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Advances in endoscopic diagnosis and management of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4045-4051页

作者： Shi-Wei Li Xiang Liu Si-Yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal endoscopic Techniques Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Colorectal cancer(CRC)is a leading global health concern,and early identification and precise prognosis play a vital role in enhancing patient *** is a minimally invasive imaging technique that is crucial for the screening,diagnosis,and treatment of *** editorial discusses the importance of advances in endoscopic techniques,the integration of artificial intelligence,and the potential of novel technologies in enhancing the diagnosis and management of CRC.

关键词： Colorectal cancer endoscopic diagnosis endoscopic management Artificial intelligence endoscopic devices

Colorectal cancer in geriatric patients: endoscopic diagnosis and surgical treatment

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World Journal of Gastroenterology 2005年第3期11卷 315-318页

作者： Andreas Kirchgatterer Pius Steiner Dietmar Hubner Eva Fritz Gerhard Aschl Josef Preisinger Maximilian Hinterreiter Bernhard Stadler Peter Knoflach First Department of Medicine/Gastroenterology Second Department of Surgery

AIM: To investigate the prevalence of colorectal cancer in geriatrie patients undergoing endoscopy and to analyze their outcome. METHODS: All consecutive patients older than 80 years who underwent lower gastrointestinal endoscopy between January 1995 and December 2002 at our institution were included. patients with endoscopic diagnosis of colorectal cancer were evaluated with respect to indication, localization and stage of cancer, therapeutic consequences, and survival. RESULTS: Colorectal cancer was diagnosed in 88 patients (6% of all endoscopies, 55 women and 33 men, mean age 85.2 years). Frequent indications were lower gastrointestinal bleeding (25%), anemia (24%) or sonographic suspicion of tumor (10%). Localization of cancer was predominantly the sigmoid colon (27%), the rectum (26%), and the ascending colon (20%). Stage Dukes A was rare (1%), but Dukes D was diagnosed in 22% of cases. Curative surgery was performed in 54 patients (61.4%), in the remaining 34 patients (38.6%) surgical treatment was not feasible due to malnutrition and asthenia or cardiopulmonary comorbidity (15 patients), distant metastases (11 patients) or refusal of operation (8 patients). patients undergoing surgery had a very low in-hospital mortality rate (2%). Operated patients had a one-year and three-year survival rate of 88% and 49%, and the survival rates for non-operated patients amounted to 46% and 13% respectively. CONCLUSION: Nearly two-thirds of 88 geriatrie patiente with endoscopic diagnosis of colorectal cancer underwent successful surgery at a very low perioperative mortality rate, resulting in significantly higher survival rates. Hence, the clinical relevance of lower gastrointestinal endoscopy and oncologic surgery in geriatrie patients is demonstrated.

关键词： Colorectal cancer endoscopic diagnosis Surgical treatment

The different effects between common gastroscopy and anesthesia gastroscopy on endoscopic diagnosis

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The different effects between common gastroscopy and anesthe...

Evolving role of artificial intelligence in gastrointestinal endoscopy

第三十一届全国中西医结合消化系统疾病学术会议

作者： Haifeng Jin Bin Lyu Liang Huang Lina Meng The First Affiliated Hospital of Zhejiang Chinese Medicine University

Background/Aims:More and more people intend to receive painless gastroscopy because of its better comfort than common gastroscopy,but the effects of those two different gastroscopy on endoscopic diagnosis are less *** aim of this study was to determine effects of common gastroscopy and painless gastroscopy on endoscopic *** Patients were divided into two group (A:common gastroscopy,n=956;B:painless gastroscopy,n=6948) according their wishes to receive gastroscopy from Jan.1st,2015 to Des.30th,2015 in The First Affiliated Hospital of Zhejiang Chinese Medicine University,performed by the same endoscopic *** endoscopic diagnosis data was collected;the detection rates of reflux esophagitis、chronic non-atrophicgastritis、chronic atrophic gastritis、gastric ulcer、duodenal ulcer、gastric benign polyps and early gastric cancer were taken as indexes to assess the differences effects between the two kinds of endoscopy on endoscopic *** 1) the characterize of patients in two group was not significant (Men and women proportion was 0.63:1,average age was 47.34,in B group;Men and women proportion was 0.78:1,average age was 51.69,in A group;P>0.05);2) The differences of detection rates of chronic non-atrophic gastritis and chronic atrophic gastritis were not significant (57.85%,33.05%in B group,Vs.58.30%,36.14%in A group;P>0.05,P>0.05,respectively);3) the detection rates of gastric benign polyps and early gastric cancer in B group were higher than those in A group (22.38%and 0.52%in B group,Vs.3.51%,0.2%in A group;P<0.001,P<0.05,respectively);4) the detection rates of reflux esophagitis、gastric ulcer and duodenal ulcer in B group were lower than in A group (13.81%,8.58%and 22.07%in B group,Vs.33.38%,25.45%,33.43%in A group;P<0.001,P<0.001,P<0.001,respectively).Conclusions:Painless gastroscopy may increase the detection rates of gastric benign polyps and early gastric cancer while common gastroscopy shows some advantage of detection rate in

