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Effect of food restriction on the energy metabolism of the Chinese bulbul（Pycnonotus sinensis）

Zoological Research 2015年第2期36卷 79-87页

作者： Qing-Jian LIANG Lei ZHAO Jia-Qi WANG Qian CHEN Wei-Hong ZHENG Jin-Song LIU School of Life and Environmental Sciences Wenzhou University Wenzhou 325035 China Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection Wenzhou 325035 China Institute of applied ecology Wenzhou University Wenzhou 325035 China

Food resources play an important role in the regulation of animals’ physiology and behavior. We investigated the effect of short-term food restriction on metabolic thermogenesis of Chinese bulbuls（Pycnonotus sinensis） by measuring changes in body mass, body fat, basic metabolic rate（BMR）, and organ mass of wild-caught Chinese bulbuls from Wenzhou, China. Short-term food restriction induced a significant decrease in body mass and body fat but body mass returned to normal levels soon after food was no longer restricted. Food restriction caused a significant reduction in BMR after 7 days（P〈0.05）, which returned to normal levels after food restriction ceased. Log total BMR was positively correlated with log body mass（r2=0.126, P〈0.05）. The dry masses of livers and the digestive tract were higher in birds that had been subject to temporary food restriction than in control birds and those subject to continual food restriction（P〈0.001 and P〈0.05, respectively）. There was also significant differences in the dry mass of the lungs（P〈0.05）, heart（P〈0.01）, and spleen（P〈0.05） in birds subject to short-term food restriction compared to control birds and those subject to continual food restriction. BMR was positively correlated with body and organ（heart, kidney and stomach） mass. These results suggest that the Chinese bulbul adjusts to restricted food availability by utilizing its energy reserves, lowering its BMR and changing the weight of various internal organs so as to balance total energy requirements. These may all be survival strategies that allow birds to cope with unpredictable variation in food abundance.

关键词： Basic metabolic rate energy metabolism Food restriction Pycnonotus sinensis

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Effect of the Shensong Yangxin Capsule on energy metabolism in Angiotensin II-lnduced Cardiac Hypertrophy

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Chinese Medical Journal 2018年第19期131卷 2287-2296页

作者： Bei-Lei Liu Mian Cheng Shan Hu Shun Wang Le Wang Zheng-Qing Hu Cong-Xin Huang Hong Jiang Gang Wu Department of Cardiology Renmin Hospital of Wuhan University Cardiovascular Research Institute Hubei Key Laboratory of Cardiology Wuhan Hubei 430060 China Department of Geriatrics Tongji Hospital Tongji Medical Corlege Huazhong University of Science and Technology Wuhan Hubei 430074 China Department of Cardiology Ezhou Hospital Renmin Hospital of Wuhan University Ezhou Hubei 436000 China

Background：Shensong Yangxin Capsule （SSYX）,traditional Chinese medicine,has been used to treat arrhythmias,angina,cardiac remodeling,cardiac fibrosis,and so on,but its effect on cardiac energy metabolism is still not *** objective of this study was to investigate the effects of SSYX on myocardium energy metabolism in angiotensin （Ang） Ⅱ-induced cardiac ***：We used 2 μl （10-6 mol/L） AngⅡ to treat neonatal rat cardiomyocytes （NRCMs） for 48 *** α-ac tinin staining showed that the myocardial cell volume *** of the cardiac hypertrophic marker-brain natriuretic peptide （BNP） messenger RNA （mRNA） also increased by real-time polymerase chain reaction （PCR）.Therefore,it can be assumed that the model of hypertrophic cardiomyocytes was successfully ***,NRCMs were treated with 1 μl of different concentrations of SSYX （0.25,0.5,and 1.0 μg/ml） for another 24 *** explore the time-depend effect of SSYX on energy metabolism,0.5 μg/ml SSYX was added into cells for 0,6,12,24,and 48 *** was assessed by MitoTracker staining and confocal *** and protein expression of mitochondrial biogenesis-related genes-Peroxisome proliferator-activated receptor-γ coactivator-1 α （PGC-1 α）,energy balance key factor -adenosine monophosphate-activated protein kinase （AMPK）,fatty acids oxidation factor-camitine palmitoyltransferase-1 （CPT-1）,and glucose oxidation factor-glucose transporter-4 （GLUT-4） were measured by PCR and Western blotting ***：With the increase in the concentration of SSYX （from 0.25 to 1.0 μg/ml）,an increased mitochondrial density in Angll-induced cardiomyocytes was found compared to that of those treated with Angll only （0.25 μg/ml,18.3300 ± 0.8895 vs.24.4900 ± 0.9041,t =10.240,P 〈 0.0001;0.5 μg/ml,18.3300 ± 0.8895 vs.25.9800 ± 0.8187,t =12.710,P 〈 0.0001;and 1.0 μg/ml,18.3300 ± 0.8895 vs.24.2900 ± 1.3120,t =9.902,P 〈 0.0001;n =5 per dosage group）.SSYX also increased the mRNA and protein

