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Chinese Chemical Letters 2022年第2期33卷 842-846页

作者： Min Wu Hui Gao Huiying Xu Wei Yi Zhi Zhou Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modiﬁcation and Degradation&Molecular Target and Clinical Pharmacology State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

The Cp;Rh(Ⅲ)-catalyzed asymmetric cascade C-H coupling/intramolecular cyclization of azomethine imines with propargyl carbonates has been developed, affording a variety of chiral tetracyclic indenopyrazolopyrazolone frameworks with good substrate/functional group tolerance and enantioselectivity(up to 97:3 er). Combined experimental studies and DFT calculations revealed the Rh(Ⅲ)-catalyzed stepwise annulation process and clarified the synergy coordination mode of dual directing groups in tuning the selectivity.

关键词： Indenopyrazolopyrazolone Azomethine imine enantioselective synthesis DFT calculations Rhodium(Ⅲ)catalysis

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enantioselective synthesis of Terminal 1,2-Diols from Acyl Chlorides

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Chinese Journal of Chemistry 2012年第11期30卷 2688-2692页

作者：邵攀霖申理滔叶松 Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeoing 100190China

Optically active terminal 1,2-diols were prepared with high enantiopurity via the TMS-quinidine-catalyzed en- antioselective cyclization of acyl chlorides and oxaziridine, followed by reductive ring-opening of the cyc... 详细信息

关键词： 1,2-diols acyl chlorides enantioselective synthesis cinchona alkaloids oxidation

enantioselective synthesis of Chiral 1-Ferrocenyl Alcohol via CBS-Reduction

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Chinese Chemical Letters 2001年第12期12卷 1079-1080页

作者： Chen, WY Lu, J Zhang, YW Shen, ZX Suzhou Univ Dept Chem & Chem Engn Suzhou 215006 Peoples R China

Reduction of prochiral ferrocenyl ketones 2a-e in the presence of 10 mol% of chiral beta -amino alcohols 4a-b provides 1-ferrocenyl alcohols 1a-e in high yields (> 85%) with high optically purity (e.e. up to 96%).

关键词： beta-amino alcohol chiral ferrocene enantioselective synthesis borane

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enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative

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Science China Chemistry 2013年第3期56卷 321-328页

作者： HE Ming PAN ZhaoXi BAI Song LI Pei ZHANG YuPing JIN LinHong HU DeYu YANG Song SONG BaoAn State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering Key Laboratory of Green Pesticides and Agricultural Bioengineering Ministry of Education 3. Guizhou University

The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1,3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline *** adducts were isolated with... 详细信息

关键词： Cinchona alkaloid-based thiourea Mannich reaction β-amino esters enantioselective synthesis

enantioselective synthesis,(Chir)optical Properties,and Postsynthetic Functionalization of Furan-Containing Oxa[5]-,Oxa[6]-,and Dioxa[6]helicenes

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CCS Chemistry 2024年第10期6卷 2439-2451页

作者： Wei Fu Valentina Pelliccioli Raquel Casares-López Juan M.Cuerva Martin Simon Christopher Golz Manuel Alcarazo Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen37077 Göttingen Departamento de Química Orgánica Universidad de GranadaUnidad de Excelencia Química Aplicada a Biomedicina y MedioambienteE-18071 Granada

An expedient synthesis of a series of configurationally stable oxa[5]helicenes,oxa[6]helicenes,and dioxa[6]helicenes has been developed using an intramolecular,highly enantioselective,Au-catalyzed,alkyne hydroarylation *** absolute configuration of the newly prepared structures has been established by crystallography,their inversion barriers have been determined theoretically and experimentally,and their chiroptical properties have been *** of these data with those reported for thia-or carbohelicenes sharing an otherwise identical helical framework enables the establishment of comprehensive correlations between the nature of the embedded(hetero)atom(s)and the magnitude of these *** studies on the postsynthetic functionalization of the oxahelicenes obtained are also ***,siteselective bromination at the 15-position in oxa[5]helicene 5d allows its subsequent manipulation into pyridine-containing aza-oxa[7]helicene 13d;while the two termini of oxa[6]helicene 7d have been intramolecularly cyclised into the pleiadeno[1,12,11-bcde]benzofuran derivative 15d by acidic *** transformations take place without erosion of the enantiopurity.

