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Experimental model standardizing polyvinyl alcohol hydrogel to simulate endoscopic ultrasound and endoscopic ultrasoundelastography

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World Journal of Gastroenterology 2020年第34期26卷 5169-5180页

作者： Elymir S Galvis-García Sergio Sobrino-Cossío Arturo Reding-Bernal Yesica Contreras-Marín Karina Solórzano-Acevedo Patricia González-Zavala Rosa M Quispe-Siccha Unidad de Endoscopía Gastrointestinal Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico Unidad de Endoscopia y Fisiología Digestiva HospitalÁngeles del PedregalMexico 10700Mexico Dirección de Investigación Hospital General de México“Dr.Eduardo Liceaga”Mexico 06720Mexico Unidad Profesional Interdisciplinaria de Biotecnología and Unidad de Investigación y Desarrollo Tecnológico Instituto Politécnico Nacional and Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico Instituto de Investigaciones en Materiales and Unidad de Investigación y Desarrollo Tecnológico Universidad Nacional Autónoma de México and Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico Unidad de Investigación y Desarrollo Tecnológico Hospital General de México"Dr.Eduardo Liceaga"Mexico 06720Mexico

BACKGROUND endoscopic ultrasound(EUS)and endoscopic ultrasound elastography(EUS-E)simulation lessens the learning curve;however,models lack realism,diminishing *** To standardize the mechanical properties of polyvinyl alcohol(PVA)hydrogel for simulating organs and digestive *** PVA hydrogel(Sigma Aldrich,degree of hydrolysis 99%)for simulating EUS/EUS-E lesions was investigated in Unidad de Investigación y Desarrollo Tecnológico at Hospital General de México“*** Liceaga”,Mexico *** evaluated physical,contrast,elasticity and deformation coefficient characteristics in lesions,applying Kappa’s concordance and satisfaction questionnaire(Likert 4-points).RESULTS PVA hydrogel showed stable mechanical *** depended on molecular weight(MW)and concentration(C).PVA bblocks with the greatest density showed lowest tensile strength(r=-0.8,P=0.01).Lesions were EUSgraphically *** and heterogeneous examples were created from PVA blocks or PVA phantoms,exceeding(MW2=146000-186000,C9=15%and C10=20%)with a density under(MW1=85000-124000,C1=7%and C2=9%).We calculated elasticity and deformation parameters of solid(blue)areas,contrasting with the norm(Kappa=0.8;high degree of satisfaction).CONCLUSION PVA hydrogels were appropriate for simulating organs and digestive lesions using EUS/EUS-E,facilitating practice and reducing *** amplified skills,while reducing the learning curve.

关键词： endoscopic ultrasound simulators in endoscopy Polyvinyl alcohol endoscopic ultrasound endoscopic ultrasound elastography Strain Elasticity

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Enhanced endoscopic ultrasound imaging for pancreatic lesions: The road to artificial intelligence

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World Journal of Gastroenterology 2022年第29期28卷 3814-3824页

作者： Marco Spadaccini Glenn Koleth James Emmanuel Kareem Khalaf Antonio Facciorusso Fabio Grizzi Cesare Hassan Matteo Colombo Benedetto Mangiavillano Alessandro Fugazza Andrea Anderloni Silvia Carrara Alessandro Repici Digestive Endoscopy Unit Division of GastroenterologyHumanitas Research Hospital and UniversityMilan 20800Italy Department of Gastroenterology and Hepatology Queen ElizabethKota Kinabalu 88200SabahMalaysia Section of Gastroenterology Department of Medical SciencesUniversity of FoggiaFoggia 71122Italy Department of Immunology and Inflammation Humanitas Clinical and Research HospitalRozzano 20089Italy Digestive Endoscopy Unit Division of GasteroenterologyHumanitas Mater DominiCastellanza 21053Italy

Early detection of pancreatic cancer has long eluded clinicians because of its insidious nature and *** metastatic or locally invasive when symptomatic,most patients are deemed *** those who are symptomatic,multi-modal imaging modalities evaluate and confirm pancreatic ductal *** asymptomatic patients,detected pancreatic lesions can be either solid or *** clinical implications of identifying small asymptomatic solid pancreatic lesions(SPLs)ofendoscopic ultrasound(EUS).It carries significant importance when risk stratifying cystic lesions and has substantial diagnostic value when combined with fine needle aspiration/biopsy(FNA/FNB).Adjuncts to EUS imaging include contrast-enhanced harmonic EUS and EUS-elastography,both having improved the specificity of FNA and *** review intends to compile all existing enhancement modalities and explore ongoing research around the most promising of all adjuncts in the field of EUS imaging,artificial intelligence.

关键词： Pancreatic ductal adenocarcinoma Pancreatic cancer endoscopic ultrasound Contrast-enhanced endoscopic ultrasound endoscopic ultrasound contrast agents endoscopic ultrasound elastography Artificial intelligence Fractal analysis Endoscopy Imaging

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