关键词： AMP-Activated Protein Kinase Cardiac Hypertrophy energy metabolism Peroxisome Proliferator-Activated ReceptorGamma Coactivator- 1 Alpha Shensong Yangxin Capsule

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Danqi Tablet(丹七片)Regulates energy metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway

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Chinese Journal of Integrative Medicine 2021年第8期27卷 597-603页

作者： MENG Hui WANG Qi-yan LI Ning HE Hao LU Wen-ji WANG Qi-xin SUN Xiao-qian JIAO Shi-hong WANG Yong TU Peng-fei Modern Research Center for Traditional Chinese Medicine School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing100029China School of Life Sciences Beijing University of Chinese MedicineBeijing100029China College of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective To investigate the cardioprotective effect of Danqi Tablet(DQT,丹七片)on ischemic heart model rats and the regulative effect on energy metabolism through peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α).Methods Rat ischemic heart model was induced by ligation of left anterior descending coronary *** 40 Sprague-Dawley rats were randomly divided into sham group,model group,DQT group(1.5 mg/kg daily)and trimetazidine(TMZ)group(6.3 mg/kg daily)according to a random number table,10 rats in each ***-eight days after continuous administration,cardiac function was assessed by echocardiography and the structures of myocardial cells were observed by hematoxylin-eosin *** level of adenosine triphosphate(ATP)in myocardial cells was measured by ATP assay *** level of key transcriptional regulators,including PGC-1α,Sirtuin 1(SIRT1),AMP-activated protein kinase(AMPK),and downstream targets of PGC-1α,such as mitofusin 1(MFN1),mitofusin 2(MFN2)and superoxide dismutase 2(SOD2)were measured by Western *** level of PGC-1αwas examined by immunohistochemical *** The rat ischemic heart model was successfully induced and the heart function in model group was *** with the model group,DQT exerted cardioprotective effects,up-regulated the ATP production in myocardial cells and inhibited the infiltration of inflammatory cells in the margin area of infarction of the myocardial tissues(Penergy metabolism in rats with ischemic heart model through AMPK/SIRT1-PGC-1α***-1αmight serve as a promising target in the treatment of ischemic heart disease.

关键词： Danqi Tablet ischemic heart disease energy metabolism peroxisome proliferator-activated receptor-γcoactivator-1α

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Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats： a 31p-magnetic resonance spectroscopy study

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Chinese Medical Journal 2014年第5期127卷 937-944页

作者： Sun Yingwei Pan Shinong Chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong Department of Radiology Shengjing Hospital of China Medical UniversityShenyang Liaoning 110004 China

