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embryonic hypertension following exposure to teratogenic doses of 5-fluoro-2'-Deoxyuridine

Biomedical and Environmental Sciences 1996年第4期9卷 408-417页

作者： VINU D. PATEL ROBERT S. NOLAN NORMAN HU EDWARD B. CLARKA DAVID R. HOOTNICK E. MARK LEVINSOHN AND DAVID S. PACKARD, JR.(Departments of Obstetrics and Gynecology, Anatomy and Cell Biotogy, and Pediatrics, Stale University of New York Health Science C Department of Obstetrics and Gynecology State University of New York Health Science Center Syracuse New York 13210 USA.

The teratogenicity of 5-fluoro-2'-deoxyuridine (FdU) is well established. Previously, we have demonstrated that teratogenic doses of FdU produce hematomas and suggested that those hematomas produced skeletal malformations in chicken embryos. In this study, the cardiovascular effects of teratogenic doses of FdU in chicken embryos were studied. A dose of either 0.026 μg FdU or 0.030 μg FdU was injected into the yolk sacs of fertile chicken eggs containing embryos at Hamburger and Hamilton stages 17-19 of development. The embryos were then returned to the incubator. Aortic systolic and diastolic blood pressure,blood velocity and heart rate were measured at stages 21, 24 or 27 using a servonull system and Doppler ultrasound. In addition, mean arterial blood pressure, blood flow, and stroke volume were calculated from these data. Similar data were also recorded from uninjected and saline injected control embryos. Systolic and mean arterial blood pressures were significantly increased in FdU-treated embryos at stage 27. The other parameters measured or calculated were not significantly different from control embryos. Our study suggests that elevated systolic blood pressure in chicken embryos treated with FdU may lead to hematoma formation and subsequent birth defects

关键词： Deoxyuridine embryonic hypertension following exposure to teratogenic doses of 5-fluoro-2

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