关键词： gastroscopy endoscopic diagnosis

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World Journal of Gastroenterology 2020年第46期26卷 7287-7298页

作者： Gulshan Parasher Morgan Wong Manmeet Rawat Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of New Mexico School of MedicineAlbuquerqueNM 87131United States

Artificial intelligence(AI)is a combination of different technologies that enable machines to sense,comprehend,and learn with human-like levels of *** technology will eventually enhance human capability,provide machines genuine autonomy,and reduce errors,and increase productivity and *** seems promising,and the field is full of invention,novel applications;however,the limitation of machine learning suggests a cautious optimism as the right *** is also becoming incorporated into medicine to improve patient care by speeding up processes and achieving greater accuracy for optimal patient *** using deep learning technology has been used to identify,differentiate catalog images in several medical fields including gastrointestinal *** gastrointestinal endoscopy field involves endoscopic diagnoses and prognostication of various digestive diseases using image analysis with the help of various gastrointestinal endoscopic device ***-based endoscopic systems can reliably detect and provide crucial information on gastrointestinal pathology based on their training and *** systems can make gastroenterology practice easier,faster,more reliable,and reduce inter-observer variability in the coming ***,the thought that these systems will replace human decision making replace gastrointestinal endoscopists does not seem plausible in the near *** this review,we discuss AI and associated various technological terminologies,evolving role in gastrointestinal endoscopy,and future possibilities.

关键词： Artificial intelligence Gastrointestinal endoscopy Machine learning endoscopic diagnosis Gastric cancer Gastrointestinal diseases

Artificial intelligence technique in detection of early esophageal cancer

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World Journal of Gastroenterology 2020年第39期26卷 5959-5969页

作者： Lu-Ming Huang Wen-Juan Yang Zhi-Yin Huang Cheng-Wei Tang Jing Li Department of Gastroenterology West China Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Due to the rapid progression and poor prognosis of esophageal cancer(EC),the early detection and diagnosis of early EC are of great value for the prognosis improvement of ***,the endoscopic detection of early EC,especially Barrett's dysplasia or squamous epithelial dysplasia,is ***,the requirement for more efficient methods of detection and characterization of early EC has led to intensive research in the field of artificial intelligence(AI).Deep learning(DL)has brought about breakthroughs in processing images,videos,and other aspects,whereas convolutional neural networks(CNNs)have shone lights on detection of endoscopic images and *** studies on CNNs in endoscopic analysis of early EC demonstrate excellent performance including sensitivity and specificity and progress gradually from in vitro image analysis for classification to real-time detection of early esophageal *** AI technique comes to the pathological diagnosis,borderline lesions that are difficult to determine may become easier than *** gene diagnosis,due to the lack of tissue specificity of gene diagnostic markers,they can only be used as supplementary measures at *** predicting the risk of cancer,there is still a lack of prospective clinical research to confirm the accuracy of the risk stratification model.

关键词： Artificial intelligence Early esophageal cancer Barrett's esophagus Esophageal squamous cell carcinoma endoscopic diagnosis Pathological diagnosis

Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy

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World Journal of Gastroenterology 2016年第41期22卷 9196-9204页

作者： Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri Department of Endoscopy The Jikei University School of Medicine Department of Endoscopy The Jikei University Katsushika Medical Center Division of Clinical Epidemiology The Jikei University School of Medicine Department of Pathology The Jikei University School of Medicine Department of Innovative Interventional Endoscopy Research The Jikei University School of Medicine

AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops(IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes(VS)" of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's *** Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria,

关键词： Simplified criteria Narrow Band Imaging Magnifying endoscopy Esophageal cancer Squamous cell carcinoma endoscopic diagnosis Classification Superficial squamous cell carcinoma Stepwise logistic regression analysis

Cystic pancreatic lesions,the endless dilemma

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World Journal of Gastroenterology 2021年第21期27卷 2664-2680页

作者： Hussein Hassan Okasha Abeer Awad Ahmed El-meligui Reem Ezzat Ashraf Aboubakr Sameh AbouElenin Ramy El-Husseiny Ahmed Alzamzamy Department of Internal Medicine and Gastroenterology Hepatology UnitKasr Al-Aini HospitalsCairo UniversityCairo 11562Egypt Department of Internal Medicine and Gastroenterology Hepatology UnitAssuit UniversityAssuit 71515Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11441Egypt Department of Gastroenterology and Hepatology Military Medical AcademyCairo 11441Egypt Department of Hepatology and Tropical Medicine National Hepatology and Tropical Medicine Research Institute(NHTMRI)Cairo 11441Egypt

Cystic pancreatic lesions involve a wide variety of pathological entities that include neoplastic and non-neoplastic *** proper diagnosis,differentiation,and staging of these cystic lesions are considered a crucial issue in planning further *** are great challenges for their diagnostic *** our time,new emerging methods for this diagnosis have been *** ultrasonography-guided fine-needle aspiration cytology with chemical and molecular analysis of cyst fluid and EUS-guided fine needlebased confocal laser endomicroscopy,through the needle microforceps biopsy,and single-operator cho-langioscopy/pancreatoscopy are promising methods that have been used in the diagnosis of cystic pancreatic *** we discuss the diagnosis of cystic pancreatic lesions and the benefits of various diagnostic models.

