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Autoimmune pancreatitis with atypical imaging findings that mimicked an endocrine tumor

World Journal of Gastroenterology 2010年第23期16卷 2954-2958页

作者： Cindy Neuzillet Céline Lepère Mostafa El Hajjam Laurent Palazzo Monique Fabre Hajer Turki Pascal Hammel Philippe Rougier Emmanuel Mitry Department of Digestive Surgery and Gastroenterology and Digestive Oncology Ambroise Paré Hospital9avenue Charles de Gaulle Radiology Unit Ambroise Paré Hospital9avenue Charles de Gaulle Medical off ice of Gastroenterology 30rue d'Astorg Pathology Unit Bicêtre Hospital78rue du Général Leclerc Department of Digestive Surgery and Gastroenterology PMADBeaujon Hospital100 boulevard du Général Leclerc EA 4340 Faculty of Medicine of West Paris University of Versailles Saint-Quentin9 boulevard d'Alembert

Autoimmune pancreatitis(AIP) is a rare cause of recurrent acute pancreatitis or chronic pancreatitis in middleaged patients,and is characterised by a marked infiltration of lymphocytes and plasma cells in pancreatic *** of focal forms can be diff icult as AIP may mimic pancreatic *** cases of AIP are *** report the case of a 15-yearold girl who had a focal AIP and associated cholangitis,with a very unusual vascularized mass that mimicked a pancreatic endocrine *** diagnosis was obtained by a pancreatic biopsy,thus avoiding surgical resection,and all the clinical,biological and radiological abnormalities resolved after steroid therapy with 6 mo of follow-up.

关键词： Pancreas Autoimmune pancreatitis Adolescent endocrine tumor Biopsy

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Microwave ablation combined with hepatectomy for treatment of neuroendocrine tumor liver metastases

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World Journal of Clinical Cases 2021年第19期9卷 5064-5072页

作者： Jin-Zhu Zhang Shu Li Wei-Hua Zhu Da-Fang Zhang Department of Hepatobiliary Surgery Peking University People's HospitalBeijing 100044China

BACKGROUND Hepatectomy is the first choice for treating neuroendocrine tumor liver ***,most patients with neuroendocrine tumor liver metastases are not suitable for *** combined with hepatectomy can be an alternative to liver *** To explore the clinical effect of microwave ablation combined with hepatectomy for the treatment of neuroendocrine tumor liver *** In this study,the data of patients who underwent microwave ablation combined with hepatectomy for the treatment of neuroendocrine tumor liver metastases from June 2015 to January 2018 were *** the operation,the patients did not receive any treatment for liver neuroendocrine *** a multidisciplinary expert group discussion,all patients were deemed unsuitable for liver *** patients were diagnosed with neuroendocrine tumors by *** overall survival time and progression-free survival time were followed by telephone calls and outpatient visits after *** Eleven patients with neuroendocrine tumor liver metastases were treated by microwave ablation combined with hepatectomy between June 2015 and January *** median number of liver metastatic nodules was 4(range,2 to 43).The median number of lesions resected was 1(range,1 to 18),and the median number of lesions ablated was 3(range,1 to 38).The mean operation time was 405.6(±39.4)*** median intraoperative blood loss was 600 mL(range,50 to 3000).Ten patients had a fever after *** median duration of fever was 3 d(range,0 to 21).Elevated bilirubin levels occurred in all patients after *** median bilirubin on the first day after surgery was 28.5(range,10.7 to 98.9)μmol/*** patient developed respiratory failure,renal insufficiency,and pneumonia after the *** patient died postoperatively during *** mean overall survival time after surgery was 34.1(±3.7)mo,and the median progression-free survival time was 8(range,2 to 51)m

关键词： Liver Neoplasm metastasis Microwave Hepatectomy Neoplasm endocrine tumor

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Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features

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World Journal of Gastroenterology 2006年第34期12卷 5440-5446页

作者： Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel Department of Pathology Universityof Kiel Germany Department of Pathology University of Zürich Switzerland Department of Pathology Universityof Kiel Germany Department of Forensic Medicine Universityof Kiel Germany Department of General Visceral andPediatric Surgery University of Düsseldorf Germany Department of General andVisceral Surgery University of Halle-Wittenberg Germany

Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome （ZES）. ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal reflux disease and occasional diarrhea. Genetically, nonhereditary （sporadic） gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 （MEN1） syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors （NETs） includes 18 patients （23.4%） with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients （4.5%） suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished from tumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functio

关键词： endocrine tumor Gastrinoma Multiple endocrine neoplasia type 1 Precursor lesion Zollinger-Ellison syndrome

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