antimicrobial,polyhexamethylene guanidine(PHMG) was selected for current proof-of-concept optimization due to its excellent bactericidal capacity but moderate ***-y(EoS)was copolymerized to afford EoS-labeled polymer conjugates,poly(2-(dimethylamino) ethyl methacrylate-co-eosin),P(DMAEMA-co-EoS),which was conjugated with PHMG to afford a novel polymeric antimicrobial,P(DMAEMA-co-EoS)-b-PHMG-b-P(DMAEMA-co-EoS),noted as *** could efficiently kill broad-spectrum bacteria by physical damage and photodynamic *** with PHMG,the bacterial inhibition of PEoS-PHMG was potentiated after the ***,PEoS-PHMG exhibited low cytotoxicity and minimal hemolysis,which was demonstrated by cell viability assays toward LO2 cells and RAW 264.7 cells as well as hemolytic assays against red blood *** results confirmed that the resultant PEoS-PHMG could act as promising alternative antibacterial materials with excellent broad-spectrum bacterial inhibition and favorable biocompatibility.

关键词： Poly(hexamethylene guanidine) Photodynamic therapy eosin-y Broad-spectrum bacterial Inhibition Biocompatibility

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