Background Little is known about the value of 31P-magnetic resonance spectroscopy （31P-MRS） in in vivo assessment of exhaustive exercise-induced injury in skeletal *** aimed to evaluate the value of a 31P-MRS study using the quadriceps femoris after a single bout of acute exhaustive swimming in rats,and the correlation between 31P-MRS and histological *** Sixty male Sprague-Dawley rats were randomly assigned to control,half-exhaustive,and exhaustive exercise groups.31P-MRS of the quadriceps femoris of the right lower limb was performed immediately after swimming exercise to detect Pi,PCr,and β-*** Pi/PCr,Pi/β-ATP,PCr/β-ATP,and PCr/（PCr＋Pi） were calculated and pH *** under the receiver operating characteristic curve （AUCs） were calculated to evaluate the diagnostic potential of 31P-MRS in identifying and distinguishing the three *** staining,electron microscopy and desmin immunostaining after imaging of the muscle were used as a reference *** correlation between 31P-MRS and the mean absorbance （A value） of desmin staining were analyzed with the Pearson correlation *** Pi,PCr,Pi/PCr,and PCr/（PCr＋Pi） showed statistically significant intergroup differences （P＜0.05）.AUCs of Pi,PCr,Pi/PCr,and PCr/（PCr＋Pi） were 0.905,0.848,0.930,and 0.930 for the control and half-exhaustive groups,while sensitivity and specificity were 90％/85％,95％/55％,95％/80％,and 90％/85％,*** AUCs of Pi,PCr,Pi/PCr and PCr/（PCr＋Pi） were 0.995,0.980,1.000,and 1.000 for the control and exhaustive groups,while sensitivity and specificity were 95％/90％,100％/90％,100％/95％,and 100％/95％,*** AUCs of Pi,PCr,Pi/PCr,and PCr/（PCr＋Pi） were 0.735,0.865,0.903,and 0.903 for the half-exhaustive and exhaustive groups,while sensitivity and specificity were 80％/60％,90％/75％,95％/65％,and 95％/70％,*** the half-exhaustive group,some muscle fibers exhibited edema in HE staining,and the unclear Z-discs and the mitochondria with vacuolar degener

关键词： magnetic resonance spectroscopy exhaustive exercise energy metabolism receiver operating characteristic curve

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Early-life nutrition and metabolic disorders in later life:a new perspective on energy metabolism

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Chinese Medical Journal 2020年第16期133卷 1961-1970页

作者： Li-Yuan Zhou Ming-Qun Deng Qian Zhang Xin-Hua Xiao Key Laboratory of Endocrinology of National Health Commission Department of EndocrinologyPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Type 2 diabetes mellitus and metabolic disorders have become an epidemic ***,the pathogenesis remains largely unclear and the prevention and treatment are still *** addition to environmental factors during adulthood,early life is the critical developmental window with high tissue plasticity,which might be modified by external environmental *** evidence has demonstrated the vital role of early-life nutrition in programming the metabolic disorders in later *** this review,we aim to overview the concepts of fetal programming and investigate the effects of early-life nutrition on energy metabolism in later life and the potential epigenetic *** related studies published on PubMed database up to March 2020 were *** results showed that both maternal overnutrition and undernutrition increased the riskes of metabolic disorders in offspring and epigenetic modifications,including DNA methylation,miRNAs,and histone modification,might be the vital *** beneficial effects of early-life lifestyle modifications as well as dietary and nutritional interventions on these deleterious metabolic remolding were initially ***,characterizing the early-life malnutrition that reshapes metabolic disease trajectories may yield novel targets for early prevention and intervention and provide a new point of view to the energy metabolism.

关键词： Early-life nutrition energy metabolism Epigenetics In later life

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Bone functions as a novel endocrine organ in energy metabolism

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Chinese Medical Journal 2012年第22期125卷 4117-4121页

作者： CHEN Xiang TIAN Hao-ming PEI Fu-xing YU Xi-jie Sichuan Univ Lab Endocrinol & Metab W China Hosp Chengdu 610041 Sichuan Peoples R China Sichuan Univ Dept Endocrinol W China Hosp Chengdu 610041 Sichuan Peoples R China Sichuan Univ Dept Orthoped W China Hosp Chengdu 610041 Sichuan Peoples R China

The classic endocrine concept is a matter of dispute. The term ＂endocrine＂ denotes internal secretion of bioactive substances, in contrast to ＂exocrine,＂ which denotes secretion outside the body. Traditionally, the endocrine organs refer to classic organs, such as the thyroid, gonadal, or adrenal glands; however, some non-classic endocrine organs have been shown to have endocrine functions. For example,

关键词： bone osteocalcin endocrine function energy metabolism feedback loop

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An enhanced network of energy metabolism,lysine acetylation,and growth-promoting protein accumulation is associated with heterosis in elite hybrid rice

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Plant Communications 2023年第4期4卷 146-159页

作者： Xuan Ma Qingxiao Jia Sheng Li Zhengting Chen Xin Ming Yu Zhao Dao-Xiu Zhou National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Institute of Plant Science Paris-Saclay(IPS2) CNRSINRAEUniversity Paris-Saclay91405 OrsayFrance

