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Assessment of Ozone or Not-Treated Wastewater Ecotoxicity Using Mechanism-Based and Zebrafish Embryo Bioassays

Journal of Environmental Protection 2018年第4期9卷 325-346页

作者： Adriana Wigh Selim Ait-Aissa Nicolas Creusot Hugo Terrisse Marie-Laure Delignette-Muller Alexandre Bergé Emmanuelle Vulliet Bruno Domenjoud Adriana Gonzalez-Ospina Vanessa Brosselin Alain Devaux Sylvie Bony Universite de Lyon INRA USC 1369CNRS UMR 5023 LEHNAVaulx-en-VelinFrance INERIS Unite d’Ecotoxicologie in vitro et in vivo(ECOT)Verneuil-en-HalatteFrance Universite de Lyon CNRSUMR 5558Laboratoire de Biometrie et Biologie EvolutiveVilleurbanneFrance Universite de Lyon Vet Agro Sup Campus Veterinaire de LyonMarcy l’EtoileFrance Universite de Lyon Institut des Sciences AnalytiquesUMR5280 CNRSVilleurbanneFrance SUEZ International-Treatment Infrastructure Wastewater Technical DivisionRueil-MalmaisonFrance

Toxicity of wastewater treatment plant (WWTP) effluents is usually assessed with standardized bioassays, as e.g. the Fish Embryo Toxicity test (FET), but assessment of sub-lethal toxic effects requires to develop more adapted tests. The present work aimed to add the recording of several sub-lethal endpoints in exposed zebrafish embryo-larval stages in order to increase the sensitivity of residual toxicity evaluation of WWTP effluents using a semi-quantitative method (iFET score). This approach was complemented with the genotoxicity assessment on the exposed embryos, a sub-acute hazard particularly relevant to evaluate a potential chronic toxicity risk of low and multi-contaminated environmental matrices. Additionally, endocrine activities of effluents were quantified using human reporter cell lines. This test battery was applied to the assessment of the residual toxicity of five biological treatment effluents, further treated or not using various ozonation treatments intended to improve pharmaceutical compounds removal. Acute toxicity towards zebrafish embryos was very low. However, iFET score approach proposed was able to reveal residual toxicity through the presence of developmental abnormalities in all samples tested. Additionally, a low residual genotoxicity was measured in embryos exposed to two of the WWTP effluents when all excepted one exhibited a residual endocrine activity potential in the ng/L range providing complementary information on the occurrence of endocrine active chemicals and their reduction by different processes. To sum up, such a simplified and ecologically relevant test battery was found sensitive enough to characterize and differentiate various residual effluent’s ecotoxicity at contaminant levels of environmental concern.

关键词： Wastewater Ozonation Genotoxicity endocrine activity Zebrafish Early Life Stage Pharmaceutical Surfactant

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Nutraceutical health benefit and safety utility of Portulaca oleracea: A review focus on neuroendocrine function

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 83-95页

作者： Oyowvi Mega Obukohwo Department of Physiology Adeleke UniversityEdeOsun State PMB 250Nigeria

Background:Portulaca oleracea L.,a traditional medicine with bioactive compounds like flavonoids and omega-3 fatty acids,has gained interest in its neuroendocrine and toxicological ***:The aim of this review is to provide a comprehensive summary of the current knowledge on the neuroendocrine and toxicological activities of Portulaca *** review also highlights the potential mechanisms of action of these ***:A literature search was conducted using various databases such as PubMed,ScienceDirect,and Google *** such as’Portulaca oleracea’,’purslane’,’neuroendocrine activity’,and’toxicological activity’were used to identify relevant *** studies published in English were included in this ***:Portulaca oleracea has been found to improve testicular and cognitive function as well as memory in animal models of Alzheimer’s disease and cerebral ischemia due to its antioxidant,anti-inflammatory properties,anti-anxiety and anti-depressant *** the other hand,Portulaca oleracea has also been reported to possess toxicological *** have shown that high doses of Portulaca oleracea extract can cause liver and kidney damage in animal *** toxic effects of Portulaca oleracea are thought to be due to the presence of oxalates and nitrates in the ***,these toxic effects have not been observed in human studies,where Portulaca oleracea was found to be safe for ***:In conclusion,Portulaca oleracea,a medicinal plant with potential health benefits,has neuroendocrine effects like neuroprotective,anxiolytic,and anti-depressant ***,high doses should be used cautiously due to potential toxicological effects.

关键词： Portulaca oleracea Purslane Neuronal activity endocrine activity Toxicological activity

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