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Influence of TRPV1 and LGR5 on downstream proliferation and invasion-related gene expression in endocardial cancer lesions

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Journal of Hainan Medical University 2018年第2期24卷 95-98页

作者： Mei Liu Hong-Xia Liu Department of Obstetrics and Gynecology Shenmu Hospital in Shaanxi ProvinceShenmuShaanxi Province719300China

Objective:To investigate the influence of TRPV1 and LGR5 on downstream proliferation and invasion-related gene expression in endocardial cancer lesions.Methods:A total of 40 patients with endometrial cancer undergoing surgical treatment in our hospital between June 2013 and June 2017 were selected, TRPV1 and LGR5 gene expression in endometrial cancer tissue and adjacent normal tissue were detected, and their median was referred to divide the patients into high TRPV1 group and low TRPV1 group as well as high LGR5 group and low LGR5 group, 20 cases in each group. The differences in proliferation and invasion gene expression in endometrial cancer tissues with different TRPV1 and LGR5 expression were compared. Results:TRPV1 and LGR5 gene expression in endometrial cancer tissues were significantly higher than those in adjacent tissues. Proliferation genes HMGB1, SRPX2 and Wip-1 mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas ITLN-1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively;invasion genes MTA1, hnRNP H and Snail mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas Dickkopf and DKK1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively.Conclusions:TRPV1 and LGR5 expression abnormally increase in endometrial cancer, which are directly correlated with the expression of downstream proliferation and invasion genes, and can affect the progress of the disease together.

关键词： endocardial cancer TRPV1 LGR5 Proliferation gene Invasion gene

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Tropical Coronary Artery Disease and Arrhythmogenic Potentials—The Changing Pattern towards Endomyocardial Fibrosis—An Analysis

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Case Reports in Clinical Medicine 2018年第6期7卷 397-429页

作者： Ramachandran Muthiah Zion Hospital Azhagiamandapam Kanyakumari District India

Aim: To analyse the increasing burden of coronary artery disease (CAD) in tropical and subtropical belts of the Equator since it remains blurred and carries a grim prognosis. Introduction: Endomyocardial fibrosis [EMF] is a tropical febrile disorder, confined to peculiar and limited geographical areas. Plaque buildup in endocardium and coronary arteries, causing ischemic injury and arrhythmic episodes, is a vanishing mystery in its pathogenesis and emphasizing alternative routes for understanding and treatment of this enigmatic disease. Case Report: 15 cases in various age groups were reported with potential complications of coronary artery disease and arrhythmias, associated with endocardial lesions, the characteristic feature of endomyocardial fibrosis. Conclusion: The narrowing of coronary arteries as a result of thickening of the walls, spasm, inflammation, plaques and its rupture produce ischemic episodes which can occur slowly or suddenly in a devastating pattern with arrhythmogenic potentials. The important steps to prevent and decrease the risk of CAD is to reduce the chance of getting this disorder by epidemiological measures with an advice of blood thinning medications such as small daily dose aspirin, antibiotics in susceptible individuals and revascularization in established myocardial infarction.

关键词： Endomyocardial Fibrosis endocardial Plaques Egg-Cell Calcification (endocardial) Arrhythmias Ischemic Injury Newer Therapeutic Strategies RAS Vaccine

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Experience of a Single Center in the Diagnosis and Classification of Cases of Left Ventricular Noncompaction

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International Journal of Clinical Medicine 2015年第4期6卷 235-248页

作者： Roberta Martinoli Patrizia Saccucci Federica Papetti Alessandro Dofcaci Stefano Piccirilli Ilaria Sansoni Francesca Ianniello Federica Ferrante Maria Banci Department of Biomedicine and Prevention University of Rome “Tor Vergata” Rome Italy Operating Unit of Cardiology Valmontone Hospital Rome Italy Department of Cardiology University of Rome “Tor Vergata” Rome Italy Department of Imaging Diagnostic University Campus Biomedical Rome Italy Operating Unit of Gynecology Valmontone Hospital Rome Italy Operating Unit of Neurology Valmontone Hospital Rome Italy

Objectives: To analyse the clinical profile of consecutive cases of Left Ventricular Non Compaction (LVNC) with particular interest in non-compacted segments valuation. Methods: There were 18,000 patients seen from 2007 to 2010, with a complete evaluation including family history and personal cardiac history, clinical examination and electrocardiography. Diagnosis was based on three published definitions. Results: The diagnosis of LVNC was placed in 1.4% of cases. Clinical and echo-cardiographic data for the 250 cases of LVNC are presented. Trabecular meshwork was observed predominantly at the apex (91.6%), in the lateral and inferior wall (40.4% and 38.0% respectively), and less frequently in the posterior and anterior wall (21.6% and 9.2% respectively). Conclusions: This study suggests that LVNC is a form of cardiomyopathy with higher prevalence and relatively better prognosis than previously reported.

关键词： Cardiomyopathy endocardial Morphogenesis Isolated Left Ventricular Noncompaction Heart Failure Echocardiography

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Accessory Leaflet of Tricuspid Valve Masquerading as Infective Endocarditis Preoperatively and Causing RVOT Obstruction Postoperatively

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World Journal of Cardiovascular Surgery 2015年第2期5卷 7-10页

作者： Nishith Bhargava Saket Agrawal Deepak K. Tempe Deepak K. Satsangi Department of Cardiothoracic and Vascular Surgery (CTVS) GB Pant Hospital (GBPH) New Delhi India GB Pant and GNEC Hospitals New Delhi India

Accessory tricuspid valve tissue is a rare congenital anomaly. We report a case where preoperative echocardiogram was suggestive of infective vegetations over the tricuspid valve but intra-operatively it was found to ... 详细信息

关键词： Accessory Tricuspid Valve endocardial Vegetations Echocardiogram

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Surgical Experience of a Partial Atrioventricular Septal Defect in an Elderly Patient: A Case Report

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World Journal of Cardiovascular Surgery 2013年第2期3卷 31-33页

作者： Yukiharu Sugimura Masaaki Toyama Masanori Katoh Yuji Kato Department of Cardiovascular Surgery Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital Ota Japan Department of Cardiovascular Surgery Kameda Medical Center Chiba Japan

The following paper describes patch closure (bovine pericardial sheet) of an ostium primum atrial septal defect and mitral valve repair (sutured mitral valve cleft + autologous pericardial annuloplasty + Alfieri’s method) in a 50-year-old man. He had been perfectly well until he was brought to the emergency room because of acute heart failure. Chest radiography revealed right-side heart enlargement. Electrocardiography indicated atrial flutter. Echocardiography revealed a large ostium primum atrial septal defect and moderate mitral regurgitation. The pulmonary-to-systemic blood flow ratio was 3.24. First, cardiologists performed catheter ablation of the cavotricuspid isthmus for atrial flutter. We performed patch closure of an ostium primum atrial septal defect and mitral valve repair after the patient’s heart failure was under control. The patient was discharged 13 days postoperatively in a satisfactory condition without any critical complications.

关键词： Partial Atrioventricular Septal Defect Incomplete endocardial Cushion Defect Mitral Regurgitation Elderly Patient Repair

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