Heterosis refers to the superior performance of a hybrid compared with its parental *** several genetic and molecular models have been proposed to explain heterosis,it remains unclear how hybrid cells integrate complementary gene expression or activity to drive heterotic *** this work,we show that accumulation of growth-promoting and energy metabolism proteins,enhanced energy metabolism activities,and increased protein lysine acetylation were associated with superior growth of the panicle meristem in the elite hybrid rice Shanyou 63 relative to its parental *** of nuclear/cytosolic acetylcoenzyme A was also enhanced in the hybrid,which paralleled increases in histone H3 acetylation to selectively target the expression of growth-promoting and metabolic *** acetylation of cellular proteins,including TARGET OF RAPAMYCIN complex 1,ribosomal proteins,and energy metabolism enzymes,was also augmented and/or remodeled to modulate their *** data indicate that an enhanced network of energy-producing metabolic activity and growth-promoting histone acetylation/gene expression in the hybrid could contribute to its superior growth rate and may constitute a model to explain heterosis.

关键词： heterosis TORC1 r-protein lysine acetylation energy metabolism hybrid rice

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Effects of microwave radiation on brain energy metabolism and related mechanisms

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Journal of Medical Colleges of PLA(China) 2014年第4期29卷 235-243页

作者： Yan-Hui Hao Li Zhao Rui-Yun Peng Beijing Institute of Radiation Medicine

With the rapid development of electronic technologies, anxiety regarding the potential health hazards induced by microwave radiation(MW) has been growing in recent years. The brain is one of the most sensitive target organs for microwave radiation, where mitochondrial injury occurs earlier and more severely than in other organs. energy metabolism disorders do play an important role during the process of microwave radiation-induced brain damage. In this paper, we will review the biological effects of microwave radiation, the features of brain energy supply and consumption and the effects of microwave radiation on mitochondrial energy metabolism and potential related mechanisms.

关键词： Microwave radiation Brain energy metabolism Mitochondria Mechanisms

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Solanine Interferes with AKT/p-AKT and PI3K/p-PI3K Pathway to Inhibit HIF and Destroy Cell energy metabolism

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Journal of Biosciences and Medicines 2021年第10期9卷 89-95页

作者： Yidong Wang Peng Wang Wenbing Zhao Department of Urology Surgery Shanxi Hospital of Integrated Traditional and Western Medicine Taiyuan China

The purpose of this study was to explore the mechanism of Solanine disrupting energy metabolism in human renal cancer ACHN cells and to clarify its target. The specific method was to culture human renal cancer ACHN cell lines, and to intervene with Solanine of high, medium and low concentrations. The content of ATP in cells was measured by ELISA method. The expression of HIF-1α protein and the expression of PI3K, AKT, p-PI3K, p-AKT in PI3K/AKT pathway were detected by Western blotting. The results showed that compared with the control group, the relative expression of p-PI3K and p-AKT showed a downward trend with the increase of Solanine concentration (P 0.05). In addition, the relative expression of HIF-1α also showed a downward trend (P energy metabolism of renal cancer cells, the main mechanism of which is the down-regulation of HI-1αf downstream of the PI3K/Akt pathway by inhibiting the phosphorylation process of PI3K/p-PI3K and Akt/p-Akt.

关键词： Renal Carcinoma Solanine energy metabolism PI3K/Akt Signaling Pathway HIF-1 Alpha

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The Effects of Nutritional Interventions on energy metabolism

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Journal of Nutritional Oncology 2022年第3期7卷 120-127页

作者： Qian Tang Hai Ning Yu Sheng Rong Shen College of Pharmaceutical Science Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Department of Nutrition Zhejiang UniversityHangzhou 310058ZhejiangChina

energy metabolism is vital to the body's metabolic processes.A key player in the production of ATP,mitochondria directly affect energy *** dysfunction is the cause of many *** reports have suggested that nutritional interventions can play a protective role against the development of mitochondrial dysfunction or in ameliorating existing dysfunction,such as by improving energy *** review focuses on the impact of different nutritional interventions on energy metabolism.

关键词： energy metabolism Mitochondrial disorders Nutritional interventions Oxidative stress Mitochondrial dysfunction

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