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Clinical results of non-Descemet stripping endothelial keratoplasty

International Journal of Ophthalmology(English edition) 2017年第2期10卷 223-227页

作者： Tao Zhang Shao-Wei Li Tie-Hong Chen Jing-Liang He Yan-Wei Kang Fang-Qi Lyu Jian-Hua Ning Chang Liu Department of Ophthalmology Aier School of OphthalmologyCentral South University Department of Ophthalmology Beijing Aier-Intech Eye Hospital Department of Ophthalmology Shenyang Aier Eye Hospital

AIM： To investigate the impact of non-Descemet stripping endothelial keratoplasty（non-DSEK） on graft rejection rate,and its overall procedural effectiveness in ***： Non-DSEK was performed on 65 eyes of 64 patients,and the procedural outcomes,including rejection episodes,failure and dislocation of the grafts,best corrected visual acuity（BCVA）,endothelial cell density（ECD）,and other complications,were analyzed ***： Of the 65 eyes,63 recovered from bullous keratopathy with a clear *** mean follow-up time was 26.4mo（range,6-84mo）.The mean BCVA improved from 1.70 log MAR preoperatively to 0.54 log MAR at 3mo,0.46 logM AR at 6mo,and 0.37 logM AR at 1y after *** postoperative donor ECD of the 25 patients who successfully underwent specular microscopic examination was 1918±534 cells/mm^2（range,637 to 3056 cells/mm^2）,and the mean endothelial cell loss was 41.9% at 24 mo *** eye developed secondary glaucoma and required regrafting via penetrating keratoplasty（PKP）.Another eye had postoperative graft failure due to rejection at 26 *** graft dislocation occurred in eight *** of the eight dislocated grafts were reattached using air ***： Immunological graft rejection of the donor graft rarely occurs in ***,non-DSEK is a safe,concise,and effective alternative to restore corneal decompensation when the Descemet membrane is disease-free.

关键词： endothelial keratoplasty non-Descemet stripping endothelial keratoplasty endothelial dysfunction Descemet membrane

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Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital

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Eye and Vision 2014年第1期1卷 51-54页

作者： Alvin L Young Rachel PW Kwok Vishal Jhanji Lulu L Cheng Srinivas K Rao Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Darshan Eye Clinic ChennaiIndia.

Background:endothelial keratoplasty(EK)is used increasingly for the management of cases with endothelial ***-term outcomes of the surgery are not widely reported in the *** report our experience of EK in Chinese eyes at a University teaching ***:Retrospective analysis was performed for all cases of EK performed between 2005 and *** analyzed included indication for surgery,associated surgical procedures,complications,best-corrected visual acuity(BCVA)and overall graft ***:Overall,22 eyes of 21 patients underwent EK(13 males,8 females,mean age 71.8±11.3 years).Pseudophakic bullous keratopathy was the leading indication for surgery(n=12)followed by Fuchs’endothelial dystrophy(n=4),or both(n=3).Other indications for surgery included failed penetrating keratoplasty(n=2)and endothelial decompensation due to multiple surgeries(n=1).Triple procedure was performed in 5(22.7%)*** were noted in the form of postoperative interface hemorrhage(n=2,9%)and graft dislocation(n=1,4.5%).The mean postoperative endothelial cell density was 1069±585.8 cells/*** mean postoperative pachymetry was 675.8±108.5μ*** mean preoperative and postoperative intraocular pressure was 11.3±3.2 and 13.9±4.5 mmHg *** the last follow-up(mean,47.4±13.7 months),BCVA was≥20/70 in 9(40.9%)*** of poor BCVA included primary graft failure(n=4),graft decompensation(n=4),advanced glaucoma(n=2)and irreversible graft rejection(n=2).Graft remained clear in 12(54.5%)cases at the last *** graft survival was 19.7±17.7 months(median 17.5 months).Conclusions:Nearly half of the EK grafts in our study survived over a period of five *** failure,glaucoma and graft rejection were the main causes of poor graft survival.

关键词： endothelial keratoplasty keratoplasty Long-term outcomes

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A 5-year analysis of endothelial vs penetrating keratoplasty graft survival in Chinese patients

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1374-1377页

作者： Anita Lai Wah Li Rachel Pui Wai Kwok Ka Wai Kam Alvin Lerrmann Young Department of Ophthalmology and Visual Sciences Prince of Wales Hospital&Alice Ho Miu Ling Nethersole HospitalNew Territories East ClusterHospital Authoritythe Chinese University of Hong KongHong Kong SARChina

AIM:To determine if there is any difference in longterm graft survival between Descemet’s stripping endothelial keratoplasty(DSEK)and penetrating keratoplasty(PK).METHODS:A retrospective 5-year cases analysis of bullous keratopathy secondary to Fuchs’endothelial dystrophy or pseudophakic bullous keratopathy,receiving either DSEK or PK.A total of 42 DSEK cases and 25 PK cases were included in the ***:In the 5-year analysis,graft survival rates were very similar in the two groups(DSEK 77.1%vs PK76.0%.P=0.918.95%CI:-6.3 to 33.4).Sub-analyses at 1y(DSEK 81%vs PK 95%.P=0.085.95%CI:-29 to 3.6)and 2y(DSEK 81%vs PK 88%.P=0.381.95%CI:-25.9 to 11.8)show a trend towards lower survival rates of DSEK vs PK,but the results were not statistically ***:Longterm 5-year graft survival is similar between the DSEK and PK methods of corneal transplant in Chinese patients with bullous keratopathy.

关键词： cornea endothelial keratoplasty corneal graft

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Indications for and techniques of keratoplasty at Vietnam National Institute of Ophthalmology

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 379-383页

作者： Pham Ngoc Dong Truong Nhu Han Anthony J.Aldave Hoang Thi Minh Chau Vietnam National Institute of Ophthalmology HanoiVietnam Stein Eye Institute the University of California Los Angeles CA 90095-7003 USA

AIM： To report the indications for and techniques of corneal transplantation at Vietnam National Institute of Ophthalmology （VNIO） over a period of 12y （2002-2013）, METHODS： Records of patients who had undergone corneal transplantation at VNIO from January 1, 2002 to January 1, 2014 were reviewed to determine the indication for and type of corneal transplant performed. Patient age, gender, indication for corneal transplantation and surgical technique were recorded and analyzed. RESULTS： Corneal transplantation were underwent in 1390 eyes of 1278 patients with a mean age of 44.9±18.1y during the period under review. The most common indication was infectious corneal ulcer （n=670; 48.2%）, followed by corneal scar （n=333, 24.0% ）, corneal dystrophy （n=138, 9.9%） and failed graft （n=112, 8.1%）. Nearly all procedures performed were penetrating keratoplasty （n=1300, 93.5% ）, with a few lamellar keratoplasty procedures performed： lamellar keratoplasty （n=52, 3.7%）, Descemet＇s stripping automated endothelial keratoplasty （n =27, 1.9% ） and deep anterior lamellar keratoplasty （n =11, 0.8%）.CONCLUSION： While the most common indication for keratoplasty was infectious keratitis, nearly all indications for corneal transplantation were managed with penetrating keratoplasty, However, lamellar keratoplasty techniques, including deep anterior lamellar keratoplasty and Descemet＇s stripping automated endothelial keratoplasty, are being performed with increasing frequency for isolated stromal and endothelial disorders, respectively,

关键词： penetratingkeratoplasty, lamellarkeratoplasty endothelial keratoplasty indication for keratoplasty technique of keratoplasty

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