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Relationship between entero-hepatic bile acid circulation and interdigestive migrating myoelectrical activity in rats

引用

World Journal of Gastroenterology 2005年第34期11卷 5377-5380页

作者： Ping Fang Lei Dong Wei-Jin Zhang Jin-Yan Luo Department of Internal Medicine Second Hospital of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Division of Cardiovascular Physiology and Pharmacology Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM： To investigate the effects of entero-hepatic bile add circulation on the inter-digestive migrating myoelectrical complex （MMC） in rats. METHODS： Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of Uhem were ligatecl around the upper part of common bile duct （CBD）. The experiments were performed in consdous and fasting state. The gastrointestinal myoelectrical activity was recorded. Ursodeoxycholic acid （UDCA） and saline were then perfused into stomachs of two groups with CBD obstruction and the effects of them on the MMC were observed. RESULTS： A typical pattern of MMC was observed in normal fasting rats. MMC of antral and duodenal origin disappeared temporarily in earlier stage of CBD obstruction. While MMC of jejunum origin appeared. increased MMC cycle duration was seen after 4 d in rats with CBD obstruction. The MMC after CBD obstruction was characterized by an increased duration of phase Ⅱ-like activity and decreased duration of phase Ⅰ ＆ Ⅲ activity. Perfusion into stomachs with UDCA resulted in a shorter MMC cycle duration and a longer duration of phase III of duodenal origin compared to the normal group. CONCLUSION： entero-hepatic bile add drculation initiates inter-digestive MMC of duodenal origin.

关键词： Migrating myoelectrical complex entero-hepatic bile acid circulation Ursodeoxycholic acid Common bile duct obstruction

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