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Toxicity assessment of polyethylene microplastics in combination with a mix of emerging pollutants on Physalaemus cuvieri tadpoles

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Journal of environmental Sciences 2023年第5期127卷 465-482页

作者： Amanda Pereira da Costa Araújo Thiarlen Marinho da Luz Mohamed Ahmed Ibrahim Ahmed Mir Mohammad Ali Md.Mostafizur Rahman Bojan Nataraj Daniela de Melo e Silva DamiàBarceló Guilherme Malafaia Post-Graduation Program in environmental Sciences Federal University of GoiásGoianiaGO 74690-970Brazil Laboratory of toxicology Applied to the Environment Goiano Federal InstituteUrutaíGO 75790-000Brazil Plant Protection Department Faculty of AgricultureAssiut UniversityAssiut 71526Egypt Department of Aquaculture Faculty of FisheriesAquaculture&Marine ScienceSher-e-Bangla Agricultural UniversityDhaka 1207Bangladesh Department of environmental Sciences Jahangirnagar UniversitySavar 1342Bangladesh Unit of toxicology Department of ZoologySchool of Life SciencesBharathiar UniversityCoimbatore 641046India Laboratory of environmental Mutagenesis Federal University of GoiásGoianiaGO 74690-970Brazil Catalan Institute for Water Research(ICRA-CERCA) H_(2)O BuildingScientific and Technological Park of the University of GironaEmili Grahit 101Girona 17003Spain Water and Soil Quality Research Group Department of Environmental ChemistryInstitute of Environmental Assessment and Water Research(IDAEA-CSIC)JordiGirona 1826Barcelona 08034Spain Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal InstituteUrutaíGO 75790-000Brazil Post-Graduation Program in Ecology Conservationand BiodiversityFederal University of UberlandiaUberlandiaMG 38400-902Brazil Post-Graduation Programa in Biotechnology and Biodiversity Federal University of GoiásGoianiaGO 74605-050Brazil

Studies in recent years have shown that aquatic pollution by microplastics(MPs)can be considered to pose additional stress to amphibian ***,our knowledge of how MPs affect amphibians is very rudimentary,and even more limited is our understanding of their effects in combination with other emerging ***,we aimed to evaluate the possible toxicity of polyethylene MPs(PE-MPs)(alone or in combination with a mix of pollutants)on the health of Physalaemus cuvieri *** 30 days of exposure,multiple biomarkers were measured,including morphological,biometric,and developmental indices,behavioral parameters,mutagenicity,cytotoxicity,antioxidant and cholinesterase responses,as well as the uptake and accumulation of PE-MPs in *** on the results,there was no significant change in any of the parameters measured in tadpoles exposed to treatments,but induced stress was observed in tadpoles exposed to PE-MPs combined with themixture of pollutants,reflecting significant changes in physiological and biochemical *** principal component analysis(PCA)and integrated biomarker response(IBR)assessment,effects induced by pollutants in each test group were distinguished,confirming that the exposure of *** tadpoles to the PE-MPs in combination with a mix of emerging pollutants induces an enhanced stress response,although the uptake and accumulation of PE-MPs in these animalswas ***,our study provides newinsight into the danger to amphibians of MPs coexisting with other pollutants in aquatic environments.

关键词： Amphibians environmental toxicology Micropollutants Emerging pollutants Aquatic pollution Biomarkers

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专题报告-S3生物标志物与环境毒理学

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中国药理学与毒理学杂志 2006年第3期20卷 169-172页

作者： GUO Xin-Biao Department of Occupational and environmental HealthSciences School of Public Health Peking University Bei-ring 100083 China

Arsenic exposure has been associated with the development of skin lesions such as hyperpigmentation, hypopigmentation and hyperkeratosis, which may be harbingers of increased risk for cancers of the skin, bladder, lun... 详细信息

关键词： Biomarkers environmental toxicology cancers of the skin

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Stem cell toxicology:a powerful tool to assess pollution effects on human health

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National Science Review 2016年第4期3卷 430-450页

作者： Xinglei Yao Nuoya Yin Francesco Faiola Stake Key Laboratory of environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences

environmental pollution is a global problem;the lack of comprehensive toxicological assessments may lead to increased health *** fully understand the health efects of pollution,it is paramount to implement fast,eicient and speciic toxicity screening that relies on human models rather than on time-consuming,expensive and oten inaccurate tests involving live *** stem cell toxicology represents a valid alternative to traditional toxicity assays because it takes advantage of the ability of stem cells to diferentiate into multiple cell types and tissues of the human ***,this branch of toxicology provides a possibility to assess cellular,embryonic,developmental,reproductive and functional toxicity in vitro within a single system highly relevant to human *** this review,we describe the development,performance and future perspectives of stem cell toxicology,with an emphasis on how it can meet the increasing challenges posed by environmental pollution in the modern world.

关键词： stem cell toxicology embryonic stem cells mesenchymal stem cells environmental pollution environmental toxicology health efects

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