关键词： Pancreatic cystic lesion endoscopic diagnosis endoscopic ultrasonography Cyst fluid markers endoscopic ultrasonography-guided fine needle-based confocal laser endomicroscopy Through the needle microforceps biopsy Single operator cholangioscopy/pancreatoscopy

Diagnostic utility of narrow-band imaging endoscopy for pharyngeal superfi cial carcinoma

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World Journal of Gastroenterology 2011年第45期17卷 4999-5006页

作者： Noboru Yoshimura Kenichi Goda Hisao Tajiri Yukinaga Yoshida Takakuni Kato Yoichi Seino Masahiro Ikegami Mitsuyoshi Urashima Department of Endoscopy The Jikei University School of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine Department of Otorhinolaryngology The Jikei University School of Medicine Department of Pathology The Jikei University School of Medicine Clinical Research and Development The Jikei University School of Medicine

AIM: To investigate the endoscopic features of pharyngeal superfi cial carcinoma and evaluate the utility of narrow-band imaging (NBI) for this disease. METHODS: In the present prospective study, 335 patients underwent conventional white light (CWL) en-doscopy and non-magnifi ed/magnifi ed NBI endoscopy, followed by an endoscopic biopsy, for 445 superfi cial lesions in the oropharynx and hypopharynx. The macroscopic appearance of superfi cial lesions was categorized as either elevated (endoscopic fi ndings made the histological diagnoses. By comparing endoscopic fi ndings with histology, we determined the endoscopic features of SC and evaluated the diagnostic utility of NBI. RESULTS: The 445 lesions were divided histologically into two groups: a non-SC group, including non-neoplasia and low-grade dysplasia cases, and an SC group. Of the 445 lesions examined, 333 were classified as non-SC and 112 were classif ied as SC. There were no significant differences in age, gender, or the location of the lesions between the patients in the two groups. The mean diameter of the SC lesions was signif icantly greater than that of non-SC lesions (11.0 ± 7.6 mm vs 4.6 ± 3.6 mm, respectively, P < 0.001). Comparisons of CWL endoscopy fi ndings for SC and non-SC lesions by univariate analysis revealed that the incidence of redness (72% vs 41%, respectively, P < 0.001) and a flat or depressed type of lesion (58% vs 44%, respectively, P = 0.013) was signif

关键词： Narrow-band imaging Magnified endoscopy endoscopic diagnosis Pharynx Pharyngeal cancer Superfi cial carcinoma Squamous cell carcinoma Dysplasia

Goblet cell carcinoid of the appendix:Six case reports

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World Journal of Clinical Cases 2024年第22期12卷 5217-5224页

作者： Toshiaki Toshima Ryo Inada Shinya Sakamoto Eri Takeda Takahiro Yoshioka Kento Kumon Naoki Mimura Nobuo Takata Motoyasu Tabuchi Kazuyuki Oishi Takuji Sato Kenta Sui Takehiro Okabayashi Kazuhide Ozaki Toshio Nakamura Yuichi Shibuya Manabu Matsumoto Jun Iwata Department of Gastroenterological Surgery Kochi Health Sciences CenterKochi 781-8555Japan Department of Diagnostic Pathology Kochi Health Sciences CenterKochi 781-8555Japan

BACKGROUND Goblet cell carcinoid(GCC)of the appendix is a rare tumor characterized by neuroendocrine and adenocarcinoma *** preoperative diagnosis is very difficult,with most patients complaining mainly of abdominal *** tomography shows swelling of the appendix,so diagnosis is usually made incidentally after appendectomy based on a preoperative diagnosis of *** if a patient undergoes preoperative colonoscopy,accurate endoscopic diagnosis is very difficult because GCC shows a submucosal growth pattern with invasion of the appendiceal *** SUMMARY Between 2017 and 2022,6 patients with GCC were treated in our *** presenting complaint for 5 of these 6 patients was abdominal *** 5 patients underwent appendectomy,including 4 for a preoperative diagnosis of appendicitis and the other for diagnosis and treatment of an appendiceal *** sixth patient presented with vomiting and underwent ileocecal resection for GCC diagnosed from preoperative *** 2 patients with GCC underwent colonoscopy,no neoplastic changes were *** of the six patients showed lymph node metastasis on pathological *** of the last followup(median:15 mo),all cases remained alive without *** As preoperative diagnosis of GCC is difficult,this possibility must be considered during surgical treatments for presumptive appendicitis.

关键词： Goblet cell carcinoid Appendix Preoperative diagnosis endoscopic diagnosis Surgical treatment Case report