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Aluminum phosphate gel reduces early rebleeding in cirrhotic patients with gastric variceal bleeding treated with histoacryl injection therapy

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World Journal of Gastrointestinal Endoscopy 2023年第3期15卷 153-162页

作者： Hao-Tian Zeng Zhu-Liang Zhang Xi-Min Lin Min-Si Peng Li-Sheng Wang Zheng-Lei Xu Department of Gastroenterology The Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND Esophageal-gastro varices bleeding(EGVB)is the most widely known cause of mortality in individuals with cirrhosis,with an occurrence rate of 5%to 15%.Among them,gastric varices bleeding(GVB)is less frequent than esophageal varices bleeding(EVB),but the former is a more critical illness and has a higher mortality *** present,endoscopic variceal histoacryl injection therapy(EVHT)is safe and effective,and it has been recommended by relevant guidelines as the primary method for the treatment of ***,gastric varices after endoscopic treatment still have a high rate of early rebleeding,which is mainly related to complications of its treatment,such as bleeding from drained ulcers,rebleeding of varices ***,preventing early postoperative rebleeding is very important to improve the quality of patient survival and *** To assess the efficacy of aluminium phosphate gel(APG)combined with proton pump inhibitor(PPI)in preventing early rebleeding after EVHT in individuals with *** Medical history of 196 individuals with GVB was obtained who were diagnosed using endoscopy and treated with EVHT in Shenzhen People's Hospital from January 2016 to December *** on the selection criteria,101 patients were sorted into the PPI alone treatment group,and 95 patients were sorted into the PPI combined with the APG treatment *** incidences of early rebleeding and corresponding complications within 6 wk after treatment were compared between both *** methods were performed by two-sample t-test,Wilcoxon rank sum test andχ2 *** No major variations were noted between the individuals of the two groups in terms of age,gender,Model for End-Stage Liver Disease score,coagulation function,serum albumin,hemoglobin,type of gastric varices,the dose of tissue glue injection and EV that needed to be treated *** early rebleeding rate in PPI+APG group was 3.16%(3/95),which was much lower than that in the PPI group(

关键词： Gastric varices bleeding endoscopic variceal histoacryl injection therapy Proton pump inhibitor Aluminium phosphate gel Early rebleeding

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