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An overview of the physiopathology and various treatment strategies for polycystic ovary syndrome

生殖与发育医学(英文) 2024年第1期08卷 50-60页

作者： Rajabi Ayda Babaie Soraya Oskouei Behnaz Sadeghzadeh Mehdizadeh Amir Farshbaf-Khalili Azizeh Department of Reproductive Biology Faculty of Advanced Medical Sciences Hematology and Oncology Research Center Student Research Committee 2. Department of Anatomy 3. Faculty of Medicine 4. Yasouj University of Medical Sciences 5. Yasouj 63614 6. Iran Physical Medicine and Rehabilitation Research Center Aging Research Institute 9. Tabriz University of Medical Sciences 10. Tabriz 51368

Polycystic ovary syndrome (PCOS), a common endocrine disorder with metabolic and reproductive consequences, affects a significant percentage of women of reproductive age. Because of its complexity and impact on the quality of life, PCOS requires timely diagnosis and screening for complications. The most common clinical manifestations of PCOS are hirsutism, hyperandrogenism, acne, irregular cycles, amenorrhea, and anovulation. Although PCOS has different clinical manifestations in women, hyperandrogenism, and anovulation are the most common symptoms. A good medical history, examination, blood tests, and ultrasound findings facilitate the diagnosis of PCOS. Novel treatments have also undergone clinical trials to improve the symptoms of PCOS. However, comprehensive review articles investigating the different communities of this disease are limited, and this review aimed to collect data on the different etiologies of PCOS along with the latest diagnostic methods and the most common and up-to-date treatments for this disease.

关键词： Polycystic ovary syndrome endocrine disorder Hyperandrogenism Hyperinsulinemia Anovulation Amenorrhea

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Multiple sclerosis and sexual dysfunction

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Asian Journal of Andrology 2012年第4期14卷 530-535页

作者： Zhen-Ni Guo Si-Yuan He Hong-Liang Zhang Jiang Wu Yi Yang Department of Neurology the First Norman Bethune Hospital of Jilin UniversityJilin UniversityChangchun 130021China

Multiple sclerosis （MS） is a chronic inflammatory demyelinating disorder of the central nervous system characterized by episodic and progressive neurologic dysfunction resulting from inflammatory and autoimmune reactions. The underlying pathogenesis of MS remains largely unclear. However, it is currently accepted as a T cell-mediated autoimmune disease. Among other clinical manifestations, sexual dysfunction （SD） is a painful but still underreported and underdiagnosed symptom of the disorder. SD in MS patients may result from a complex set of conditions and may be associated with multiple anatomic, physiologic, biologic, medical and psychological factors. SD arises primarily from lesions affecting the neural pathways involved in physiologic function. In addition, psychological factors, the side effects of medications and physical symptoms such as fatigue, muscular weakness, menstrual changes, pain and concerns about bladder and bowel incontinence may also be involved. Since MS primarily affects young people, SD secondary to MS may have a great impact on quality of life. Thus, maintaining a healthy sexual life with MS is an important priority. The treatment of SD requires multidisciDlinarv teamwork and coooeration amone specialists,individual patients, partners and the society.

关键词： demyelination endocrine disorder multiple sclerosis sexual dysfunction

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Protective Effects of Mongolian Medicine Borantunggal on Rats with Chronic Renal Insufficiency

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Medicinal Plant 2023年第1期14卷 41-47页

作者： Baoyincang Bailongtang Baotuya Wuyunsiqin Monghjirgal College of Mongolian Medicine Inner Mongolia Medical UniversityHohhot 010059China

[Objectives]To observe the protective effects of Mongolian medicine Borantunggal on rats with chronic renal insufficiency.[Methods]Male Wister rats were gavaged with 50 mg/kg/d adenine for 12 consecutive weeks,and were intervened with positive control drug Niaoduqing and three groups of different doses of Mongolian medicine *** rats general state,such as body posture,hair color,activity status,renal function,thyroid gland,adrenal gland,and gonadal hormone levels,expression levels of inflammatory mediators,α-smooth muscle actin(α-SMA)and nuclear factor-κB(P65)in renal tissue,and histopathological changes of rat kidney were observed before and after treatment.[Results]The recovery of the general state of rats with chronic renal insufficiency in the low dose group after intervention with Mongolian medicine Borantunggal was the most *** with the model group,the level of CRE in the low dose Mongolian medicine group decreased,and the difference was statistically significant(P0.05).The urea level in low,medium and high dose Mongolian medicine groups showed a declining trend,and the effect of low dose Mongolian medicine was *** with the model group,the feed intake of the low dose Mongolian medicine group had an increasing trend,while P and TCHO also had a declining *** with the model group,the levels of LH and COR in the low,medium and high dose Mongolian medicine groups decreased significantly,and the difference was statistically significant(P<0.05).The levels of T,T3 and T4 were significantly increased,the difference was statistically significant(P<0.05),and the effect of low dose Mongolian medicine was *** with the model group,the levels of IL-6,TNF-αand HIF-1 in the low,medium and high dose Mongolian medicine groups were significant

关键词： Chronic renal insufficiency Mongolian medicine Borantunggal Adenine Renal protection endocrine disorder

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