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A container-based approach for sharing environmental models as web services

International Journal of Digital Earth 2021年第8期14卷 1067-1086页

作者： Xiaohui Qiao Zhiyu Li Fengyuan Zhang Daniel P.Ames Min Chen E.James Nelsona Rohit Khattar Civil and environmental Engineering Brigham Young UniversityProvoUTUSA Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjingPeople’s Republic of China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application NanjingPeople’s Republic of China State Key Laboratory Cultivation Base of Geographical Environment Evolution(Jiangsu Province) NanjingPeople’s Republic of China

As researchers globally work towards a fully digital representation of the earth and its processes-i.e.a true Digital Earth-the need grows for software and systems to link disparate computer simulation models of various parts of the earth in a reliable and highly functional *** services have been demonstrated as an effective way to share and reuse models as they enable communication and interoperation among applications via the ***,even using well-designed software tools,it remains a daunting process to publish heterogeneous environmental models as web services and provide long-term maintenance in response to changing computational *** present an approach that enables environmental models to be published as long-term functional web services on the same platform regardless of execution mode,programming language,and computational environment *** approach adopts the OpenGMS Wrapper System(OGMS-WS)for service publishing and Docker containers for model isolation.A streamflow prediction service is developed using this approach and is applied to analyze historical streamflow trends in *** demonstrate that this approach can lower the barrier to deploying heterogeneous environmental models as long-term functional web services,contributing to the development of a Digital Earth.

关键词： environmental models container OpenGMS platform web service

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Animal models of amyotrophic lateral sclerosis： a comparison of model validity

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Neural Regeneration Research 2018年第12期13卷 2050-2054页

作者： Jessica R.Morrice Cheryl Y.Gregory-Evans Christopher A.Shaw Experimental Medicine Program University of British Columbia Vancouver Canada Department of Ophthalmology and Visual Sciences University of British Columbia Vancouver Canada Neuroscience Program University of British Columbia Vancouver Canada Department of Pathology. University of British Columbia Vancouver Canada

Animal models are necessary to investigate the pathogenic features underlying motor neuron degeneration and for therapeutic development in amyotrophic lateral sclerosis（ALS）. Measures of model validity allow for a critical interpretation of results from each model and caution from over-interpretation of experimental models. Face and construct validity refer to the similarity in phenotype and the proposed causal factor to the human disease, respectively. More recently developed models are restricted by limited phenotype characterization, yet new models hold promise for novel disease insights, thus highlighting their importance. In this article, we evaluate the features of face and construct validity of our new zebrafish model of environmentally-induced motor neuron degeneration and discuss this in the context of current environmental and genetic ALS models, including C9 orf72, mutant Cu/Zn superoxide dismutase 1 and TAR DNA-binding protein 43 mouse and zebrafish models. In this mini-review, we discuss the pros and cons to validity criteria in each model. Our zebrafish model of environmentally-induced motor neuron degeneration displays convincing features of face validity with many hallmarks of ALS-like features, and weakness in construct validity. However, the value of this model may lie in its potential to be more representative of the pathogenic features underlying sporadic ALS cases, where environmental factors may be more likely to be involved in disease etiology than single dominant gene mutations. It may be necessary to compare findings between different strains and species modeling specific genes or environmental factors to confirm findings from ALS animal models and tease out arbitrary strain-and overexpression-specific effects.

关键词： amyotrophic lateral sclerosis motor neuron degeneration face validity construct validity zebrafish models mouse models genetic models environmental models

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The importance of long-term research and monitoring in the Ross Sea

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Advances in Polar Science 2019年第4期30卷 359-361页

作者： Bob ZUUR 机构不祥

The Ross Sea region is a biologically rich and dynamic environment and,although protected under various instruments of the Antarctic Treaty System,is threatened by a changing climate and increasing human activities locally and *** opinion editorial describes the importance of research and monitoring in the Ross Sea and identifies opportunities and barriers to enhance them.

关键词： Ross Sea human impacts toothfish fishery environmental models CCAMLR Ecosystem MonitoringProgram (CEMP) Marine Protected Areas (MPAs)

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