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Short-term memory of danger signals or environmental stimuli in mesenchymal stem cells： implications for therapeutic potential

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Cellular & Molecular Immunology 2016年第3期13卷 369-378页

作者： Guang-Yang Liu Yang Liu Ying Lu Ya-Ru Qin Guo-Hu Di Yong-Hong Lei Hu-Xian Liu Yan-Qi Li Chutse Wu Xian-Wen Hu Hai-Feng Duan Key Laboratory of Systems Bioengineering School of Chemical Engineering and Technology Tianjin University Tianjin China Beijing Institute of Radiation Medicine (BIRM) Beijing China 307 Hospital of the Chinese People's Liberation Army Beijing China 301 Hospital of the Chinese People's Liberation Army Beijing China Beijing Institute of Biotechnology (BIB) Beijing China

Mesenchymal stem/stromal cells （MSCs） possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals or environmental stimuli for a period of time. When treated with the pro-inflammatory factors lipopolysaccharide （LPS） or tumor necrosis factor-a （TNF-a）, MSCs display increased expression of IL-6, IL-8 and MCP-1. Following re-plating and several rounds of cell division in the absence of stimulating factors, the expression of IL-6, IL-8 and MCP-1 remained higher than in untreated cells for over 7 days. A spike in cytokine secretion occurred when cells were exposed to a second round of stimulation. We primed MSCs with LPS and LPS-primed MSCs had better therapeutic efficacy at promoting skin flap survival in a diabetic rat model than did unprimed MSCs. Finally, we found that several microRNAs, including miR146a, miR150 and miR155, along with the modification of DNA by 5-hydroxymethylcytosine （5hmC）, mediate the MSC response to LPS and TNF-e stimulation. Collectively, our data suggest that MSCs have a short-term memory of environmental signals, which may impact their therapeutic potential.

关键词： environmental stimuli mesenchymal stem cells pre-conditioning short-term memory

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Testing phaeophytinization as an index of ozone stress in trees

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Journal of Forestry Research 2023年第4期34卷 1167-1174页

作者： Evgenios Agathokleous Mitsutoshi Kitao Takayoshi Koike School of Applied Meteorology Nanjing University of Information Science and Technology(NUIST)Nanjing 210044People’s Republic of China Research Faculty of Agriculture Hokkaido UniversitySapporoHokkaido 060-8589Japan Hokkaido Research Center Forestry and Forest Products Research Institute(FFPRI)Sapporo 062-8516Japan

Ground-level ozone pollution is a menace for vegetation in the northern hemisphere,limiting photosynthetic pigments and suppressing photosynthesis in trees and other types of plants.Phaeophytinization is the process of converting chlorophylls into phaeophytins,for example by acidifi cation.Ozone is a highly oxidizing molecule and well known to degrade chlorophylls;however,the eff ect of ozone on phaeophytinization in leaves of higher plants is largely unknown.To reveal ozone eff ect on phaeophytinization and evaluate the potential of phaeophytinization as an index of ozone stress in trees,the absorbance at the optical density of 665 nm was measured before(OD_(665))and after(OD_(665a))acidifi cation in three independent experiments with nearly 30 conditions of ozone exposure.Both current ambient and elevated ozone widely aff ected phaeophytinization,as indicated by decreases or increases in the phaeophytinization quotient OD_(665)/OD_(665a).These eff ects were commonly moderate to large in magnitude and practically signifi cant,and occurred even in ozone-asymptomatic leaves.It emerges that the ozone eff ect on phaeophytinization is bimodal,likely depending on the intensity of ozone stress.These results indicate a promising feature of OD_(665)/OD_(665a)as a thorough index of ozone stress in the future,but further studies are needed to reveal the underlying biochemical mechanisms of the bimodal eff ect on phaeophytinization.

关键词： Biological stress Chemical eff ect Chlorophyll oxidation environmental stimuli Phaeophytin

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Effects of physostigmine on the conditioned locomotion and the locomotor sensitization to morphine in rats

Effects of physostigmine on the conditioned locomotion and t...

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第十二届全国心理学学术大会

作者： Xinwang Li *,Xiaolin Zhu,Ruisi Cui,Jingjing Jiao Department of Psychology,Capital Normal University,Beijing,China 100048

Repetitive exposure to opioids elicits sensitization to its psychomotor stimulating effect and environmental stimuli contribute to this effect.This study first developed a procedure that simultaneously measures conditioned hyperactivity and locomotor sensitization,and then investigated the effects of physostigmine on the development and expression of conditioned hyperactivity and locomotor sensitization in rats.Five groups of rats(10 - 12 rats

关键词： morphine physostigmine conditioned locomotion locomotor sensitization environmental stimuli rats

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