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Association between endotoxemia and histological features of nonalcoholic fatty liver disease

World Journal of Gastroenterology 2017年第4期23卷 712-722页

作者： Hiroyuki Kitabatake Naoki Tanaka Naoyuki Fujimori Michiharu Komatsu Ayaka Okubo Kyogo Kakegawa Takefumi Kimura Ayumi Sugiura Tomoo Yamazaki Soichiro Shibata Yuki Ichikawa Satoru Joshita Takeji Umemura Akihiro Matsumoto Masayoshi Koinuma Kenji Sano Toshifumi Aoyama Eiji Tanaka Department of Metabolic Regulation Shinshu University Graduate School of Medicine Department of Internal Medicine Division of GastroenterologyShinshu University School of Medicine Center for Clinical Research Shinshu University Hospital Faculity of Pharmaceutical Sciences Teikyo Heisei University Department of Laboratory Medicine Shinshu University Hospital

AIMTo assess whether surrogate biomarkers of endotoxemia were correlated with the histological features of nonalcoholic fatty liver disease (NAFLD).METHODSOne hundred twenty-six NAFLD patients who had undergone percutaneous liver biopsy were enrolled. Serum lipopolysaccharide (LPS)-binding protein (LBP) and anti-endotoxin core immunoglobulin G (endocab igg) antibody concentrations at the time of liver biopsy were measured using the enzyme-linked immunosorbent assays to examine for relationships between biomarker levels and histological *** LBP concentration was significantly increased in nonalcoholic steatohepatitis (NASH) patients as compared with nonalcoholic fatty liver (NAFL) subjects and was correlated with steatosis (r = 0.38, P endocab igg concentration was comparable between NASH and NAFL patients. No meaningful correlations were detected between endocab igg and histological ***/endocab igg were not correlated with lobular inflammation or fibrosis. More accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH.

关键词： Nonalcoholic steatohepatitis Endotoxemia Lipopolysaccharide-binding protein endocab igg Fibrosis Steatosis

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