关键词： Au-catalysis enantioselective synthesis oxa[n]helicenes racemization dynamics postsynthetic functionalization

Inherently Chiral 6,7-Diphenyldibenzo [e,g][1,4]diazocine: enantioselective synthesis and Application as a Ligand Platform

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CCS Chemistry 2023年第4期5卷 982-993页

作者： Yu Luo Xilong Wang Weiming Hu Yan Peng Chaoqin Wang Ting Yu Sidi Cheng Jing Li Yimiao He Chunfang Gan Shuang Luo Qiang Zhu State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530 University of Chinese Academy of Sciences Shijingshan DistrictBeijing 100049 Guangxi Key Laboratory of Natural Polymer Chemistry and Physics College of Chemistry and MaterialsNanning Normal UniversityNanning 530001

Inherently chiral 6,7-diphenyldibenzo[e,g][1,4]diazocine(DDD)has been synthesized enantioselectively for the first time via chiral phosphoric acid(CPA)-catalyzed cyclocondensation of readily available[1,1′-biphenyl]-2,2′-diamine(1a)and benzil(2a)in 82%yield,with 98%ee under mild reaction *** strategy could also be applied to racemic biaryl diamines through kinetic *** unexpectedly high interconversion energy barriers between the enantiomers(ΔG=39.5 kcal/mol)and the chemical stability rendered DDD an ideal platform for developing new chiral ligands and *** inherently chiralDDD-based phosphoramidites,phosphoric acid,mono-and diphosphine ligands were prepared from optically pure diphenol derivative DDDOL as a common *** asymmetric reactions catalyzed by Pd or Rh in the presence of newly developed ligands exhibited comparable or even better enantioselectivities than the corresponding BINOLor SPINOL-derived *** functional theory calculation revealed the origin of the enantioselectivity during the process.

关键词： inherent chirality enantioselective synthesis 6,7-diphenyldibenzo[e,g]diazocine chiral phosphoric acid chiral phosphorus ligand

enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative

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Science China(Physics,Mechanics & Astronomy) 2013年第3期56卷 321-328页

The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isol... 详细信息

The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isolated with high enantiomeric excess （up to 99%）.

关键词： Cinchona alkaloid-based thiourea Mannich reaction p-amino esters enantioselective synthesis

First way of enantioselective synthesis of moxifloxacin intermediate

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Science China Chemistry 2013年第3期56卷 307-311页

作者： LI GuangXun WU Lei FU QingQuan TANG Zhuo ZHANG XiaoMei Natural Products Research Center Chengdu Institution of BiologyChinese Academy of Science Key Laboratory for Asymmetric synthesis and Chiraltechnology of Sichuan Province Chengdu Institute of Organic ChemistryChinese Academy of Sciences

A new method of enantioselective synthesis of(S,S)-2,8-diazobicyclo [4.3.0] nonane was found by using(R)-2-amino-2phenyl-ethanol as chiral induction *** entire synthetic process included 8 steps which were easy to operate with high *** purification method was only simple recrystallization or even used directly in the next step without further *** total yield was 29%.

关键词： enantioselective synthesis moxifloxacin intermediate (S S)-2 8-diazobicyclo [4.3.0] nonane

enantioselective synthesis of Allenes——A Collection of First Generation Technology and Application

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Enantioselective Synthesis of Allenes——A Collection of Fir...

First way of enantioselective synthesis of moxifloxacin intermediate

中国化学会全国第十一届有机合成化学学术研讨会

作者： Shengming Ma Department of Chemistry Fudan University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences

Allenes have been becoming a more and more important class of chemicals showing very attractive reactivities, thus,new methods for the efficient synthesis of allenes are highly *** this lecture,we would like to discuss our first generation technology for the enantioseletcive synthesis of allenes with axial and/or central chiralities from terminal alkynes and aldehydes as well as racemic 2,3-allenylic derivatives.

关键词： Allenes enantioselective synthesis Application

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Science China(Physics,Mechanics & Astronomy) 2013年第3期56卷 307-311页

A new method of enantioselective synthesis of （S,S）-2,8-diazobicyclo [4.3.0] nonane was found by using （R）-2-amino-2- phenyl-ethanol as chiral induction reagent. The entire synthetic process included 8 steps which were easy to operate with high yield. The purification method was only simple recrystallization or even used directly in the next step without further purifica- tion. The total yield was 29%.

关键词： enantioselective synthesis moxifloxacin intermediate (S S)-2 8-diazobicyclo [4.3.0] nonane